Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFR?, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.