Glycerolipids
eMolecules Diglycerol | 627-82-7 | MFCD00049316 | 100g
Combi-Blocks, Inc. | Diglycerol | 100g | 586074155 | HA-8944 | 95.000 | 627-82-7 | MFCD00049316 | 166.173 | C6H14O5
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Medchemexpress LLC Tributyrin (glyceryl tributyrate) | 60-01-5 | 98.91% | 302.36 | 5 ML
Tributyrin (Glyceryl tributyrate) is a neutral short-chain fatty acid triglyceride that serves as a stable and rapidly absorbed proagent of Butyric Acid. It diffuses through biological membranes and is metabolized by intracellular lipases, which releases effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic, and differentiation-inducing effects.
- Enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells.
- Induces differentiation, growth arrest, and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines.
- Attenuates metabolic and inflammatory changes associated with obesity through a GPR109A-dependent mechanism.
- Alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice.
TARGETMOL CHEMICALS INC 1 2-Distearoyl-sn-glycero-3-ph
Also available in 100 mg, 200 mg and bulk. Please contact Fisher for quotes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system. Purity 99.53%
Medchemexpress LLC (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium | 124011-52-5 | 100.0% | 100 MG
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid that can be used for drug delivery and liposome synthesis. It can induce Tregs specific for liposomes' cargo and is taken up by antigen-presenting cells mediated via complement component 1q (C1q).
- Anionic phospholipid
- Used for drug delivery and liposome synthesis
- Liposomes containing this compound can induce antigen-specific Tregs
- Taken up by antigen-presenting cells mediated via complement component 1q (C1q)
- Can reduce plaque formation and increase plaque stability in atherosclerotic mice
Medchemexpress LLC Glyceryl 1-monooctanoate | 502-54-5 | 99.0% | 218.29 | 5 MG
Glyceryl 1-monooctanoate is a glycerol monolaurate derivative and a broad-spectrum antimicrobial. It suppresses the growth of pathogenic yeast and both Gram-positive and Gram-negative bacteria. This makes it suitable for various laboratory applications.
- Broad-spectrum antimicrobial activity.
- Suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis).
- Suppresses the growth of Gram-positive bacteria (Staphylococcus aureus).
- Suppresses the growth of Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae).
- Antifungal activity against saprophytic fungi (Aspergillus niger, Penicillium roqueforti, Penicillium jensenii, Alternaria sp., Phoma sp.).
- Antifungal activity against pathogenic fungi (Trichophyton mentagrophytes and Trichophyton rubrum).
Sigma Aldrich Fine Chemicals Biosciences Triacetin 99 fCC fG25KG
Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams nonalcoholic beverages and baked goods.
Medchemexpress LLC Triolein-13C3 | 82005-46-7 | 98.0% | 888.41 g/mol | C5413C3H104O6 | 10 MG
Triolein-13C3 is the 13C-labeled form of triolein, a symmetrical triacylglycerol used as a stable isotope standard in analytical and biochemical workflows. It enables isotopic tracing and mass-spectrometry differentiation while maintaining the chemical characteristics of native triolein. The supplier provides purity, storage, and supporting documentation for traceability.
- Provides stable isotope labeling for mass-spectrometry studies.
- High purity suitable for analytical use.
- Available in small, weighed packs for standards preparation.
- Datasheet and certificate of analysis available for quality assurance.
- Storage instructions supplied to preserve stability.
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.0% | 566.60 | 25 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. For research use only. We do not sell to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity toward MLL fusion protein transformed cells, with no effect (up to 6 μM) on control cell lines HL-60 and HM-2 that do not harbor MLL translocations.
- Binds to menin with low nanomolar affinity (Kd=6.5 nM).
- Potent cellular activity due to improved binding affinity to menin and possibly increased cell membrane permeability.
- Results in strong down-regulation of Hoxa9 and Meis1 gene expression.
- In vivo, it causes an approximately 80% reduction in MV4;11 tumor volume without significant toxicity.
- Demonstrates improved exposure (AUC values), Cmax, and lowest clearance in blood plasma.
- Has a half-life of about 1.6 h and high oral bioavailability (~50%).
Medchemexpress LLC Trielaidin 50mg
TrielaidinIt is an organic compound belonging to the class of triacylglycerols It consists of three molecules of elaidic acid esterified to the glycerin backbone with a mild fatty smell TrieladinIt has a variety of applications in the cosmetic and personal care industries especially as an emollient and conditioning agent in skin and hair care products Additionally it is used as a lubricant and surfactant in industrial settings
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.2% | 566.60 | 1 ML
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits menin and MLL fusion proteins interaction
- Potent cellular activity with improved binding affinity to menin
- Strong down-regulation of Hoxa9 and Meis1 genes expression
- Reduces tumor volume by approximately 80% in mice xenograft models
- Improved exposure (AUC values), Cmax, and lowest clearance
- Half-life: approximately 1.6 hours
- Oral bioavailability: approximately 50%
Medchemexpress LLC Tristearin | 555-43-1 | ≥98.0% | 500 MG
Tristearin (Glycerol tristearate) is a triglyceride derived from three units of stearic acid. It is commonly used as a solid-lipid nanoparticle (SLN) component for constructing drug delivery carriers, and has been shown to increase the cellular uptake rate of carried drugs, thereby enhancing drug efficacy.
- Triglyceride derived from stearic acid
- Used as a solid-lipid nanoparticle (SLN) component
- Increases cellular uptake rate of carried drugs
- Enhances drug efficacy
eMolecules (S)-6-(((Allyloxy)carbonyl)amino)-2-aminohexanoic acid hydrochloride | 147529-99-5 | MFCD09749825 | 1g
Ambeed | (S)-6-(((Allyloxy)carbonyl)amino)-2-aminohexanoic acid hydrochloride | 1g | 602850222 | A483657 | | 147529-99-5 | MFCD09749825 | 266.720 | C10H19ClN2O4
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Medchemexpress LLC 1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluor... | 1857417-10-7 | 98.2% | 566.60 | 1 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity towards MLL fusion protein transformed cells.
- Binds to menin with a Kd of 6.5 nM.
- Leads to strong down-regulation of Hoxa9 and Meis1 gene expression.
- Reduces tumor volume in mice xenografts.
- Improved exposure and Cmax in blood plasma.
- Low clearance and a half-life of about 1.6 hours.
- High oral bioavailability (~50%).
- Soluble in DMSO.
- Soluble in various in vivo protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline.