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Invitrogen™ Zyxin Polyclonal Antibody
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Catalog No. PIPA5120791
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100 μL
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PIPA5120791 100 μL
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Catalog No. PIPA5120791 Supplier Invitrogen™ Supplier No. PA5120791
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa. The target is usually found in the following locations: Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion. Immunogen sequence: PLTLKEVEEL EQLTQQLMQD MEHPQRQNVA VNELCGRCHQ PLARAQPAVR ALGQLFHIAC FTCHQCAQQL QGQQFYSLEG APYCEGCYTD TLEKCNTCGE PITDRMLRAT GKAYHPHCFT CVVCARPLEG TSFIVDQANR PHCVPDYHKQ YAPRCSVCSE PIMPEPGRDE TVRVVALDKN FHMKCYKCED CGKPLSIEAD DNGCFPLDGH VLCRKCHTAR AQT.

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zyxin
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ZYX
Gene Accession No. Q15942, Q62523
Gene Alias 9530098H06Rik; ESP-2; HED-2; LOW QUALITY PROTEIN: zyxin; R75157; ZYX; Zyxin; zyxin-2
Gene Symbols ZYX
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 350-572 of human Zyxinin (NP_0034521).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114636, 22793, 7791
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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