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Compounds (solids, liquids, gasses) with well-defined isotopic compositions that act as the ultimate sources of accuracy in mass spectrometric measurements of isotope ratios.
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Vitamin K3-d8 is the deuterium-labeled analogue of menadione used as a stable isotope internal standard and tracer for quantitative analytical methods. Supplied as a high-purity powdered reagent, it is intended for precise quantification in research laboratories and is stable under recommended storage conditions.
High isotopic enrichment for reliable internal standardization.
Purity 99.5% for accurate quantitation.
Suitable for NMR, GC-MS, and LC-MS applications.
Stable as a powder at recommended cold storage temperatures for extended periods.
Available in small-mass packages suitable for trace-level analyses.
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DC-LC3in-D5 is an autophagy inhibitor that attenuates LC3B lipidation by binding with LC3B and disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound demonstrates high selectivity to LC3A/B in the proteome and exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells. It may contribute to anti-HCV or combination research in cancer through inhibiting autophagy.
Acts as an autophagy inhibitor by attenuating LC3B lipidation
Binds with LC3B and disrupts the LC3B-LBP2 interaction
Demonstrates high selectivity to LC3A/B in the proteome
Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
Treatment of HeLa cells with 3-30 μM results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62
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Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labeled Tetrabenazine (HY-B0590). It is the first deuterium approved worldwide for the research of Huntington's disease, or other hyperkinetic movement disorders. This compound is for research use only and not sold to patients. It can be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs.
Used as a tracer
Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Extends half-life in vivo
Improves oral bioavailability
Improves metabolic characteristics
Improves drug safety
Preserves therapeutic properties
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Inorganic Ventures' 10 ppm (µg/mL) 10Boron for ICP-MS is a 100mL certified reference material set in a nitric acid matrix for stability. This boron standard is Traceable to NIST and manufactured in accordance with our stringent Quality Assurance guidelines. See Certificate of Analysis for expiration. ATTENTION: Inorganic Ventures is no longer supplying paper copies of Certificate of Analyses(CoA) and Safety Data Sheets (SDS). Please use this link to download your copies: https://www.inorganicventures.com/coa-sds-search
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DC-LC3in-D5 is a small-molecule autophagy inhibitor that attenuates LC3B lipidation by binding LC3B and disrupting LC3B-LBP2 interactions (reported IC50 ≈ 200 nM). It is supplied as a solid for research use and is used in cellular and biochemical studies of autophagy, antiviral research, and cancer combination studies.
Inhibits LC3B lipidation (IC50 ≈ 200 nM).
High purity (98.62%).
Molecular formula C19H22Cl2N2O3; molecular weight 397.30.
Soluble in DMSO (35.71 mg/mL) with ultrasonic warming; heat to 60°C may be used.
Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).
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