Sugar acids and derivatives
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 25 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM. It exhibits anti-cancer activity. In vitro studies show that BET-IN-14 (Compound 171) has anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM), particularly in MM.1S, Ty-82, MV-4-11, and KG-1 cells. In vivo, BET-IN-14 (50 and 100 mg/kg, p.o., qd) inhibits tumor growth in MV-4-11 xenograft models by 60.36%.
- Orally active pan BET inhibitor with high potency (IC50 of 5.35 nM)
- Displays anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM)
- Effective in MM.1S, Ty-82, MV-4-11, and KG-1 cells
- Inhibits tumor growth in MV-4-11 xenograft models by over 60% at tested dosages
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 5 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein expressed by HEK293 with C-Avi C-His labeled tag Integrin alpha V beta 5 Protein Human (HEK293 His-Avi) has molecular weight of 85-160 kDa
Medchemexpress LLC D-Glucuronic acid | 99.9% | 240.09 g·mol⁻¹ | 13C6H11NaO8 | 10 MG
13C6-labeled D-glucuronic acid sodium salt monohydrate provided as a stable-isotope internal standard for metabolomics and biochemical research. The material is the sodium salt monohydrate of D-glucuronic acid, isotopically labeled on all six carbons (13C6), and supplied as a high-purity dry solid.
- 13C6 isotopic labeling for tracer and internal standard use.
- High purity (HPLC) - 99.9%.
- Molecular weight 240.09 g·mol⁻¹ and formula 13C6H11NaO8.
- Suitable for LC-MS and metabolomics workflows as a standard or tracer.
- Supplied as a stable dry solid for controlled storage.
Medchemexpress LLC Garcinone D | 107390-08-9 | 25 MG
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways and an inhibitor of CDK2/CyclinE1. It promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression, and by enhancing the Nrf2/HO-1 signaling pathway. Additionally, it blocks the tumor cell cycle by inhibiting CDK2/CyclinE1.
- Activates STAT3/Cyclin D1 and Nrf2/HO-1 pathways
- Inhibits CDK2/CyclinE1 (IC50 is 28.23 μM)
- Promotes neural stem cell proliferation
- Blocks tumor cell cycle
- Can inhibit prostate and breast cancer
Medchemexpress LLC D-Nmappd | 35922-06-6 | MFCD08062172 | 99.7% | 422.6 g/mol | C23H38N2O5 | 25MG
D-NMAPPD ((1R,2R)-B13) is a research-grade small-molecule acid ceramidase inhibitor that modulates NMDA receptor properties by enhancing endogenous ceramide production. It is used in biochemical and neurological research and has been reported to show anticancer activity in experimental studies. The compound is supplied in milligram-scale quantities with high reported purity suitable for laboratory applications.
- Inhibits acid ceramidase activity.
- Modulates NMDA receptor properties by enhancing endogenous ceramide production.
- Reported anticancer activity in experimental studies.
- High purity (~99.7%) suitable for research use.
- Molecular formula C23H38N2O5; molecular weight 422.6 g/mol.
- Available in milligram-scale package sizes for laboratory experiments.
Medchemexpress LLC 4-methylumbelliferyl β-d-glucopyranoside | 18997-57-4 | MFCD00063694 | 99.9% | 338.31 g/mol | C16H18O8 | 1G
4-Methylumbelliferyl β-D-Glucopyranoside is a fluorogenic β-D-glucoside substrate used to measure β-glucosidase activity. Enzymatic cleavage releases 4-methylumbelliferone (4-MU), a highly fluorescent reporter (emission 445-454 nm); excitation maxima are pH-dependent (330, 370, 385 nm at pH 4.6, 7.4, 10.4). The product is supplied as a solid and as a 10 mM solution in DMSO for convenient assay setup.
- Fluorogenic substrate for β-glucosidase assays.
- Releases 4-methylumbelliferone for sensitive fluorescence detection.
- High reported purity (99.87%).
- Available as solid and 10 mM solution in DMSO.
- Suitable for biochemical and cell-based enzyme activity assays.
- Molecular weight 338.31 g/mol; formula C16H18O8.
- Pack sizes suitable for assay workflows, including 1 g solid options.
