5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine, a well-characterized DNA modification in prokaryotes and eukaryotes. It forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. It can be oxidized to generate 5hmC, 5fC, and 5caC, and is used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.