Invitrogen™ ZWILCH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530663

Catalog No. PIPA530663

Description

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7. Predicted reactivity: Mouse (84%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt].

Specifications

• Antigen: ZWILCH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZWILCH
• Gene Alias: 2310031L18Rik; homolog of Drosophila Zwilch; hZwilch; KNTC1AP; protein zwilch homolog; ZWILCH; zwilch kinetochore protein; Zwilch, kinetochore associated, homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55055
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.67 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9H900
• Gene Symbols: ZWILCH
• Immunogen: Recombinant fragment corresponding to a region within amino acids 363 and 591 of Human ZWILCH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov