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Filtered Search Results
Medchemexpress LLC RK-701 | 2648855-18-7 | C26H30N4O3 | 25 MG
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RK-701 is a highly selective and non-genotoxic inhibitor of G9a (IC50 value of 23-27 nM). It selectively up-regulates HbF, γ-Globin, and BGLT3 expression, while down-regulating H3K9me2 expression. It also inhibits BCL11A and ZBTB7A. This product is intended for research use only.
- Highly selective and non-genotoxic G9a inhibitor
- Up-regulates HbF, γ-globin, and BGLT3 expression
- Down-regulates H3K9me2 expression
- Inhibits BCL11A and ZBTB7A
- Exhibits antiproliferative activity against human MOLT-4 cells (GI50: 21.3 nM)
- Increases proportion of HbF expressing cells
- Demonstrates low toxicity
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Medchemexpress LLC TNF RII/TNFRSF1B Cy 10ug
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TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF- ) TNFRII has pro-apoptotic function TNFRII recruits TRAF2 induces gene expression and intensively crosstalks with TNF-R1 TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI TNF RII/TNFRSF1B Protein Cynomolgus/Rhesus Macaque (HEK293 His) is expressed by HEK293 with 6 His tag at the C-terminus[1]
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Medchemexpress LLC CY 208-243 | 100999-26-6 | >99.9% | 274.36 | 1 MG
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CY 208-243 is a selective dopamine D1 receptor agonist that demonstrates antiparkinsonian activity. It is intended for research purposes only. In vivo studies show that pretreatment with CY 208-243 prevents the increase of dopamine (DA) release and metabolism induced by the D-1 antagonist, SCH 23390.
- Selective dopamine D1 receptor agonist
- Exhibits antiparkinsonian activity
- Prevents increase of DA release and metabolism
- For research use only
- Appearance: Solid, white to off-white
- Solubility (in vitro): DMSO: 50 mg/mL
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
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Medchemexpress LLC TNF-alpha/TNFSF2 Cy 10ug | 10ug
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
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Medchemexpress LLC IL-2R beta/CD122 Cy 20ug | 20ug
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IL-2R beta (CD122) a type cytokine receptor expressed on T lymphocytes is a receptor for IL-2 (Kd 1 nM approximately)[1] IL-2R beta mediates T cell immune responses such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2] IL-2R beta/CD122 Protein Cynomolgus (HEK293 His) is a recombinant cynomolgus IL-2R beta (A27-D239) with a C-Terminal His tag which is produced in HEK 293
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Selleck Chemical LLC RK-701-E1607-25MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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RK-701 is a highly selective potent and low-toxicity inhibitor of histone methyltransferases G9a and GLP1 with IC50 values of 23-27 nM and 53 nM RK-701 treatment induces fetal globin expression in human erythroid cells and in mice and plays an essential role in -globin induction RK-701 is used in the research of sickle cell disease
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Medchemexpress LLC 4-[(Z)-[4-oxo-2-sulfanylidene-3-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid | 1073612-91-5 | MFCD31619349 | 99.6% | 423.43 g/mol | C19H12F3NO3S2 | 100 MG
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CY-09 is a selective, direct inhibitor of the NLRP3 inflammasome used for biochemical and cellular research. It binds the ATP-binding motif of the NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, preventing inflammasome assembly and activation. For research use only.
- Selective NLRP3 inhibitor targeting the NACHT domain
- Inhibits NLRP3 ATPase activity to block inflammasome activation
- High purity compound suitable for biochemical and cellular assays
- Available as a solid powder, stable under recommended storage conditions
- Supplied in research-scale pack sizes for laboratory experiments
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Sigma Aldrich Fine Chemicals Biosciences SP SepharoseR Fast Flow Cy
SP Sepharose(R) Fast Flow is a strong cation exchanger based on the well established Sepharose(R) Fast Flow ion exchange platform extensively used for preparative protein separations in both research and industrial applications.SP Sepharose(R) Fast Flow is part of the Sepharose(R) Fast Flow ion exchange platform which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of crosslinked 6% agarose beads with sulphopropyl (Q) strong cation exchange groups. SP Sepharose(R) Fast Flow has high chemical stability allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with SP Sepharose(R) Fast Flow is straight forward and the medium is available in a range of pre-packed process development tools.As member of the BioProcess media range SP Sepharose(R) Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.
