Aminosaccharides
BIOHIPPO O-GlcNAc Rabbit mAb
U-Blot Pan-O-GlcNAc Rabbit mAb (Monoclonal) is a Rabbit-derived monoclonal antibody that specifically recognizes O-GlcNAc a o-glcnacylation modification at Ser(S)/Thr(T) O-GlcNAc (short for O-linked -N-acetylglucosamine) is a reversible enzymatic post-translational modification found on serine and threonine residues of nucleocytoplasmic proteins The modification is characterized by a -glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc) It is widely involved in the regulation of diverse cellular processes including transcription cell cycle signal transduction and stress response Dysregulation of O-GlcNAcylation has been closely linked to cancer neurodegeneration diabetes and inflammatory diseases Notably elevated O-GlcNAc levels in many cancers have been reported to suppress apoptosis by inhibiting caspase activation Supplied as 100 uL
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 25 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury through the generation of free radicals and depletion of UTP nucleotides. Intoxication with D(+)-Galactosamine hydrochloride also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. The combination of Lipopolysaccharide/D(+)-Galactosamine is a known animal model for inducing acute liver injury, leading to fulminant hepatic failure.
- Causes liver injury through generation of free radicals.
- Leads to depletion of UTP nucleotides.
- Induces renal dysfunction.
- Useful in animal models for acute liver injury.
Medchemexpress LLC O-Linked GlcNAc transferase substrate | 954381-93-2 | 98.25% | 1783.08 | 10 MG
O-Linked GlcNAc transferase substrate is a biologically active peptide that functions as a substrate for O-linked GlcNAc transferase (OGT), a eukaryotic glycosyltransferase that utilizes UDP-GlcNAc as a glycosyl donor.
- Biological active peptide
- Substrate of O-linked GlcNAc transferase (OGT)
- White to off-white solid appearance
- High purity of 98.25%
- Soluble in DMSO and H2O at 100 mg/mL
- Sequence: Lys-Lys-Lys-Tyr-Pro-Gly-Gly-Ser-Thr-Pro-Val-Ser-Ser-Ala-Asn-Met-Met
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 1 G
D(+)-Galactosamine hydrochloride is an established experimental toxin known to primarily cause liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, often leading to renal failure associated with end-stage liver damage. This compound can be used to induce hepatitis models, mimicking viral hepatitis by causing lipid peroxidation and cell membrane deterioration.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Causes caspase-3 activation and DNA fragmentation.
- Used as an animal model for fulminant hepatic failure.
- Induces acute liver failure in mice when co-administered with Lipopolysaccharide.
Medchemexpress LLC D(+)-Galactosamine (hydrochloride) | 1772-03-8 | 99.9% | 215.63 | 200 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Induces caspase-3 activation and DNA fragmentation.
- Used to induce hepatitis models similar to viral hepatitis.
- Induces lipid peroxidation and deterioration of cell membranes.
- Can be used in rat models (Wistar) to study liver damage.
- Can be used in mouse models (C57BL/6J) for acute liver failure induction.
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 500 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary rat hepatocyte cultures.
- Causes caspase-3 activation and DNA fragmentation.
- Induces hepatotoxicity similar to viral hepatitis.
- Suitable for research use only.
Medchemexpress LLC HY-B1125 100mg Medchemexpress, Glucosamine CAS:3416-24-8 Purity:>98%
Medchemexpress, HY-B1125 100mg Glucosamine CAS:3416-24-8 Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical UDP-GalNAcsodIum salt 1mg
A nucleotide sugar; used by glycosyltransferases to glycosylate various substrates
Medchemexpress LLC O-Linked GlcNAc transferase substrate | 954381-93-2 | 98.25% | 1783.08 | 5 MG
O-Linked GlcNAc transferase substrate is a biologically active peptide that acts as a substrate for O-linked GlcNAc transferase (OGT). OGT is a eukaryotic glycosyltransferase that uses UDP-GlcNAc as a glycosyl donor.
- Biologically active peptide
- Peptide substrate of OGT
- Uses UDP-GlcNAc as a glycosyl donor
- White to off-white solid appearance
Medchemexpress LLC D-galactose, 2-amino-2-deoxy-, hydrochloride (1:1) | 1772-03-8 | MFCD00135830 | 100.0% | 215.63 g/mol | C6H14ClNO5 | 10 MG
D(+)-Galactosamine hydrochloride is an analytical reference standard supplied as a high-purity solid hydrochloride salt for research and analytical applications. It is used in toxicology and mechanistic studies and to induce experimental hepatic injury in animal models (e.g., LPS/D-galactosamine models), and is suitable for small-scale analytical assays.
- CAS number 1772-03-8.
- Molecular formula C6H14ClNO5.
- Molecular weight 215.63 g/mol.
- Appearance: solid.
- Form: hydrochloride salt.
- Purity: 99.95% (as listed).
- Available in small sizes including 10 mg for analytical use.
Medchemexpress LLC HY-B0470 10g Medchemexpress, Neomycin (sulfate) CAS:1405-10-3 Purity:98%
Medchemexpress,HY-B0470 10g Neomycin (sulfate) CAS:1405-10-3 Formula:C23H52N6O25S3 Neomycin sulfate is an aminoglycoside antibiotic and calcium channel inhibitor. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.