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Two-carbon nitrogen ring bases (adenine and guanine) covalently linked to a sugar (ribose or deoxyribose) and one to three phosphate groups; can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
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NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its triphosphate form. It acts as a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA.
May directly target the viral polymerase and act as a nonobligate chain terminator
Plays a significant role in inhibiting early negative-strand RNA synthesis
Interferes with correct replicase complex formation through chain termination or mutagenesis
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Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. It exhibits dual affinity toward A1/A2A ARs, with a higher affinity for the A1- than the A2AAR. The compound has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR.
Potent AR inhibitor
Dual affinity toward A1/A2A ARs
Higher affinity for A1AR (52.2 nM Ki)
Lower affinity for A2AAR (167 nM Ki)
Formula: C17H20BrN5O2
Appearance: Solid
Color: White to off-white
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Adenosine monophosphate-13C10,15N5 dilithium is an isotope-labeled compound primarily utilized as an internal standard for quantitative analysis of Adenosine monophosphate. This compound acts as an adenosine A1 receptor agonist and demonstrates significant antiviral activity against HSV-1 and HSV-2. It plays a crucial role as a cellular metabolite, regulating energy homeostasis and signal transduction.
Isotope-labeled compound for quantitative analysis
Acts as an adenosine A1 receptor agonist
Shows significant antiviral activity against HSV-1 and HSV-2
Key cellular metabolite in energy homeostasis and signal transduction
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Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate with inosine as the nucleobase. It participates in intracellular energy metabolism and signal transduction processes.
Purine ribonucleoside 5'-diphosphate
Contains inosine as the nucleobase
Participates in intracellular energy metabolism
Involved in signal transduction processes
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Adenosine Kinase Inhibitor (hydrate) is a small-molecule inhibitor targeting adenosine kinase It is designed to inhibit adenosine kinase thereby regulating intracellular adenosine metabolism Adenosine Kinase Inhibitor (hydrate) exerts its biological activity primarily through selective enzyme inhibition In cell-free conditions Adenosine Kinase Inhibitor (hydrate) demonstrates potent inhibitory activity with an IC50 value of approximately 1 7 nM Based on these pharmacological properties Adenosine Kinase Inhibitor (hydrate) holds research potential in investigating pain perception mechanisms and inflammation modulation through adenosine signaling pathways
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Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a nucleotide sugar that donates glucuronic acid in enzymatic conjugation reactions. Supplied as a high-purity solid, it is used as a cofactor in in vitro assays of glucuronyltransferases and in studies of UDP-dependent metabolism. The compound has CAS 2616-64-0 and a molecular weight of 580.29 g/mol.
High purity (98.0%) solid suitable for biochemical assays.
Serves as a glucuronic acid donor for glucuronyltransferases.
Used in enzymatic and metabolic pathway studies.
Available in small research quantities for laboratory use.
Molecular formula C15H22N2O18P2 and molecular weight 580.29 g/mol.
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Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available displaying a marked activity against gametocytes of all species of human malaria
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Cytarabine triphosphate trisodium is the active intracellular triphosphate metabolite of cytarabine that competitively inhibits DNA synthesis. Supplied as an aqueous solution, it is intended for biochemical and cellular research requiring the active nucleotide form.
Active triphosphate metabolite of cytarabine.
Competitive inhibitor of DNA synthesis.
Supplied as an aqueous liquid for direct use or dilution.
Packaged as 50 mg (100 mM, 1 mL) solution.
Purity about 96.8% and recommended storage at -20°C.
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Adenosine monophosphate-15N5 dilithium is the 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist and has significant antiviral activity against HSV-1 and HSV-2. It is a key cellular metabolite regulating energy homeostasis and signal transduction. This compound can be used as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Used as a tracer
Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Stable heavy isotopes incorporated into drug molecules as tracers
Potential to affect the pharmacokinetic and metabolic profiles of drugs
Product of various enzymatic reactions, many of which are dysregulated during disease conditions
Shipping: Room temperature in continental US; may vary elsewhere
Storage: Solution, -20°C, 2 years
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AZT triphosphate tetraammonium is the tetraammonium salt of the active triphosphate metabolite of zidovudine (AZT). Supplied as an off-white to light yellow solid, it is used as a biochemical reagent and reference standard in studies of viral polymerase activity and nucleotide metabolism.
Active triphosphate metabolite of zidovudine with antiretroviral activity.
Supplied as a stable solid suitable for biochemical assays and standards.
High purity (99.25%) to support analytical and research applications.
Store sealed at -20°C; in solution store at -80°C for long-term stability.
Available in small quantities (for example, 1 mg) and larger sizes for research use.
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