Glycosyl compounds
Chem-Impex International, Inc. Octyl-b-D-thioglucopyranoside | MFCD00012189 | 5G
Octyl-b-D-thioglucopyranoside, MFCD00012189, 5G
Medchemexpress LLC 3-Deazaadenosine | 6736-58-9 | ≥99.0% | 266.26 | 1 MG
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase (SAHH), with a Ki of 3.9 μM. It exhibits anti-inflammatory, anti-proliferative, and anti-HIV activities.
- Inhibitor of S-adenosylhomocysteine hydrolase (SAHH)
- Anti-inflammatory activity
- Anti-proliferative activity
- Anti-HIV activity
Medchemexpress LLC 6-Azauridine triphosphate ammonium | C8H17N4O15P3 | 1 MG
6-Azauridine triphosphate ammonium is a nucleotide analog similar to uridine triphosphate. It is used to study the mechanism of RNA synthesis and transcription regulation.
- Purity of 95.0%
- Appears as a solid
- Color is white to off-white
- Soluble in H2O at 250 mg/mL (497.85 mM; requires ultrasonic)
Medchemexpress LLC 3-Deazaadenosine | 6736-58-9 | ≥99.0% | 266.26 | 5 MG
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM. It exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.
- Inhibits S-adenosylhomocysteine hydrolase (Ki of 3.9 μM).
- Possesses anti-inflammatory, anti-proliferative, and anti-HIV activity.
- Inhibits p24 antigen in HIV-1 infected peripheral blood mononuclear (PBMCs) cells.
- Inhibits LPS-induced expression of TNF-α mRNA and enhances nuclear translocation of NF-κB in RAW 264.7 cells.
- Suppresses vascular smooth muscle cell (VSMC) proliferation by interfering with Ras signaling.
Medchemexpress LLC 3-Deazaadenosine hydrochloride | 86583-19-9 | 99.67% | 302.72 | 5 MG
3-Deazaadenosine hydrochloride | 86583-19-9 | 99.67% | 302.72 | 5 MG
Apexbio Technology LLC 3-Deazaadenosine(Synonyms: 3-Deazaadenosine, 3-Deaza-adenosine, 3DA, Cordycepin analog, Tubercidin), 5mg, CAS: 6736-58-9.
3-Deazaadenosine (CAS 6736-58-9) is an inhibitor of S-adenosylhomocysteine (SAH) hydrolase an enzyme responsible for the reversible hydrolysis of SAH into adenosine and homocysteine Inhibition of SAH hydrolase by 3-Deazaadenosine (Ki 3 9 M) elevates intracellular SAH concentrations altering the SAH-to-SAM (S-adenosylmethionine) ratio and consequently suppressing SAM-dependent methyltransferase activities In vitro studies demonstrate its antiviral activity against Ebola and Marburg viruses in various primate and mouse cell lines Animal studies indicate protective efficacy against lethal Ebola infection in BALB/c mice Currently 3-Deazaadenosine remains in preclinical research
Selleck Chemical LLC 3-deazaadenosine
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3 9 M and has anti-inflammatory anti-proliferative and anti-HIV activity
Medchemexpress LLC 3-Deazaadenosine hydrochloride | 86583-19-9 | 99.7% | 302.72 | 1 ML
3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM. It exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity. This product is for research use only and not sold to patients.
- Inhibits S-adenosylhomocysteine hydrolase
- Shows anti-HIV effect
- Inhibits LPS-induced expression of TNF-α mRNA
- Enhances nuclear translocation of NF-κB
- Suppresses vascular smooth muscle cell (VSMC) proliferation
Medchemexpress LLC 1-deazaadenosine | 14432-09-8 | MFCD22683837 | 98.9% | 266.25 | C11H14N4O4 | 1 MG
1-Deazaadenosine is a nucleoside analogue used as a biochemical research reagent that potently inhibits adenosine deaminase (ADA) and is used in in vitro studies of ADA-related pathways and lymphoproliferative disorders.
- Potent adenosine deaminase (ADA) inhibitor with Ki = 0.66 μM.
- High purity: 98.9%.
- Molecular weight: 266.25 g/mol.
- Chemical formula: C11H14N4O4.
- White to off-white solid suitable for laboratory use.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent at -80°C (up to 6 months) or -20°C (up to 1 month).
Apexbio Technology LLC 5-Azacytidine 320-67-2 1g
5-Azacytidine is a cytidine analog compound that functions as an inhibitor of DNA methyltransferase (DNMT) Its mechanism involves incorporation into cellular DNA/RNA followed by covalent binding to DNMT through the formation of a bond between the C6 position of 5-Azacytidine and the thiol group of cysteine residues in DNMT enzymes leading to reduced DNMT activity and subsequent DNA demethylation In cellular studies involving multiple myeloma (MM) 5-Azacytidine exhibits cytotoxicity against MM-derived cell lines (MM 1S MM 1R RPMI-8266 RPMI-LR5 RPMI-Dox40) with reported IC50 values of approximately 1 5 mol/L 0 7 mol/L 1 1 mol/L 2 5 mol/L and 3 2 mol/L respectively as well as patient-derived MM cells (IC50 1 5 mol/L) This compound is widely used in cancer research to investigate epigenetic regulation mechanisms and DNA methylation pathways
Apexbio Technology LLC 6-AZURIDINE-1G
6-Azuridine (CAS No 54-25-1) is a nucleoside analog used in biomedical research particularly in antiviral and anticancer studies Originating from modifications of naturally occurring uridine it acts primarily by inhibiting nucleotide biosynthesis interfering with viral RNA replication and targeting pathways involved in cell proliferation Its in vitro activity is typically observed in the nanomolar to low micromolar range making it effective in disrupting viral ion channels and proliferation in cancer cell lines Common applications include use in cell culture models and animal studies to explore its therapeutic potential and to screen for new drugs Experimental concentrations typically depend on the specific research design