Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Guanosine 5'-triphosphate-5'-adenosine triammonium | 00-00-0 | 100.0% | 823.50 | C20H36N13O17P3 | 5 MG
Guanosine 5'-triphosphate-5'-adenosine triammonium is a 5′ cap analog and fluorescent substrate analog used in vitro for RNA synthesis and enzymatic assays. It is supplied as a high-purity triammonium salt in small-mass vials for research applications.
- Cap analog for in vitro RNA synthesis.
- Fluorescent substrate analog suitable for enzymatic assays.
- High purity for reproducible experimental results.
- Available in multiple small sizes, including 5 mg vials.
- Molecular weight provided for accurate molarity calculations.
- Triammonium salt form enhances aqueous solubility.
Sigma Aldrich Fine Chemicals Biosciences Guanosine 5′-triphosphate sodium salt hydrate | 36051-31-7 | MFCD00077781 | 25mg
Guanosine 5′-triphosphate sodium salt hydrate | 36051-31-7 | MFCD00077781 | 25mg
AdipoGen Guanosine 5-triphosphate Na
Chemical. CAS 36051-31-7. Formula C10H16N5O14P3 . xNa. Molecular Weight 523.18 free acid basis. Guanosine 5-triphosphate GTP trisodium salt activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. It also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA F-met-tRNA to the ribosome. It is also involved in polypeptide chain elongation.
Apexbio Technology LLC 8-Azido-ATP(Synonyms: 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine triphosphate), 10ul (100 mM).
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Apexbio Technology LLC Adenosine 5'-monophosphate disodium 4578-31-8 1g
Adenosine 5p-monophosphate disodium is a purine nucleotide derivative composed of adenosine linked to a phosphate group presented as the disodium salt It functions as an intermediate in cellular metabolism contributing directly to ATP biosynthesis and degradation pathways and serves as a biochemical precursor and degradation product in energy exchange reactions Adenosine 5p-monophosphate disodium exerts its biological activity as part of pathways regulating gene expression protein synthesis modulation and intracellular signal transduction In biomedical research it is utilized to investigate mechanisms underlying energy metabolism nucleic acid metabolism and cellular homeostasis Based on these characteristics Adenosine 5p-monophosphate disodium holds research potential in studies of metabolic function ATP-dependent signaling pathways and related disease models
Medchemexpress LLC Cytarabine triphosph 10mg | 1179343-17-9 | 549.10 | C9H13N3Na3O14P3 | 10 MG
Cytarabine triphosphate trisodium is the trisodium salt of the active intracellular metabolite of cytarabine, provided as an aqueous solution for biochemical and cell biology research. It acts as a competitive inhibitor of DNA synthesis and is used to study nucleoside metabolism and antimetabolite mechanisms.
- Active intracellular metabolite of cytarabine (Ara-CTP).
- Competitive inhibitor of DNA synthesis.
- Supplied as an aqueous solution at 100 mM; common pack sizes include 5 mg, 10 mg, 25 mg, and 50 mg.
- Purity: 96.78%.
- Appearance: colorless to light yellow liquid.
- Salt form: trisodium; molecular weight 549.10; formula C9H13N3Na3O14P3.
- Storage: store at -20°C for long-term; stock solutions at -80°C (up to 6 months) or -20°C (1 month).
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5-triphosphate p25MG
Adenosine 5AE-triphosphate 2AE 3AE dialdehyde is a derivative of dialdehyde.
Medchemexpress LLC Desethyl chloroquine diphosphate | 247912-76-1 | MFCD28138115 | 99.7% | 487.81 | C16H28ClN3O8P2 | 5 MG
Desethyl chloroquine diphosphate is the diphosphate salt of desethyl chloroquine supplied as a research reagent and analytical standard. It is provided as a high-purity solid intended for biochemical, pharmacological, and analytical applications, with documentation including a data sheet and safety data sheet.
- High purity suitable for analytical work (reported 99.7%).
- Diphosphate salt form for improved solubility and stability.
- Molecular weight 487.81 and formula C16H28ClN3O8P2 for accurate calculations.
- Available in small milligram pack sizes for reference and method development.
- Supplied with datasheet and SDS for handling and compliance.
![Research Products International Corp ATP [Adenosine-5'-triphosphate, disodium salt trihydrate], 1 Gram](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-A30030-1.0.JPG-250.jpg)
Research Products International Corp ATP [Adenosine-5'-triphosphate, disodium salt trihydrate], 1 Gram
An essential nucleotide triphosphate with a variety of roles in energy metabolism, signal transduction and nucleic acid metabolism.