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Cefotaxime-d3 (CAS No 63527-52-6) is a deuterated antibiotic used primarily in pharmacokinetic studies and drug development research As a third-generation cephalosporin it originates from modifications of the beta-lactam antibiotic class targeting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) This disrupts the bacterial cell wall structure leading to cell lysis In vitro activity typically falls within the nanomolar to low micromolar range making it effective in various microbiological research settings Common applications include studies using bacterial cultures cell models and animal studies to evaluate antibacterial efficacy and resistance profiles It is also employed in drug screening processes to assess pharmacokinetic parameters and the metabolism of cephalosporins Experimental concentrations typically depend on the specific research design
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