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Filtered Search Results
Medchemexpress LLC Gozanertinib | 1226549-49-0 | 98.4% | 100 MG
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Gozanertinib, also known as DBPR112, is an orally active furanopyrimidine-based EGFR inhibitor. It functions by occupying the ATP-binding site and demonstrates significant antitumor efficacy.
- Inhibits EGFRWT with an IC50 of 15 nM
- Inhibits EGFRL858R/T790M with an IC50 of 48 nM
- Induces dose-dependent reduction of phosphorylated EGFR in H1975 cells
- Demonstrates inhibitory activity against HCC827 (CC50=25 nM), H1975 (CC50=620 nM), and A431 (CC50=1.02 μM) cell lines
- Reduces tumor growth in HCC827 tumor models
- Shows antitumor effect in H1975 tumor models
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Medchemexpress LLC SMYD3-IN-1 | 2095160-79-3 | 98.0% | 100 MG
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SMYD3-IN-1 is an irreversible and selective inhibitor of SMYD3, with an IC50 of 11.7 nM. It is intended for research use only. This compound has a molecular weight of 507.02, a chemical formula of C28H31ClN4O3, and appears as an off-white to pink solid. It exhibits solubility of 100 mg/mL in DMSO.
- Selective SMYD3 inhibitor with an IC50 of 11.7 nM
- Molecular weight of 507.02
- Chemical formula: C28H31ClN4O3
- Appears as an off-white to pink solid
- Solubility of 100 mg/mL in DMSO
- GI50 of 1.04 μM in HepG2 cells for inhibition of SMYD3 in anchorage-independent colony formation
- GI50 of 17.69 μM in HepG2 cells for inhibition of cell proliferation
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eMolecules 1627924-17-7 | 3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid | ChemScene | MFCD29918654 | 322.102 | C9H11IN2O3 | 98.000 | OC(=O)c1cn(nc1I)C1CCCCO1 | 100mg | 572167050
3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid | ChemScene | 1627924-17-7 | MFCD29918654 | 322.102 | C9H11IN2O3 | 98.000 | OC(=O)c1cn(nc1I)C1CCCCO1 | 100mg | 572167050
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Medchemexpress LLC SR-4835 | 2387704-62-1 | 99.5% | 50 MG
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SR-4835 is a potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). It acts synergistically with DNA-damaging chemotherapy and PARP inhibitors, leading to cell death in triple-negative breast cancer (TNBC) cells.
- Potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13
- Inhibits CDK12 (IC50=99 nM, Kd=98 nM)
- Inhibits CDK13 (Kd=4.9 nM)
- Acts synergistically with DNA-damaging chemotherapy and PARP inhibitors
- Leads to cell death in triple-negative breast cancer (TNBC) cells
- Suppresses ATM and RAD51 protein levels
- Triggers intronic polyadenylation site cleavage
- Suppresses expression of core DNA damage response proteins
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Nu Chek Prep Inc GLC Reference Standard 710 | 100mg
GLC Reference Standard 710 | 100mg
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Sigma Aldrich Fine Chemicals Biosciences 1,4-Dioxane solution NMR reference standard, 40% in benzene-d6 (99.6 atom % D) | 123-91-1 | MFCD00006571 | 8IN
1,4-Dioxane solution NMR reference standard, 40% in benzene-d6 (99.6 atom % D) | Purity: 99% (CP) | Mol Wt: 88.11 | 123-91-1 | MFCD00006571 | 8IN
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Chem-Impex International, Inc. Albumin standard powder (heat shock isolation, from bovine blood) | 9048-46-8 | MFCD00130384 | 25G
Albumin standard powder (heat shock isolation, from bovine blood), 9048-46-8, MFCD00130384, 25G
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eMolecules 856689-51-5 | Medchem Express | ONO-0300302 | 5mg | 719835699 | HY-115450 | 477.601 | C29H35NO5
Medchem Express | ONO-0300302 | 5mg | 719835699 | HY-115450 | 856689-51-5 | 477.601 | C29H35NO5
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eMolecules 197792-52-2 | tert-Butyl 2-(3-bromophenyl)acetate | Ambeed | MFCD19026476 | 271.154 | C12H15BrO2 | 95.000 | CC(C)(C)OC(=O)Cc1cccc(Br)c1 | 100mg | 592282561
tert-Butyl 2-(3-bromophenyl)acetate | Ambeed | 197792-52-2 | MFCD19026476 | 271.154 | C12H15BrO2 | 95.000 | CC(C)(C)OC(=O)Cc1cccc(Br)c1 | 100mg | 592282561
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Medchemexpress LLC Florbetapir (Standard) (AV-45 (Standard)) | 938435-69-9 | 99.5% | 1 MG
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Florbetapir (Standard) (AV-45 (Standard)) is an analytical standard of Flobetapir (HY-129650) intended for research and analytical applications. Flobetapir is a well-tolerated imaging agent that synthesizes Florbetapir (18F), a PET scanning radiopharmaceutical compound.
- Used for research and analytical applications
- Commonly used in qualitative, quantitative and methodological research experiments
- Suitable for HPLC, GC and MS applications
- Molecular weight is 360.42
- Appears as a solid, light brown to yellow in color
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eMolecules 77497-96-2 | (3S)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid benzyl ester | J&W PharmLab LLC | MFCD03419265 | 267.328 | C17H17NO2 | 96.000 | O=C(OCc1ccccc1)[C@@H]1Cc2ccccc2CN1 | 500mg | 665625566
(3S)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid benzyl ester | J&W PharmLab LLC | 77497-96-2 | MFCD03419265 | 267.328 | C17H17NO2 | 96.000 | O=C(OCc1ccccc1)[C@@H]1Cc2ccccc2CN1 | 500mg | 665625566
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Sigma Aldrich Fine Chemicals Biosciences Sucrose British Pharmacopoeia (BP) Reference Standard | 57-50-1 | MFCD00006626 |
Sucrose British Pharmacopoeia (BP) Reference Standard | Mol Wt: 342.3 | 57-50-1 | MFCD00006626 |
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Sigma Aldrich Fine Chemicals Biosciences Alpinetin phyproof(R) Reference Substance | 36052-37-6 | MFCD00238532 | 10MG
Alpinetin phyproof(R) Reference Substance | Purity: >=95.0% (HPLC) | Mol Wt: 270.28 | 36052-37-6 | MFCD00238532 | 10MG
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Sigma Aldrich Fine Chemicals Biosciences Metronidazole British Pharmacopoeia (BP) Reference Standard | 443-48-1 | MFCD00009750 |
Metronidazole British Pharmacopoeia (BP) Reference Standard | Mol Wt: 171.15 | 443-48-1 | MFCD00009750 |
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 5744-59-2 | 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid | Ambeed | MFCD00085040 | 140.142 | C6H8N2O2 | 98.000 | Cc1cc(nn1C)C(O)=O | 1g | 490504071
1,5-Dimethyl-1H-pyrazole-3-carboxylic acid | Ambeed | 5744-59-2 | MFCD00085040 | 140.142 | C6H8N2O2 | 98.000 | Cc1cc(nn1C)C(O)=O | 1g | 490504071
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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