Drug Standards
Apexbio Technology LLC AUY922 (NVP-AUY922) 747412-49-3 10mg
AUY922 (NVP-AUY922 CAS 747412-49-3) is a synthetic small molecule inhibitor belonging to the resorcinylic isoxazole amide class that selectively targets heat shock protein 90 (HSP90) AUY922 specifically interacts with the ATP-binding site of the HSP90 N-terminal domain disrupting its chaperone-dependent stabilization of client proteins involved in cell proliferation and survival It demonstrates antiproliferative activity against human gastric cancer cells with reported GI50 values ranging approximately from 2 to 40 nmol/L promoting the proteasomal degradation of receptor tyrosine kinases and other relevant client proteins This compound is widely used in preclinical research settings investigating HSP90-dependent signaling pathways in cancer
Apexbio Technology LLC Ruxolitinib phosphate 1092939-17-7 100mg
Ruxolitinib phosphate (CAS 1092939-17-7) is an orally available small molecule inhibitor selective for Janus-associated kinases (JAKs) particularly potent against JAK1 and JAK2 with IC50 values of approximately 3 nM and 5 nM respectively It displays relatively lower inhibitory activity toward JAK3 (IC50 332 nM) By blocking JAK-mediated signal transduction Ruxolitinib phosphate disrupts downstream cytokine signaling pathways involved in inflammatory and proliferative responses This compound is widely utilized in biomedical research focusing on inflammatory disorders particularly rheumatoid arthritis
Medchemexpress LLC Lenalidomide 4'-PEG2-amine dihydrochloride | 2624336-88-3 | 99.0% | 463.36 g/mol | C19H28Cl2N4O5 | 10 MG
Lenalidomide 4'-PEG2-amine dihydrochloride is a lenalidomide-derived Cereblon (CRBN) ligand functionalized with a PEG2-amine linker, supplied as the dihydrochloride salt for use in targeted protein degradation research. It is intended for conjugation to target ligands to construct PROTACs and other E3 ligase-recruiting molecules.
- Lenalidomide-derived CRBN ligand functionalized with a PEG2-amine linker.
- Designed for conjugation to target-binding ligands to enable PROTAC synthesis.
- Dihydrochloride salt for improved handling in research workflows.
- Molecular weight 463.36 g/mol and formula C19H28Cl2N4O5.
- High purity (98.96%), suitable for research applications.
- Available in mg-scale packages for lab-scale synthesis and screening.
Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice
Cayman Chemical EthacrynIc AcId 1g
A loop diuretic with anticancer activity; inhibits the NKCC cotransporter in duck erythrocytes (IC50 = 0.18 mM); inhibits ATP-dependent chloride uptake in rat renal plasma membrane vesicles at 0.3 mM; inhibits GSTP1-1 and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively); inhibits Wnt/β-catenin signaling in a cell-based reporter assay; cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively); increases tumor growth reduction induced by afatinib or neratinib in a 4T1 murine breast cancer model at 250 μg per day
Medchemexpress LLC Methylprednisolone | 83-43-2 | >99.8% | 2 G
Methylprednisolone | 83-43-2 | >99.8% | 2 G
Sigma Aldrich Fine Chemicals Biosciences Aloin United States Pharmacopeia (USP) Reference Standard | 1415-73-2 | MFCD00151160 | 25MG
Aloin United States Pharmacopeia (USP) Reference Standard | Mol Wt: 418.39 | 1415-73-2 | MFCD00151160 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Sodium acetate trihydrate | 6131-90-4 | MFCD00071557 | 1 g
Sodium acetate trihydrate | Mol Wt: 136.08 | 6131-90-4 | MFCD00071557 | 1 g
Medchemexpress LLC Tavarborol impurity 16 | 1839665-96-1 | MFCD32689443 | 247.06 | 5 G
Tavarborol impurity 16 is an impurity of Tavaborol. It is used as a drug intermediate.
- Impurity of Tavaborol
- Suitable for drug intermediate research