Organometallic Compounds
![Trimethyl[[(1E,3E)-2-methylpenta-1,3-dien-1-yl]oxy]silane 95.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-82223-91-4.jpg-250.jpg)
Trimethyl[[(1E,3E)-2-methylpenta-1,3-dien-1-yl]oxy]silane 95.0+%, TCI America™
CAS: 82223-91-4 Molecular Formula: C9H18OSi Molecular Weight (g/mol): 170.327 InChI Key: KCWJPELNBSKTNR-UHFFFAOYSA-N Synonym: (1E,3E)-2-Methyl-1-(trimethylsilyloxy)-1,3-pentadiene PubChem CID: 71407348 IUPAC Name: trimethyl(2-methylpenta-1,3-dienoxy)silane SMILES: CC=CC(=CO[Si](C)(C)C)C
9,9-Dimethyl-9H-9-silafluorene 98.0+%, TCI America™
CAS: 13688-68-1 Molecular Formula: C14H14Si Molecular Weight (g/mol): 210.351 InChI Key: YJQFTKVGILQPMC-UHFFFAOYSA-N Synonym: 5,5-Dimethyl-5H-dibenzo[b,d]silole PubChem CID: 139544 IUPAC Name: 5,5-dimethylbenzo[b][1]benzosilole SMILES: C[Si]1(C2=CC=CC=C2C3=CC=CC=C31)C
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g·mol⁻¹ | C10H21N3O5 | 5 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol linker containing five ethylene glycol units and a terminal primary alcohol, used as a water-soluble reagent for bioconjugation and linker synthesis. It is commonly applied in click chemistry and in the construction of antibody-drug conjugates and PROTACs.
- Azide functionality enables CuAAC and SPAAC click reactions.
- Water-soluble PEG5 spacer improves solubility and flexibility.
- Terminal primary alcohol provides a synthetic handle for derivatization.
- Suitable for ADC linker synthesis and PROTAC construction.
- Supplied as a solid with reported purity >97.0%.
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | ≥97.0% | 263.29 | C10H21N3O5 | 10 G
Azido-PEG5-alcohol is a polyethylene glycol (PEG) linker bearing a terminal azide and a terminal hydroxyl group. It functions as a non-cleavable, five-unit PEG spacer for bioconjugation and click chemistry applications.
- Contains azide (-N3) and terminal alcohol (-OH) functional groups.
- Water-soluble PEG linker suitable for click chemistry and PROTAC/ADC assembly.
- Molecular weight ~263.29 g/mol; formula C10H21N3O5.
- High purity, typically ≥97.0% by manufacturer specification.
- Available in multiple pack sizes, including 10 g.
Medchemexpress LLC Tos-PEG3 | 77544-68-4 | 97.0% | 304.36 | 5 G
Tos-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It can also be used for the synthesis of 3'-aminooxy oligonucleotides solid supports. PROTACs consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, and they exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
- PROTACs degrade target proteins using the ubiquitin-proteasome system.
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g/mol | C10H21N3O5 | 25 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol (PEG) linker containing five ethylene glycol units that is used as a click-chemistry reagent and as a linker in bioconjugation workflows. It participates in copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions and is supplied for research use only.
- Azide functional group for click chemistry
- Five-unit PEG spacer adds hydrophilicity and flexibility
- Suitable for antibody-drug conjugate and PROTAC linker synthesis
- Characterized by NMR and LC-MS, purity >97.0%
- Available in multiple package sizes, including 25 G
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | MFCD20134131 | >97.0% | 263.29 g/mol | C10H21N3O5 | 250 MG
Azido-PEG5-alcohol is a 5-unit polyethylene glycol (PEG) linker bearing an azide and a terminal hydroxyl group, used as a click-chemistry reagent and as a non-cleavable PEG spacer in conjugation and PROTAC synthesis. Purity is ≥97.0%, molecular weight is 263.29 g/mol, and CAS number is 86770-68-5.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
- Compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN.
- Non-cleavable 5-unit PEG spacer to improve solubility and flexibility.
- Available in multiple sizes, including 250 mg.
- High purity suitable for synthetic and conjugation applications.
Medchemexpress LLC 14-azido-3,6,9,12-tetraoxatetradecan-1-ol | 86770-68-5 | 97.0% | 263.29 g/mol | C10H21N3O5 | 1 G
Azido-PEG5-alcohol is a polyethylene glycol (PEG) linker with a terminal azide and a terminal alcohol, used for bioconjugation and linker installation. The azide group enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions, while the PEG5 spacer improves solubility and flexibility for conjugation workflows.
- Terminal azide enables CuAAC and SPAAC click reactions.
- PEG5 spacer increases solubility and reduces steric hindrance.
- Suitable for use as a non-cleavable linker in conjugation chemistry.
- Colorless to light yellow liquid with high purity.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC MK-8245 Trifluoroacetate | 1415559-41-9 | 98.5% | 1 MG
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with anti-diabetic and anti-dyslipidemic efficacy. It demonstrates high potency with an IC50 of 1 nM for human SCD1 and 3 nM for rat and mouse SCD1, and selectively targets Δ-5 and Δ-6 desaturases. Its tetrazole acetic acid moiety facilitates OATPs recognition and liver-targeting.
- Liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)
- Potent inhibition with IC50 of 1 nM for human SCD1
- Shows anti-diabetic and anti-dyslipidemic efficacy
- Tetrazole acetic acid moiety aids OATPs recognition and liver-targeting
- Exhibits significant SCD inhibition in rat hepatocyte assay (IC50 of 68 nM)
- Displays highly selective activity for Δ-5 and Δ-6 desaturases
- Concentrated in the liver in vivo, with low exposure in other tissues
- Improves glucose clearance in eDIO mice