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Medchemexpress LLC TNF-alpha/TNFSF2 Cy 100ug
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TNF-alpha/TNFSF2 protein binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR It induces tumor cell death fever cachexia cell proliferation and cell differentiation It also causes insulin resistance and GKAP42 protein degradation in adipocytes Additionally it plays a role in angiogenesis osteoclastogenesis and IL12 production in dendritic cells TNF-alpha/TNFSF2 Protein Cynomolgus (N-His) is the recombinant cynomolgus-derived TNF-alpha/TNFSF2 protein expressed by E coli with N-6 His labeled tag
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Medchemexpress LLC TNF-alpha/TNFSF2 Cy 100ug | 100ug
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 3-cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)- | 31906-04-4 | MFCD00019423 | 97.8% | 210.31 | C13H22O2 | 250 MG
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Hydroxyisohexyl 3-cyclohexene carboxaldehyde is an aldehyde fragrance ingredient used as a hapten probe and analytical reference in research settings. Supplied as a colorless to light-yellow liquid, it is employed in contact allergy studies, patch-testing research, and analytical method development.
- Liquid, colorless to light yellow appearance.
- Molecular formula C13H22O2; molecular weight 210.31.
- Purity 97.8% suitable for analytical and research use.
- Available in multiple pack sizes to accommodate laboratory needs.
- Serves as a hapten probe in immunological and contact allergy investigations.
- Appropriate for reference standard and method development applications.
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Sigma Aldrich Fine Chemicals Biosciences Eubacteria FISH probe Cy
Fluorescent In Situ Hybridization technique (FISH) is based on the hybridization of fluorescent labeled oligonucleotide probe to a specific complementary DNA or RNA sequence in whole and intact cells.1 Microbial FISH allows the visualization identification and isolation of bacteria due to recognition of ribosomal RNA also in unculturable samples.2 FISH technique can serve as a powerful tool in the microbiome research field by allowing the observation of native microbial populations in diverse microbiome environments such as samples from human origin (blood3 and tissue4) microbial ecology (solid biofilms5 and aquatic systems6) and plants7. Prokaryotic single cell life forms are divided into two domains called Bacteria and Archaea originally categorized as Eubacteria and Archaebacteria.8 However both terms Eubacteria and Bacteria are still being used in microbiology.Eubacteria probe recognizes most bacteria as it is complementary to a portionof 16S rRNA found in almost all bacteria
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Cyanox CY 1790 10mM 1mL | 40601-76-1 | 699.9 g/mol | C42H57N3O6 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Cyanox CY 1790 is a triazine-based, sterically hindered phenolic antioxidant used to improve oxidative and thermal stability of polyolefins and other engineering plastics. It is supplied as a 10 mM solution in a 1 mL vial for laboratory research and material degradation studies.
- Triazine-based hindered phenolic antioxidant for polymer stabilization
- Provides processing and thermal stability during extrusion and molding
- Offers resistance to gas-fade (chlorine dioxide) and reduced extraction
- Low color contribution for color-sensitive applications
- Applicable to polyethylene, polypropylene, polyurethane, and polyester
- Supplied as a 10 mM solution in a 1 mL vial for research use
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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BIOHIPPO Research Grade Anti-Human HGF Biosimilar Antibody (TAK-701), 100 µg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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TAK-701 is a research-grade biosimilar antibody targeting HGF. It reacts with Human. Suitable for ELISA, FACS, Functional assay, Research in vivo. This research-grade biosimilar supports comparability, functional, PK/PD and immunogenicity studies. Supplied as 100 ug.
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Medchemexpress LLC Cy-09 | 1073612-91-5 | MFCD31619349 | 99.6% | 423.43 g/mol | C19H12F3NO3S2 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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CY-09 is a small-molecule inhibitor of the NLRP3 inflammasome (CAS 1073612-91-5) supplied as a ready-to-use 10 mM solution in DMSO for research applications. It binds the ATP-binding motif of the NLRP3 NACHT domain to inhibit ATPase activity and suppress inflammasome assembly and activation. For research use only.
- Ready-to-use 10 mM solution in DMSO.
- Supplied volume 1 mL per vial.
- High reported purity (99.58%).
- Molecular weight 423.43 g/mol; formula C19H12F3NO3S2.
- Certificate of analysis and safety data sheet available.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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