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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
A nucleoside analog of thymidine that is used to monitor de novo DNA synthesis through click chemistry; can be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition
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Kinetin riboside (CAS 4338-47-0) is a cytokinin analog known to induce apoptosis in cancer cells by modulating intracellular signaling pathways Experimental studies have demonstrated that it inhibits the proliferation of HCT-15 colorectal cancer cells with an IC50 value of 2 5 M indicating pronounced activity at low micromolar concentrations Owing to its defined mechanism of action Kinetin riboside is widely utilized in cancer biology and targeted therapy research to investigate its potential roles in cancer treatment
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Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. This compound is known for its ability to be cleaved by phosphodiesterase I and to bind to bovine liver glutamate dehydrogenase. It functions as a substrate for G-ADP ribosylation of G proteins, a reaction facilitated by bacterial toxins, and is widely used as a fluorescent substrate for the study of ADP ribosylation reactions.
Fluorescent analog of NAD
Cleaved by phosphodiesterase I (from C. adamanteus venom)
Binds to bovine liver glutamate dehydrogenase
Serves as a substrate for G-ADP ribosylation of G proteins
Used as a fluorescent substrate for studying ADP ribosylation reactions
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2'-Deoxyadenosine-5'-triphosphate trisodium, 100 mM solution, PCR Grade, is a nucleotide utilized by cells for DNA synthesis and replication. It serves as a raw material for DNA polymerase to synthesize long DNA strands and is also used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is supplied as an aqueous solution.
Substrate for DNA polymerase
Facilitates DNA synthesis and replication
Suitable for reverse transcription polymerase chain reaction (RT-PCR)
Aqueous solution format
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UDP-GlcNAz disodium is an analogue of UDP-GlcNAc disodium. It is a click chemistry reagent, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions. It also acts as a sugar donor and a substrate for OGTase and O-GlcNAcase, valuable in protein glycosylation research.
Analogue of UDP-GlcNAc disodium
Functions as a click chemistry reagent
Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Acts as a sugar donor
Serves as a substrate for OGTase and O-GlcNAcase
Can glycosylate p62
Glycosidic bond can be cleaved by O-GlcNAcase through catalysis
Incorporated into nuclear proteins in Jurkat cells in *in vitro* studies
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