Sphingolipids
Medchemexpress LLC Sphingomyelin | 85187-10-6 | ≥99.0% | 493.6 g/mol | 25 MG
Sphingomyelin is a eukaryotic sphingolipid that is a major constituent of cell membranes and is particularly abundant in the myelin sheath that surrounds neuronal axons. It plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann-Pick disease.
- Endogenous metabolite
- Plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction.
- Metabolism is associated with various central nervous system diseases and Niemann-Pick disease.
Cayman Chemical C8 Ceramide-1-phosphate (d18:1/8:0) (ammonium salt), Purity: ≥90%, CAS: 474943-70-9, 1 mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Sigma Aldrich Fine Chemicals Biosciences Sphingomyelin chicken500MG
Sphingomyelin (SM) is a principal sphingolipid in mammalian cell membranes. Its biological functions have been studied.
Sigma Aldrich Fine Chemicals Biosciences Ceramide phosphorylethanol5MG
Ceramide phosphorylethanolamine is a phosphosphingolipid. It maintains the structural framework of the plasma membrane aids in the formation and functioning of plasma membrane lipid rafts cell signaling and transduction events. Ceramide phosphorylethanolamine modulates various cellular processes like growth differentiation apoptosis and angiogenesis.
Cayman Chemical C20 Ceramide (d18:1/20:0), Purity: ≥98%, CAS: 7344-02-7, 1 mg
A natural 20:0 ceramide that is abundant in the brain; synthesized de novo by ceramide synthases 1 and 2
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 25 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Avanti Polar Lipids C18:0-d7 GD3 Ceramide (d18:1/18:0-d7), synthetic, 100ug
GD3 ceramide is the main ganglioside within human breast milk. GD3 Ceramides are critical for apoptosis and present in high quantities in various tumor species. This GD2 Ceramide is the deuterated version, which will enable the easier study of structure, dynamics, and function of cell membranes.
Cayman Chemical C6 NBD dihydro Ceramide (d18:0/6:0), Purity: ≥98%, CAS: 114301-97-2, 1 mg
Structurally identical to C6 NBD ceramide, but contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Cayman Chemical C20 Ceramide (d18:1/20:0), Purity: ≥98%, CAS: 7344-02-7, 10 mg
A natural 20:0 ceramide that is abundant in the brain; synthesized de novo by ceramide synthases 1 and 2
Cayman Chemical C12 NBD Ceramide (d18:1/12:0), Purity: ≥98%, CAS: 202850-01-9, 10 mg
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Cayman Chemical C12 NBD Ceramide (d18:1/12:0), Purity: ≥98%, CAS: 202850-01-9, 1 mg
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Cayman Chemical C16 Ceramide (d18:1/16:0), Purity: ≥98%, CAS: 24696-26-2, 1 mg
A sphingolipid; levels are increased by PPMP or MAPP in isolated human neutrophils and are correlated with an increase in apoptosis; accumulates in the lungs of patients with cystic fibrosis compared with the lungs of patients with pulmonary hypertension; plasma levels are increased in patients with acute coronary syndrome, and an increased plasma ratio of C16 to C24:0 ceramide is associated with major adverse cardiac events; levels are increased in tumor tissue from patients with breast cancer and is associated with metastatic cancer
Cayman Chemical C16 Sphingomyelin (d18:1/16:0), Purity: ≥98%, CAS: 6254-89-3, 1 mg
A naturally occurring sphingolipid; levels are elevated in the prefrontal cortex and cerebellum in a rat model of STZ-induced diabetes, as well as in the liver in mouse models of Niemann-Pick type C1 disease; plasma are decreased in patients with prostate cancer; has been used in model membranes with POPC and cholesterol in the study of lipid raft dynamics and membrane organization