Invitrogen™ Zyxin Recombinant Rabbit Monoclonal Antibody (4F9P3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542774

Catalog No. PIMA542774

Description

Positive test controls include: MCF7, Mouse lung. The target is usually found in the following locations: Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion. Immunogen sequence: TQPRGPPASS PAPAPKFSPV TPKFTPVASK FSPGAPGGSG SQPNQKLGHP EALSAGTGSP QPPSFTYAQQ REKPRVQEKQ HPVPPPAQNQ NQVRSPGAPG P.

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Specifications

• Antigen: Zyxin
• Classification: Recombinant Monoclonal
• Concentration: 1.1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15942, Q62523
• Gene Symbols: ZYX
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Zyxin (Q15942).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 4F9P3
• Conjugate: Unconjugated
• Gene: ZYX
• Gene Alias: 9530098H06Rik; ESP-2; HED-2; LOW QUALITY PROTEIN: zyxin; R75157; ZYX; Zyxin; zyxin-2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22793, 7791
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov