Sugar acids and derivatives
Sigma Aldrich Fine Chemicals Biosciences Polygalacturonic acid | 25990-10-7 | MFCD00131972 | 25g
Polygalacturonic acid | Purity: 85% | 25990-10-7 | MFCD00131972 | 25g
Medchemexpress LLC S-nitroso-N-acetylpenicillamine | 79032-48-7 | MFCD00153852 | 95.0% | 220.25 | C7H12N2O4S | 10 MG
D-SNAP (S-nitroso-N-acetylpenicillamine) is an S-nitrosothiol nitric oxide donor used in biochemical and cell biology research to deliver controlled NO release and to probe NO-mediated signaling and oxidative stress. It is provided as a solid for preparation of stock solutions and requires light-protected, inert storage for stability.
- Generates nitric oxide under physiological conditions.
- Typical purity 95.0%.
- Available in small milligram quantities for research use.
- Stable when stored at -20°C, protected from light and under nitrogen.
- Provides controlled and reproducible NO release for cellular assays.
Medchemexpress LLC Hederacoside D | 760961-03-3 | MFCD22572710 | 99.3% | 1075.24 | C53H86O22 | 10 MG
Hederacoside D is a bioactive triterpenoid saponin isolated from Hedera helix (common ivy). It is provided as a white to off-white solid for research and analytical applications, with high purity and characterized molecular properties. Solubility data indicate excellent solubility in DMSO and formulations suitable for in vivo dosing studies.
- Bioactive triterpenoid saponin from Hedera helix.
- High purity (99.3%).
- Molecular formula C53H86O22 and molecular weight 1075.24.
- Soluble in DMSO at 100 mg/mL (may require ultrasonic).
- Supplied in small research pack sizes such as 10 mg.
Apexbio Technology LLC Cyclosporin D 63775-96-2 25mg
Cyclosporin D (CAS 63775-96-2) is a structural analogue of Cyclosporin A with comparatively reduced immunosuppressive activity Mechanistically it weakly inhibits lymphocyte proliferation induced by mitogens such as PHA PWM PMA and Ca 2 and suppresses Ca 2 /calmodulin-dependent phosphorylation of elongation factor 2 (EF-2) in mouse pancreatic cells In preclinical models Cyclosporin D overcomes Adriamycin resistance in multidrug-resistant ovarian cancer cells and inhibits TPA-induced ear edema and alkaline phosphatase activity in mice Additionally it displays inhibitory effects on the growth of malarial parasites both in vitro and in vivo Cyclosporin D serves as a standard in Cyclosporin A quantification and as a research tool in immunology oncology and antiparasitic studies
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | C106H162FN9O37 | 10 MG
OBI-992 drug-linker is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis. It links the TOP1 inhibitor exatecan to a cleavable linker to enable targeted delivery of the payload; preclinical studies report antitumor activity in mouse and PDX models. Supplied as a solid for research use, the product includes specified purity and storage recommendations for laboratory handling.
- Composed of exatecan linked to a cleavable linker.
- Demonstrated antitumor activity in preclinical models.
- High molecular weight compound suitable for ADC synthesis.
- Provided as a white to yellow solid.
- Purity 96.6%.
- Molecular weight 2173.46.
- Storage: sealed, away from moisture and light; in solvent -80°C for 6 months, -20°C for 1 month.
- Supplied in a 10 mg package for research use.
Medchemexpress LLC Integrin alpha V bet 50ug | 50ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Medchemexpress LLC Zen-3694 | 1643947-30-1 | 99.7% | 333.39 | C19H19N5O | 25MG
BET-IN-19 is a potent small-molecule BET bromodomain inhibitor for research use. It inhibits hIL-6 mRNA transcription and c-myc activity in AML MV4-11 cells (IC50 ≤ 0.3 μM). The compound has molecular formula C19H19N5O, molecular weight 333.39, and reported purity ≈99.7%; it is supplied as a powder and is typically stored at -20°C (powder) or at -80°C in solvent for longer term.
Medchemexpress LLC Aloeresin D | 105317-67-7 | MFCD32004290 | 99.5% | 556.56 | C29H32O11 | 10 MG
Aloeresin D is a chromone glycoside isolated from Aloe vera that inhibits β-secretase (BACE1) with a reported IC50 of 39 μM. It is supplied as a purified research compound with defined solubility and storage recommendations for biochemical and pharmacological studies.
- Chromone glycoside isolated from Aloe vera.
- Inhibits β-secretase (BACE1); IC50 = 39 μM.
- High purity (≈99.5%).
- Molecular formula C29H32O11; molecular weight 556.56 g/mol.
- Soluble in DMSO (250 mg/mL); reported in vivo solubility ≥2.08 mg/mL.
- Solid storage: 4°C, sealed, protected from moisture and light.
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f