Invitrogen™ Zyxin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120791

Catalog No. PIPA5120791

Description

Positive test controls include: HeLa. The target is usually found in the following locations: Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion. Immunogen sequence: PLTLKEVEEL EQLTQQLMQD MEHPQRQNVA VNELCGRCHQ PLARAQPAVR ALGQLFHIAC FTCHQCAQQL QGQQFYSLEG APYCEGCYTD TLEKCNTCGE PITDRMLRAT GKAYHPHCFT CVVCARPLEG TSFIVDQANR PHCVPDYHKQ YAPRCSVCSE PIMPEPGRDE TVRVVALDKN FHMKCYKCED CGKPLSIEAD DNGCFPLDGH VLCRKCHTAR AQT.

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Specifications

• Antigen: Zyxin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZYX
• Gene Alias: 9530098H06Rik; ESP-2; HED-2; LOW QUALITY PROTEIN: zyxin; R75157; ZYX; Zyxin; zyxin-2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114636, 22793, 7791
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q15942, Q62523
• Gene Symbols: ZYX
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-572 of human Zyxinin (NP_0034521).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG