Sugar acids and derivatives
Medchemexpress LLC IL-1RA/IL-1F3 Porci 5ug | 5ug
IL-1RA/IL-1F3 proteins are powerful anti-inflammatory antagonists in the interleukin 1 family specifically targeting the pro-inflammatory cytokines IL1B and IL1A This protein counteracts the inflammatory effects of IL1 playing a critical role in preventing immune dysregulation and preventing uncontrolled systemic inflammation triggered by a variety of innate irritants including pathogens IL-1RA/IL-1F3 Protein Porcine is the recombinant Porcine-derived IL-1RA/IL-1F3 protein expressed by E coli with tag free
Medchemexpress LLC D-3263 hydrochloride | 1008763-54-9 | MFCD22665741 | 98.0% | 409.95 | C21H32ClN3O3 | 10 MG
D-3263 hydrochloride is an enteric-coated, orally bioavailable agonist of transient receptor potential melastatin member 8 (TRPM8). It binds and activates TRPM8, modulates calcium and sodium flux, and has been investigated for potential antineoplastic effects and modulation of androgen-related pathways.
- Orally bioavailable TRPM8 agonist suitable for in vivo studies.
- Enteric-coated formulation for improved gastrointestinal stability.
- High purity (98.0%) supports reproducible experimental results.
- Soluble in DMSO and formulatable for common in vivo vehicles.
- Stable when stored sealed at 4°C; solvent stability at -80°C for extended storage.
Medchemexpress LLC Zen-3694 | 1643947-30-1 | 99.7% | 333.39 | C19H19N5O | 25MG
BET-IN-19 is a potent small-molecule BET bromodomain inhibitor for research use. It inhibits hIL-6 mRNA transcription and c-myc activity in AML MV4-11 cells (IC50 ≤ 0.3 μM). The compound has molecular formula C19H19N5O, molecular weight 333.39, and reported purity ≈99.7%; it is supplied as a powder and is typically stored at -20°C (powder) or at -80°C in solvent for longer term.
Medchemexpress LLC MAC-545496 | 838810-96-1 | 98.0% | 10 MM * 1 ML
MAC-545496 is a potent nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), demonstrating strong binding affinity (Kd ≤ 0.1 nM). It acts as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant Staphylococcus aureus (MRSA) strains, and is intended for research use only.
- Potently synergizes with Cefuroxime and Oxacillin against S. aureus clinical isolates.
- Inhibits mprF expression in a concentration-dependent manner (IC50 of 0.0376 μg/mL).
- Inhibits citrate-induced biofilm formation in wild-type strains.
- Effective as monotherapy for MRSA-infected Galleria mellonella larvae, increasing survival.
Medchemexpress LLC PROTAC BET-binding moiety 2 | 916493-82-8 | 99.77% | 444.89 | 1 ML
PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain. It is for research use only.
- Inhibitor of BET bromodomain.
- Appearance: solid
- Color: white to off-white
Medchemexpress LLC Azido-PEG4-beta-D-glucose | 1609083-15-9 | 99.9% | 381.38 | 25 MG
Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This click chemistry reagent contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide functional group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Intended for research use only
Medchemexpress LLC BSJ-04-122 | 2513289-74-0 | 99.9% | 313.74 g/mol | C15H12ClN5O | 10 MG
BSJ-04-122 is a covalent dual inhibitor of the MAP kinase kinases MKK4 and MKK7 developed for research use. It demonstrates potent enzymatic inhibition (IC50 4 nM for MKK4; 181 nM for MKK7) and is applied in studies of cancer biology and MAPK signaling. The compound is supplied as a solid with high chemical purity and recommended storage conditions for both powder and solution forms.