Purine nucleosides
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 1 ML
2'-Deoxyadenosine monohydrate is an adenine nucleoside used in research that demonstrates various biological activities including the inhibition of glucose-stimulated insulin release and islet cAMP accumulation. It also activates caspase-3, promotes apoptosis, inhibits SAHH activity, and has an anticancer effect on colon cancer by inhibiting cell growth.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3 and promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | MFCD00149364 | >99.8% | 269.26 | 100 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation, activates caspase-3, and promotes apoptosis. Additionally, it inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) and the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer. It is for research use only and not sold to patients.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3.
- Promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 5 MG
3′-Deoxyguanosine is a derivative of Guanosine. It interacts with human purine nucleoside phosphorylase through hydrogen bonding with residues like Glu201 and Asn243. This compound shows moderate displacement activity for [3H]-guanosine in rat meninges and is useful for studying the mechanism of guanosine receptors and purine metabolism.
- Derivative of Guanosine.
- Interacts with human purine nucleoside phosphorylase via hydrogen bonding.
- Exhibits moderate displacement activity for [3H]-guanosine in rat meninges.
- Useful for studying guanosine receptor mechanisms and purine metabolism.
- For research use only.
Medchemexpress LLC Adenosine, 5'-deoxy- | 4754-39-6 | 99.9% | 251.246 | 25 MG
5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. It shows anti-orthopoxvirus activity.
- Oxidized nucleoside.
- Shows anti-orthopoxvirus activity.
Alkali Scientific 2' Deoxyguanosine monohydrate, 5 Grams
2'-Deoxyguanosine Monohydrate is a nucleoside involved in DNA replication and repair processes. It is a critical component of nucleic acids, particularly in the synthesis of the DNA molecule where it pairs with cytosine. This reagent is commonly used in molecular biology and biochemistry applications, including DNA synthesis, sequencing, and polymerase chain reactions (PCR). The 5-gram quantity is ideal for labs performing high-throughput DNA synthesis, sequencing, and various genetic studies. It is an essential component for laboratories working with nucleic acids, particularly in the synthesis of oligonucleotides and the study of nucleotide incorporation into DNA sequences.
Alkali Scientific 2' Deoxyguanosine monohydrate, 1 Kilogram
2' Deoxyguanosine Monohydrate is a high-purity nucleoside used extensively in molecular biology and biochemical research. This compound is vital in DNA synthesis and research, serving as a key component in nucleotide analog studies. The monohydrate form ensures high solubility and stability in aqueous solutions, making it ideal for cell culture and in vitro experiments. It is widely used in the synthesis of nucleic acids, DNA sequencing, and other genetic research applications. This 1-kilogram package provides ample material for large-scale experiments and research studies, offering researchers a cost-effective and reliable source for high-purity deoxyguanosine.
Biotium MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker)(VU-4H5), CF740 conjugate, 0.1mg/mL
MAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU4H5 is APDTR as established with 'epitope fingerprinting'. VU-4H5 preferentially binds to under-glycosylated 'tumor' MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Medchemexpress LLC Guanosine, 8-bromo-2'-deoxy- | 13389-03-2 | ≥98.0% | 346.14 | 1 ML
8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and early biomarker of oxidative tissue damage. It serves as an immunogen for mAb8B3, detecting DNA modifications. Elevated urinary levels occur in inflammatory disease models. Used in studies for inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation.
- Inflammation-related DNA halogenated adduct.
- Early biomarker of inflammation-induced oxidative tissue damage.
- Immunogen for mAb8B3 monoclonal antibody.
- Urinary levels increase in inflammatory disease models.
- Applications in inflammatory diseases, diabetes, hepatocellular carcinoma, UV-B induced skin inflammation.
- High, specific cross-reactivity with mAb8B3 in competitive indirect ELISA.
Medchemexpress LLC N6-Ethyladenosine | 14357-08-5 | 99.9% | 295.29 | 1 ML
N6-Ethyladenosine is an adenosine derivative that functions as an Adenosine receptor agonist, with Ki values of 4.9 nM and 4.7 nM for hA1AR and hA3AR, respectively. It exhibits higher selectivity for hA1AR and hA3AR compared to hA2AR (Ki, 8900±770 nM).
- Adenosine receptor agonist
- High selectivity for hA1AR and hA3AR over hA2AR
- Available in solid and solution forms
- Available for bulk inquiry
- Supported by research publications
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 10 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release and glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis, and inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). This compound can inhibit the growth of various cells and has an anticancer effect on colon cancer.
- Inhibits glucose-stimulated insulin release
- Activates caspase-3 and promotes apoptosis
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity
- Inhibits the growth of various cells
- Demonstrates an anticancer effect on colon cancer
- For research use only