ZSCAN4 Mouse anti-Canine, Human, Clone: OTI3B1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF800448

Catalog No. 50-166-5098

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintece and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.

Specifications

• Antigen: ZSCAN4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ZSCAN4
• Gene Alias: ZNF494
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 106559239, 201516
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3B1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8NAM6
• Gene Symbols: ZSCAN4
• Immunogen: Human recombit protein fragment corresponding to amino acids 164-433 of human ZSCAN4 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human
• Product Type: Antibody
• Isotype: IgG2a