Monosaccharides
TARGETMOL CHEMICALS INC PROTAC BRD4 LIGAND-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET. purity: 99%
Selleck Chemical LLC Balsalazide disodium S3745-25mg
Balsalazide Disodium is the disodium salt form of balsalazide an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway
Selleck Chemical LLC Disodium Cromoglycate S1911-50mg
Disodium Cromoglycate (Gynazole FPL 670 (Cromolyn) Disodium Cromolyn sodium) is an antiallergic drug with IC50 of 39 g/mL
Selleck Chemical LLC NADH Disodium Salt Hydrate
NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis -oxidation and the citric acid cycle
Selleck Chemical LLC Eosin Y Disodium
Eosin Y is a form of eosin It is most commonly used as an acidic red stain for highlighting cytoplasm material in samples
Medchemexpress LLC USP7 Ligand-Linker Conjugates 1 | 671.83 | 25MG
USP7 Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate designed for the synthesis of PROTAC USP7 Degrader-1. This product incorporates a ligand for USP7 and a PROTAC linker, which recruits E3 ligases. PROTACs operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is intended for use as laboratory chemicals and in the manufacture of substances for research purposes only, to be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Incorporates a ligand for USP7
- Recruits E3 ligases
- Used for the synthesis of PROTAC USP7 Degrader-1
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
TARGETMOL CHEMICALS INC SIGMA-LIGAND-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM 19 nM at the DTG site and the PPP site respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor. purity: 100%
Sigma Aldrich Fine Chemicals Biosciences Glucose 6 phosphate Dehydr
Glucose 6-phosphate dehydrogenase (G-6-P-DH) is a key regulatory enzyme in the first step of the pentose phosphate pathway. G-6-P-DH is a glycoprotein with a molecular mass of 128 kDa (gel filtration).
Medchemexpress LLC Cromolyn (disodium) | 15826-37-6 | 100.0% | 25 MG
Cromolyn disodium is an orally active GSK-3β inhibitor (IC50 of 2.0 μM) and a mast cell stabilizer. It inhibits mediator release from mast cells, regulates reflex bronchoconstriction, and reduces non-specific bronchial hyperreactivity. Primarily used in bronchial asthma research, it also demonstrates anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective activities. This product is for research use only.
- Orally active GSK-3β inhibitor
- Mast cell stabilizer
- Inhibits mediator release from mast cells
- Regulates reflex bronchoconstriction
- Reduces non-specific bronchial hyperreactivity
- Used in bronchial asthma research
- Demonstrates anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective activities
- For research use only
Apexbio Technology LLC Carbenoxolone disodium 7421-40-1 10mM (in 1mL DMSO)
Carbenoxolone disodium (CAS 7421-40-1) is a small-molecule inhibitor targeting 11 -hydroxysteroid dehydrogenase (11 -HSD) It is designed to modulate glucocorticoid metabolism by suppressing the interconversion of corticosteroid hormones thereby regulating glucocorticoid access to steroid receptors Carbenoxolone disodium exerts its biological activity through inhibition of 11 -HSD enzymatic function In vitro studies demonstrate inhibitory activity with reported IC50 values ranging from 10 30 M depending on experimental conditions and target tissue Based on these pharmacological properties Carbenoxolone disodium holds research potential in neuroendocrine and cardiovascular studies exploring glucocorticoid-mediated signaling pathways
Medchemexpress LLC NSC-87877 (disodium) | 56932-43-5 | 98.0% | 503.42 | 50 MG
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases, with IC50 values of 0.318 μM and 0.355 μM for Shp2 and Shp1, respectively. It also inhibits dual-specificity phosphatase 26 (DUSP26).
- Potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases
- Inhibits dual-specificity phosphatase 26 (DUSP26)
- Inhibits DUSP26 function in NB cell lines
- Results in increased p53 phosphorylation and activation
- Possesses excellent anti-neuroblastoma activity in vivo
Medchemexpress LLC Sitagliptin (phosphate) | 654671-78-0 | 99.6% | 505.31 | 1 ML
Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. It blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, independent of DPP-4. It shows protective effects on pancreatic islet grafts in type 1 diabetes models and can be used for the study of type 1 and type 2 diabetes.
- Orally active and highly selective DPP4 inhibitor
- Blocks degradation of GLP-1 and GIP
- Increases active incretin levels
- Directly stimulates GLP-1 secretion
- Protective effects on pancreatic islet grafts
- Useful for type 1 and type 2 diabetes research
Medchemexpress LLC D-Mannose | 3458-28-4 | MFCD00064122 | 180.16 | 1 ML
D-Mannose is a C-2 superpolymer of glucose, naturally occurring in various plants and fruits, exhibiting both anti-inflammatory and antitumor properties. It is an endogenous metabolite and a carbohydrate that plays a crucial role in human metabolism.
- Endogenous metabolite
- Carbohydrate involved in human metabolism
- Important for glycosylation of specific proteins
- Exhibits anti-inflammatory activity
- Shows antitumor activity
- Supplied as a 10 mM solution in DMSO