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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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This antibody recognizes endogenous levels of total PCP4 protein. PCP4, also known as calmodulin regulator protein or brain-specific polypeptide, is a calmodulin-binding protein that modulates calmodulin activity and signaling pathways, including calmodulin-dependent kinase. It was originally identified in cerebellar Purkinje cells and is also expressed in the adult rodent hippocampus and cortex, where it may influence neurite outgrowth and neurotransmitter release.
Host species: Rabbit
Species reactivity: Mouse and rat
Applications: Western blotting
Purification method: Protein A and peptide affinity chromatography
Formulation: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol
Storage conditions: Store at –20°C; do not aliquot
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Oxiconazole nitrate (CAS 64211-46-7) is an imidazole derivative with antifungal properties It is designed to inhibit ergosterol synthesis thereby perturbing fungal cell membrane integrity and cellular functions Oxiconazole nitrate exerts its biological activity primarily through inhibition of ergosterol synthesis in fungal cells In in vitro assays oxiconazole nitrate demonstrates fungistatic activity against human pathogenic dermatophytes including Trichophyton rubrum T mentagrophytes and Epidermophyton floccosum with IC50 values typically in the submicromolar range Based on these pharmacological properties oxiconazole nitrate holds research potential in the treatment of fungal infections such as trichophytosis and vaginal candidiasis and has been evaluated in both topical and systemic experimental models
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Chemical. CAS 85618-21-9. Formula C14H28O5S. MW 308.4. Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. The thioether linkage makes it resistant to degradation by beta-glucosidase enzymes. For the stabilization and activation of enzymes. Used for cell lysis experiments.
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Complement factor D-IN-2 is an inhibitor of complement factor D. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. This compound can be used for the research of autoimmune diseases by reducing the excessive activation of complement factor D.
Inhibits complement cascade at an early stage
Reduces excessive activation of complement factor D
Useful for research into autoimmune diseases
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The primary attribute of DDM is its capability to extract hydrophobic proteins while maintaining the solution-phase protein conformation DDM also allows the protein to be reformed following denaturization Most membrane-bound proteins are -helix bundles which are less robust to changes in their cellular environment DDM offers a detergent capable of preserving these proteins This is in contrast to other harsher ionic detergents that destabilize and permanently denature -helical membrane-bound proteins DDM has been used to solubilize the multidrug-transporter protein EmrE as well as the nucleoside-specific porin protein Tsx
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Trehalose-6,6'-dibehenate is an orally active glycolipid that activates Mincle and inflammasome, inducing IL-1β secretion in a caspase activity-dependent manner. This compound also exerts a Myd88-dependent adjuvant activity.
Orally active glycolipid
Activates Mincle and inflammasome
Induces IL-1β secretion in a caspase activity-dependent manner
Exerts Myd88-dependent adjuvant activity
Induces Th-1/Th-17 immune responses
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Sucrose octasulfate sodium is a derivative of sulfated oligosaccharides that acts as a matrix metalloproteinase (MMP) inhibitor. It stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by directly affecting D cells in the gastric mucosa, contributing to its ulcer-healing effect. It can also be used as a pharmaceutical excipient and has shown to improve wound closure in diabetic foot ulcers and venous leg ulcers.