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Invitrogen™ ZSCAN4 Polyclonal Antibody
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Catalog No. PIPA588295
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100 μL
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PIPA588295 100 μL
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Catalog No. PIPA588295 Supplier Invitrogen™ Supplier No. PA588295
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Description

Rabbit Polyclonal Antibody

Positive Samples: SH-SY5Y, Mouse brain; Cellular Location: Chromosome, Nucleus, telomere Immunogen sequence: MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENG.

Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZSCAN4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene ZSCAN4
Gene Accession No. Q8NAM6
Gene Alias BQ559217; C330039H09Rik; RGD1563625; zinc finger and SCAN domain containing 4; zinc finger and SCAN domain containing 4A; zinc finger and SCAN domain containing 4F; zinc finger and SCAN domain containing protein 4F; Zinc finger and SCAN domain-containing protein 4; zinc finger protein 494; ZNF494; ZSCAN4; Zscan4a; Zscan4f
Gene Symbols ZSCAN4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human ZSCAN4 (NP_6898901).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 201516
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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