Sugar acids and derivatives
Medchemexpress LLC D-Nmappd | 35922-06-6 | MFCD08062172 | 99.7% | 422.6 g/mol | C23H38N2O5 | 25MG
D-NMAPPD ((1R,2R)-B13) is a research-grade small-molecule acid ceramidase inhibitor that modulates NMDA receptor properties by enhancing endogenous ceramide production. It is used in biochemical and neurological research and has been reported to show anticancer activity in experimental studies. The compound is supplied in milligram-scale quantities with high reported purity suitable for laboratory applications.
- Inhibits acid ceramidase activity.
- Modulates NMDA receptor properties by enhancing endogenous ceramide production.
- Reported anticancer activity in experimental studies.
- High purity (~99.7%) suitable for research use.
- Molecular formula C23H38N2O5; molecular weight 422.6 g/mol.
- Available in milligram-scale package sizes for laboratory experiments.
Medchemexpress LLC 4-Methylumbelliferyl | 124223-99-0 | 10MG
4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside is a fluorogenic substrate for studying the enzymatic activity of -galactosidase 4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside is used to analyze enzyme activity in various biological samples helping scientists gain insight into the function of the enzyme in vivo 4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside can also be used to screen potential compounds to inhibit or activate this enzyme
Sigma Aldrich Fine Chemicals Biosciences Acetobromo alpha D glucose100G
Acetobromo alpha D glucose100G
Apexbio Technology LLC D-AP5(Synonyms: D-2-Amino-5-phosphonopentanoic acid, D-APV, D(-)-2-Amino-5-phosphonovaleric acid), 10mg, CAS: 79055-68-8.
D-AP5 (CAS 79055-68-8) is a selective antagonist of the NMDA receptor It competitively inhibits glutamate binding at the NMDA receptor site exhibiting an affinity constant (Kd) of approximately 1 4 M In animal research administration of D-AP5 leads to impairment in spatial learning tasks specifically causing deficits in sensorimotor function and spatial memory performance Due to its targeted action on NMDA receptors D-AP5 serves as an important pharmacological tool for studying glutamate-related synaptic plasticity learning and memory mechanisms
Medchemexpress LLC Integrin alpha 8 bet 10ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-His labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 His) has molecular weight of 120-140 kDa 100-120 kDa respectively
Medchemexpress LLC 2H-1-benzopyran-2-one, 7-(beta-D-glucopyranosyloxy)-4-methyl- | 18997-57-4 | MFCD00063694 | 99.9% | 338.31 g/mol | C16H18O8 | 10MM 1ML
4-Methylumbelliferyl β-D-glucopyranoside is a coumarin-based fluorogenic substrate used to measure β-glucosidase and related enzyme activities. Enzymatic hydrolysis releases the fluorescent 4-methylumbelliferone (4-MU), which emits near 445-454 nm; excitation is pH-dependent. The product is supplied as a 10 mM solution in DMSO (1 mL) and is suitable for fluorescence-based biochemical assays.
Medchemexpress LLC 4-Methylumbelliferyl 100mg | 18323-58-5 | 440.61 g·mol^-1 | C28H40O4 | 100 MG
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. Upon enzymatic hydrolysis, it liberates 4-methylumbelliferone (4-MU), enabling sensitive fluorometric detection and kinetic assays (Ex/Em 320/450 nm).
- Provides a fluorogenic readout upon lipase-catalyzed hydrolysis.
- Releases 4-methylumbelliferone with Ex/Em 320/450 nm for sensitive detection.
- High chemical purity suitable for enzymatic assays.
- Stable when stored at -20°C and protected from light; solvent stability guidelines available.
- Available in multiple pack sizes to support assay development and scale-up.
Medchemexpress LLC Integrin alpha X bet 100ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His labeled tag Integrin alpha X beta 2 Protein Human (HEK293 His) has molecular weight of 130-150 kDa (ITGAX) 85-96 kDa (ITGB2) respectively
Apexbio Technology LLC Beta-Lapachone 4707-32-8 10mg
Beta-Lapachone (CAS 4707-32-8) is a small molecule inhibitor of DNA topoisomerase I In DNA unwinding assays beta-Lapachone suppresses topoisomerase I-mediated DNA relaxation at concentrations as low as 1 M without inhibiting topoisomerase II or inducing topoisomerase I-dependent DNA cleavage It exhibits broad cytotoxicity against human cancer cell lines such as AD2780s HT-29 DLD G480 and MCF-7 with IC50 values ranging from 2 to 5 M The compound induces cell death through cytochrome c release triggering both apoptosis and necrosis and affects cell cycle progression causing S-phase and G2/M arrest in different carcinoma cell models Beta-Lapachone is widely utilized in studies investigating topoisomerase I inhibition cancer cell cytotoxicity and cell cycle regulation
Selleck Chemical LLC Heparin sodium S1346-1g
Heparin sodium a sulfated polysaccharide belonging to the family of glycosaminoglycans has numerous important biological activities associated with its interaction with diverse proteins Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors including thrombin and factor Xa Heparin prevents the induction of autophagy
Medchemexpress LLC Aloeresin D | 105317-67-7 | MFCD32004290 | 99.5% | 556.56 | C29H32O11 | 10 MG
Aloeresin D is a chromone glycoside isolated from Aloe vera that inhibits β-secretase (BACE1) with a reported IC50 of 39 μM. It is supplied as a purified research compound with defined solubility and storage recommendations for biochemical and pharmacological studies.
- Chromone glycoside isolated from Aloe vera.
- Inhibits β-secretase (BACE1); IC50 = 39 μM.
- High purity (≈99.5%).
- Molecular formula C29H32O11; molecular weight 556.56 g/mol.
- Soluble in DMSO (250 mg/mL); reported in vivo solubility ≥2.08 mg/mL.
- Solid storage: 4°C, sealed, protected from moisture and light.
Medchemexpress LLC Bet bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 | C24H20ClN5O2 | 5 MG
BET bromodomain inhibitor (CAS 1505453-59-7) is a high-purity research compound that targets BET family bromodomains, with reported activity against BRD4 (IC50 = 14 nM). Supplied as a small solid pack for laboratory use, it is intended for in vitro and preclinical studies of epigenetic regulation and tumor cell biology.
- High purity (99.53%).
- Reported BRD4 potency: IC50 = 14 nM.
- Molecular formula C24H20ClN5O2; molecular weight 445.90.
- Supplied as a 5 mg solid suitable for assay development.
- Useful for epigenetic and tumor research applications.
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | MFCD00872153 | 99.9% | 568.53 | C28H28N2O11 | 5 MG
SN-38 glucuronide is the glucuronidated, inactive metabolite of the anticancer agent irinotecan, supplied for research use to study drug metabolism, pharmacokinetics, and cellular resistance mechanisms. The substance is characterized by CAS 121080-63-5, molecular formula C28H28N2O11, and molecular weight 568.53.
- High purity suitable for analytical and biological studies.
- Useful for metabolism and pharmacokinetic assays.
- Enables investigation of cellular resistance to SN-38.
- Suitable as a reference standard for LC-MS/MS and HPLC methods.
- Provided in defined small-mass pack sizes for laboratory use.
AdipoGen C9-L-HSL
Chemical. CAS 177158-21-3. Formula C13H23NO3. MW 241.33. N-Nonanoyl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression and affecting cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
Apexbio Technology LLC MG 149 1243583-85-8 10mg
MG 149 (CAS 1243583-85-8) is a small molecule inhibitor of histone acetyltransferases (HATs) exhibiting selectivity for MYST family members Tip60 and MOF with reported IC50 values of 74 M and 47 M respectively As an alkylsalicylate derivative MG 149 competitively binds to the acetyl-CoA pocket of Tip60 thereby impeding its enzymatic activity In cell-based assays using HeLa nuclear extracts MG 149 inhibited HAT activity displaying more pronounced effects on histone H3 acetylation compared to H4 Additionally transcriptomic analyses indicate that MG 149 modulates p53 and NF- B signaling pathways highlighting its utility in studying epigenetic regulation and signaling in cellular models