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Two-carbon nitrogen ring bases (adenine and guanine) covalently linked to a sugar (ribose or deoxyribose) and one to three phosphate groups; can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
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Motesanib diphosphate is a small-molecule, ATP-competitive inhibitor of vascular endothelial growth factor receptors VEGFR1, VEGFR2, and VEGFR3 that also inhibits Kit. The diphosphate salt is supplied for research and analytical applications.
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Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo. purity: 95%
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Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a nucleotide sugar that donates glucuronic acid in enzymatic conjugation reactions. Supplied as a high-purity solid, it is used as a cofactor in in vitro assays of glucuronyltransferases and in studies of UDP-dependent metabolism. The compound has CAS 2616-64-0 and a molecular weight of 580.29 g/mol.
High purity (98.0%) solid suitable for biochemical assays.
Serves as a glucuronic acid donor for glucuronyltransferases.
Used in enzymatic and metabolic pathway studies.
Available in small research quantities for laboratory use.
Molecular formula C15H22N2O18P2 and molecular weight 580.29 g/mol.
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Desethyl chloroquine diphosphate is the diphosphate salt of desethyl chloroquine supplied as a research reagent and analytical standard. It is provided as a high-purity solid intended for biochemical, pharmacological, and analytical applications, with documentation including a data sheet and safety data sheet.
High purity suitable for analytical work (reported 99.7%).
Diphosphate salt form for improved solubility and stability.
Molecular weight 487.81 and formula C16H28ClN3O8P2 for accurate calculations.
Available in small milligram pack sizes for reference and method development.
Supplied with datasheet and SDS for handling and compliance.
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3AE-phosphoadenosine 5AE-phosphate (PAP) a 3AE-phosphorylated nucleotide is found in almost all organisms and is obtained as a by-product of sulfur and lipid metabolism.
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Exists as a 557AkDa hexadecamer composed of eight heavy chains each with a molecular weight of approximately 56AkDa and eight light chains of molecular weight 14AkDa. Each molecule contains one magnesium ion. pH optimum ~7.9. KM for CO2 ~0.45 mM. Ribulose diphosphate becomes inhibitory at concentrations exceeding 0.7 mM. Orthophosphate and ammonium sulfate are competitive inhibitors. 3-Phosphoglycerate is a noncompetitive inhibitor.
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Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes.
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MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
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Motesanib diphosphate is the diphosphate salt of a small-molecule ATP-competitive inhibitor of vascular endothelial growth factor receptors (VEGFR1/2/3). It is supplied as a research-grade analytical standard for biochemical assays, pathway studies, and method development. The compound should be stored sealed and protected from moisture; in solvent, stability is -80°C for up to six months and -20°C for up to one month.
High purity (~99.9%).
Potent VEGFR1/2/3 inhibition with IC50s 2-6 nM.
Molecular formula C22H29N5O9P2, molecular weight 569.44 g/mol.
Suitable for biochemical assays and analytical method development.
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Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB) Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication with EC50 values of 0 5-1 4 M in different EV71 strains[1 [2
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Adenosine antagonist-1 is a small-molecule adenosine A3 receptor (A3R) antagonist reported to have anti-inflammatory activity for in vitro and preclinical research. The compound is supplied as a white to off-white solid with molecular formula C18H13N7S and molecular weight 359.41 g/mol. Typical purity is 99.79% and the material is provided in milligram-scale quantities for laboratory studies.
Acts as an adenosine A3 receptor antagonist with anti-inflammatory activity.
High chemical purity (99.79%) suitable for research applications.
Molecular formula C18H13N7S; molecular weight 359.41 g/mol.
Available in milligram-scale quantities for in vitro and preclinical studies.
Supplied as a white to off-white solid for easier handling and storage.
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