Nucleosides and Analogues
Medchemexpress LLC 2'-Deoxyguanosine-13C10,15N5 | 872624-05-0 | 282.13 | 1 MG
2'-Deoxyguanosine-13C10,15N5 is a 13C- and 15N-labeled 2'-Deoxyguanosine for research use only. This compound is used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process, with deuteration showing potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Adenosine 5'-monophosphate monohydrate 18422-05-4 25mg
Adenosine 5 -monophosphate monohydrate (CAS 18422-05-4) is a selective small-molecule agonist targeting the adenosine A1 receptor It is designed to activate the receptor thereby modulating intracellular signaling pathways associated with viral replication inhibition Adenosine 5 -monophosphate monohydrate exerts its biological activity primarily through adenosine A1 receptor activation leading to disruption of key steps in herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) genome synthesis and propagation In in vitro studies Adenosine 5 -monophosphate monohydrate demonstrates inhibition of HSV viral replication with an IC50 value ranging from 10 20 M Based on these pharmacological properties Adenosine 5 -monophosphate monohydrate holds research potential in antiviral drug development and mechanistic studies related to adenosine receptor-mediated signaling
Apexbio Technology LLC Adenosine 58-61-7 5g
Adenosine (CAS 58-61-7) is a purine nucleoside consisting of adenine covalently linked to a ribose sugar via a -N9-glycosidic bond Endogenously adenosine modulates cellular signaling through activation of specific G protein-coupled adenosine receptors (A1 A2A A2B and A3) influencing diverse physiological processes such as neurotransmission vasodilation and immune responses In biomedical research adenosine is widely utilized to investigate purinergic signaling pathways cardiac function and the regulation of inflammatory and neuroprotective mechanisms as well as serving as a pharmacological tool in receptor binding and functional assays
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 100 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death in most tested cancer cell lines and decreases tumor growth rate in mouse xenograft models, increasing telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Can be incorporated into de novo-synthesized telomeres by telomerase
- Induces rapid cell death in cancer cell lines
- Decreases tumor growth rate in mouse xenograft models
- Increases telomere dysfunction in tumor cells in vivo
- DNA/RNA synthesis inhibitor
eMolecules 8-Bromo-2'-deoxyadenosine | 14985-44-5 | | 1g
Combi-Blocks | 8-Bromo-2'-deoxyadenosine | 1g | 457917203 | QB-6653 | 95.000 | 14985-44-5 | | 330.142 | C10H12BrN5O3
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Advanced Chemblocks Inc PSI6206; 5G; 98%
Chemical Name: PSI6206 CAS: 863329-66-2 #N/A MDL Number: MFCD19982668 Category: Reference Compound Synonym: PSI6206
Apexbio Technology LLC 2-Deoxycytidine,1g CAS# 951-77-9
2-Deoxycytidine is a cytidine analog [1]. 2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer [1]. 2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC [2]. Other sizes are also available. Please inqury us for quote.
Cambridge Isotope Laboratories 2-Deoxyguanosine H2O (13C10 98% 15N5 96-98%) 25 mg
2-Deoxyguanosine H2O (13C10 98% 15N5 96-98%) 25 mg
TARGETMOL CHEMICALS INC beta-Nicotinamide mononucleoti
Also available in 1 g, 5 mg, 10 mg, 25 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. beta-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). beta-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism. Purity 99.66%
TARGETMOL CHEMICALS INC Ribavirin 500MG
Also available in 1 mL, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Purity 99.82%
Medchemexpress LLC Kinetin triphosphate tetrasodium | 99.9% | 675.2 g/mol | C15H16N5Na4O14P3 | 5 MG
Kinetin triphosphate tetrasodium is an ATP analogue provided as the tetrasodium salt for biochemical research. It modulates kinase activity and has documented use in studies such as Parkinson's disease research. Supplied as a small, concentrated vial suitable for in vitro kinase assays and mechanistic studies.
- High purity (99.92%).
- Supplied as the tetrasodium salt, water-soluble for aqueous assays.
- Provided in small vial sizes (5 mg; 100 mM when dissolved as indicated by supplier).
- Suitable for kinase activity assays and mechanistic studies.
- Datasheet, certificate of analysis, and safety data sheet available for quality and safety information.
TARGETMOL CHEMICALS INC Flavin adenine dinucleotide
Also available in 1 mg, 5 mg, 10 mg, 25 mg, 100 mg and bulk. Please contact Fisher for quotes. Flavin adenine dinucleotide (FAD) is a REDOX cofactor and protein cogroup involved in various metabolic reactions. Purity 100%