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A naturally occurring sphingolipid; levels are elevated in the prefrontal cortex and cerebellum in a rat model of STZ-induced diabetes, as well as in the liver in mouse models of Niemann-Pick type C1 disease; plasma are decreased in patients with prostate cancer; has been used in model membranes with POPC and cholesterol in the study of lipid raft dynamics and membrane organization
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C14 ceramide (N-myristoyl-D-sphingosine) is a research-grade sphingolipid provided in ester form for laboratory use. It is intended for in vitro biochemical and cell biology studies of sphingolipid metabolism and signaling. The material is for research use only and is not for human or clinical applications.
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C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
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C18:1-ceramide is a naturally occurring ceramide subspecies used as a biochemical standard and research reagent in studies of lipid metabolism and metabolic disease, including type 2 diabetes. Supplied as solids and as a 10 mM solution in DMSO, it is intended for research use only.
Ceramide subspecies involved in lipid signaling and metabolism.
Used in studies of insulin resistance and type 2 diabetes.
Available as solid quantities and as a ready-to-use DMSO solution.
High purity (≈99.9%), suitable for analytical and biological assays.
Molecular formula C36H69NO3; molecular weight 563.94 g/mol.
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A sphingolipid; levels are increased by PPMP or MAPP in isolated human neutrophils and are correlated with an increase in apoptosis; accumulates in the lungs of patients with cystic fibrosis compared with the lungs of patients with pulmonary hypertension; plasma levels are increased in patients with acute coronary syndrome, and an increased plasma ratio of C16 to C24:0 ceramide is associated with major adverse cardiac events; levels are increased in tumor tissue from patients with breast cancer and is associated with metastatic cancer
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C2 Ceramide is a short-chain synthetic ceramide used as a research reagent and lipid signaling modulator. It acts as an activator of protein phosphatases and is commonly employed in studies of apoptosis, membrane biology, and cell-signaling pathways. Supplied as a solid for laboratory research use only.
Short-chain ceramide used in biochemical and cell-signaling research.
Activates protein phosphatases PP1 and PP2A, useful for phosphatase-related studies.
High purity (99.85%) suitable for research applications.
Soluble in ethanol and DMSO with ultrasonic warming as needed.
Available in small research-scale quantities for laboratory experiments.
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