Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC 2-Amino-ATP(Synonyms: 2-NH2-ATP, 2-Aminoadenosine triphosphate, 2-Amino-adenosine-5'-triphosphate, 2-Amino-ATP (free acid)), 100ul (100 mM).
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism
Medchemexpress LLC Cidofovir diphosphate tri(triethylamine) | 00-00-0 | 99.9% | 742.72 g/mol | C26H61N6O12P3 | 5 MG
Cidofovir diphosphate tri(triethylamine) is the triethylamine salt of cidofovir diphosphate, an active intracellular metabolite and selective inhibitor of viral DNA polymerases. It is provided as a high-purity biochemical reagent intended for in vitro and biochemical research applications.
Medchemexpress LLC Adenosine 5'-triphosphate | 56-65-5 | 95.7% | 507.18 g/mol | C10H16N5O13P3 | 10 MG
Adenosine 5'-triphosphate (ATP) standard supplied as a 10 mg solid for analytical and research use. It is intended as a calibration and reference material for quantitation of ATP in biochemical assays, metabolic studies, and signaling research.
- Analytical reference standard for ATP quantitation.
- High purity: 95.7%.
- White to off-white solid suitable for dissolution in aqueous buffers.
- Useful for assay calibration, method development, and quality control.
- Includes CAS number 56-65-5 for clear substance identification.
Sigma Aldrich Fine Chemicals Biosciences Adenosine Quantification A
Adenosine is a purine nucleoside base which is the precursor of adenosine triphosphate or ATP and is utilized thoroughly throughout the entire body in general metabolism. Extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. Its effects on tissue protection and repair fall into four categories increasing the ratio of oxygen supply to demand protecting against ischaemic damage by cell conditioning triggering anti-inflammatory responses and the promotion of angiogenesis.
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | >98.0% | 569.44 | C22H29N5O9P2 | 50 MG
Motesanib diphosphate is the diphosphate salt of motesanib, an ATP-competitive small-molecule inhibitor of VEGF receptors used as a research reagent for kinase and signaling studies.
- ATP-competitive inhibitor of VEGFR1/2/3 with low-nanomolar potency.
- Diphosphate salt form improves aqueous solubility for in vitro applications.
- Molecular weight 569.44; formula C22H29N5O9P2.
- High solubility in DMSO (≥110 mg/mL) and moderate solubility in water (≈5 mg/mL with warming).
- Intended for research and analytical use; not for human or clinical use.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 98.2% | 559.32 g/mol | C15H23N5O14P2 | 5 MG
Adenosine 5'-diphosphoribose is an endogenous nucleotide (ADP ribose) consisting of an adenine base linked to a ribose and two phosphate groups. Supplied as a research-grade solid, it is used in biochemical and cellular assays to investigate ADP-ribosylation signaling, DNA damage response pathways, and calcium-permeable TRPM2 channel activation. The material is provided in assay-friendly quantities with supporting documentation for safe handling.
Medchemexpress LLC Kinetin triphosphate tetrasodium | 00-00-0 | 99.9% | C15H16N5Na4O14P3 | 10MG
Kinetin triphosphate tetrasodium is an ATP analogue used in biochemical and kinase research, including investigations of mitochondrial quality control pathways. It is supplied as a tetrasodium salt in small milligram quantities and includes documentation for experimental use and handling.
- ATP analogue for kinase and enzymology assays.
- High purity (99.92%) suitable for sensitive biochemical studies.
- Soluble in water with recommended reconstitution guidance (100 mM preparations).
- Provided in small research quantities for experimental flexibility.
- Documentation includes datasheet, certificate of analysis, and safety data sheet.