Medchemexpress LLC Glucuronic acid sodium | 7182-77-6 | 1 MG
Glucuronic acid sodium is a polysaccharide that exhibits anti-inflammatory activity, supporting the healing of ulcerative colitis. It also enhances the intestinal barrier by upregulating tight junction proteins like ZO-1 and Occludin. Additionally, it modulates gut microbiota by increasing beneficial bacterial populations while suppressing harmful ones.
- Exhibits anti-inflammatory activity
- Supports healing of ulcerative colitis
- Enhances intestinal barrier function
- Modulates gut microbiota
- Increases beneficial bacterial populations
- Suppresses harmful bacterial populations
Medchemexpress LLC Bruceine D | 21499-66-1 | 25 MG
Bruceine D is a Notch inhibitor that exhibits anti-cancer activity and induces apoptosis in various human cancer cells. It also serves as an effective botanical insect antifeedant with systemic properties, leading to potent pest growth inhibition. Additionally, Bruceine D demonstrates strong anthelmintic activity against *D. intermedius* with an EC50 value of 0.57 mg/L.
- Notch inhibitor
- Induces apoptosis in several human cancer cells
- Effective botanical insect antifeedant with systemic properties
- Causes potent pest growth inhibitory activity
- Strong anthelmintic activity against *D. intermedius*
- Purity: 99.50%
- Appearance: Solid, white to off-white
![eMolecules 894095-98-8 | ??-D-glucuronide-pNP-carbonate | Ambeed913.842 | C45H43N3O18 | 98.000 | COC(=O)[C@H]1O[C@@H](Oc2ccc(COC(=O)Oc3ccc(cc3)N(=O)=O)cc2NC(=O)CCNC(=O)OCC2c3ccccc3-c3ccccc23)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O | 100mg | 847281787](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126835.jpg-250.jpg)
eMolecules 894095-98-8 | ??-D-glucuronide-pNP-carbonate | Ambeed913.842 | C45H43N3O18 | 98.000 | COC(=O)[C@H]1O[C@@H](Oc2ccc(COC(=O)Oc3ccc(cc3)N(=O)=O)cc2NC(=O)CCNC(=O)OCC2c3ccccc3-c3ccccc23)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O | 100mg | 847281787
??-D-glucuronide-pNP-carbonate | Ambeed | 894095-98-8913.842 | C45H43N3O18 | 98.000 | COC(=O)[C@H]1O[C@@H](Oc2ccc(COC(=O)Oc3ccc(cc3)N(=O)=O)cc2NC(=O)CCNC(=O)OCC2c3ccccc3-c3ccccc23)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O | 100mg | 847281787
Apexbio Technology LLC MG 149 1243583-85-8 10mg
MG 149 (CAS 1243583-85-8) is a small molecule inhibitor of histone acetyltransferases (HATs) exhibiting selectivity for MYST family members Tip60 and MOF with reported IC50 values of 74 M and 47 M respectively As an alkylsalicylate derivative MG 149 competitively binds to the acetyl-CoA pocket of Tip60 thereby impeding its enzymatic activity In cell-based assays using HeLa nuclear extracts MG 149 inhibited HAT activity displaying more pronounced effects on histone H3 acetylation compared to H4 Additionally transcriptomic analyses indicate that MG 149 modulates p53 and NF- B signaling pathways highlighting its utility in studying epigenetic regulation and signaling in cellular models
Medchemexpress LLC Integrin alpha X bet 50ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His labeled tag Integrin alpha X beta 2 Protein Human (HEK293 His) has molecular weight of 130-150 kDa (ITGAX) 85-96 kDa (ITGB2) respectively
Medchemexpress LLC Magenta-β-D-GlcA (5-bromo-6-chloro-3-indolyl β-D-glucuronide cyclohexylammonium) | 144110-43-0 | 99.8% | 521.79 | 25 MG
Magenta-β-D-GlcA is a biochemical reagent suitable for life science research. This organic compound is intended for research use only and not for patient use. It typically appears as a white to off-white solid.
- Can be used as a biological material or organic compound
- Intended for life science related research
- Appears as a white to off-white solid
- Research use only
- Not sold to patients
- Solubility in DMSO: 50 mg/mL (needs sonication; use newly opened DMSO)
- Stock solution storage: -80°C for 6 months, or -20°C for 1 month (sealed, away from moisture)
- Product storage: -20°C, sealed, away from moisture
Medchemexpress LLC LA-CB1 | 3032908-44-1 | 98.2% | 527.98 | 25 MG
LA-CB1 | 3032908-44-1 | 98.2% | 527.98 | 25 MG