Carbon Oxygen Demand Standards
Apexbio Technology LLC Chlorprothixene (hydrochloride) 6469-93-8 10g
Chlorprothixene hydrochloride (CAS 6469-93-8) is a small-molecule antagonist targeting dopamine (D1 D2 D3 D5) and histamine H1 receptors It modulates neurotransmission by blocking these receptors thereby regulating dopaminergic and histaminergic pathways Chlorprothixene hydrochloride exerts its biological activity primarily through receptor antagonism In in vitro studies it demonstrates nanomolar affinity with Ki values of 18 nM (D1) 2 96 nM (D2) 4 56 nM (D3) 9 nM (D5) and 3 75 nM (H1) Additionally it reduces SARS-CoV viral replication (IC50 13 0 18 5 M depending on strain) Based on these pharmacological properties chlorprothixene hydrochloride holds research potential in antipsychotic therapy antiviral investigation and modulation of inflammation in cystic fibrosis models
Apexbio Technology LLC sodium fluoride 10000mg
Sodium fluoride is an inorganic compound widely utilized in biomedical research for its inhibitory action on enzymes involved in cellular metabolism particularly enolase within the glycolytic pathway By inhibiting glycolytic activity sodium fluoride disrupts ATP production making it a valuable tool for assessing metabolic processes in vitro It is commonly employed to prevent glycolysis in blood samples for biochemical assays and in studies investigating metabolic regulation cellular energetics and mechanisms of fluoride toxicity Sodium fluoride s modulation of metabolic enzymes supports its use in mechanistic studies of cell physiology and metabolic control
SCP Science COD Control Solution, 10000 ppm O2, 500 mL
AccuSPEC standards and reagents for BOD, COD, and TOC are prepared following guidelines from "Standard Methods for the Examination of Water and Wastewater", 20th Edition. They are available in custom sizes and custom concentrations in order to reduce cost and maximize productivity.
Cambridge Isotope Laboratories Fortified Cod Liver Oil Reference Material 10 g
Fortified Cod Liver Oil Reference Material 10 g
Apexbio Technology LLC L-Phenylephrine 59-42-7 10g
L-Phenylephrine (CAS 59-42-7) is a selective agonist of the adrenergic 1A receptor exhibiting a Ki of 1 4 M with markedly lower affinity for 1B (Ki 23 9 M) and 1C (Ki 47 8 M) subtypes In vitro L-Phenylephrine has been shown to reduce apoptosis in neonatal rat cardiomyocytes following hypoxia and serum deprivation and to stimulate proliferation in neural progenitor cells It also increases the cross-sectional area and modulates gene expression in rat neonatal cardiomyocytes In vivo local administration in rats induces cutaneous anesthesia through 1-adrenergic receptor activation and clinical data suggest oral administration reduces nasal airway resistance These properties make L-Phenylephrine a valuable tool for studying 1A-adrenergic receptor-mediated cellular responses
Apexbio Technology LLC Clofibrate 637-07-0 10g
Clofibrate (CAS 637-07-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor alpha (PPAR-alpha) It is designed to activate PPAR-alpha thereby regulating lipid and lipoprotein metabolism pathways Clofibrate exerts its biological activity primarily through PPAR-alpha activation leading to enhanced peroxisome proliferation and fatty acid oxidation In both human and mouse models Clofibrate demonstrates agonist activity with EC50 values of 55 M and 500 M respectively Based on these pharmacological properties Clofibrate holds research potential in investigating lipid metabolism triglyceride regulation and the roles of PPAR-alpha signaling in hyperlipidemia and related metabolic disorders
Apexbio Technology LLC Naproxen Sodium 26159-34-2 10g
Naproxen sodium (CAS 26159-34-2) is a non-selective cyclooxygenase (COX) inhibitor that suppresses both COX-1 and COX-2 activity In vitro it exhibits IC50 values of 35 48 mol/L for COX-1 and 64 62 mol/L for COX-2 Naproxen sodium influences satellite cell biology by affecting proliferation fusion and differentiation particularly when both COX-1 and COX-2 are inhibited In HCA-7 colon cancer cells naproxen reduces cell viability with an IC50 of 1 45 0 07 M after 48-hour exposure Clinically repeated dosing in volunteers results in substantial inhibition of COX isoforms while research in menstrual migraine models shows significant reductions in headache parameters
Apexbio Technology LLC Solvent Blue 35 17354-14-2 10g
Solvent Blue 35 (CAS 17354-14-2) is a synthetic lipophilic dye used for selective staining of triglycerides in animal tissue samples It integrates into nonpolar solvents such as alcohols and hydrocarbons to facilitate visualization of neutral lipid components within histological techniques Solvent Blue 35 is applied in laboratory settings for analyzing lipid accumulation distribution and metabolism Based on these properties Solvent Blue 35 holds research potential in the investigation of physiological and pathological lipid storage including fatty liver disease metabolic disorders obesity and related biomedical studies of lipid metabolic pathways
Apexbio Technology LLC Fuchsine base monohydrochloride 632-99-5 10g
Fuchsine base monohydrochloride (632-99-5) is a synthetic dye belonging to the triphenylmethane family It is designed for staining applications to visualize cellular and tissue components in histological and cytological studies Fuchsine base monohydrochloride exerts its biological activity primarily through binding with negatively charged groups particularly carboxyl-rich sites within cell structures Based on these properties Fuchsine base monohydrochloride holds research potential in biomedical cytological and histological applications for the analysis of tissue morphology cellular anatomy and biological process visualization
Apexbio Technology LLC Azido-PEG6-alcohol 86770-69-6 10g
Azido-PEG6-alcohol (CAS 86770-69-6) is a polyethylene glycol-based compound featuring an azide functional group It serves as a versatile building block in bioorthogonal conjugation strategies particularly in click chemistry applications The azide moiety allows it to participate in copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO- or BCN-functionalized compounds These properties enable its use in the synthesis of antibody-drug conjugates (ADCs) and in preparing diverse bioconjugates for biomedical research
Apexbio Technology LLC Betaine hydrochloride 590-46-5 10g
Betaine hydrochloride (CAS 590-46-5) is a quaternary ammonium compound that serves as a methyl group donor in cellular metabolism notably participating in the methionine-homocysteine cycle to modulate homocysteine levels Extracted from natural sources such as wolfberry and Achyranthes this molecule is soluble in water and ethanol facilitating its use in various assay systems Betaine hydrochloride is frequently employed in biomedical research to investigate metabolic regulation methylation processes and osmoregulatory mechanisms The compound should be stored tightly sealed in cool dry conditions to maintain stability for experimental applications
Apexbio Technology LLC (±)-Baclofen 1134-47-0 10g
( )-Baclofen (CAS 1134-47-0) is a selective agonist of the -aminobutyric acid type B (GABAB) receptor a G protein-coupled receptor involved in inhibitory neurotransmission Exhibiting an IC50 of 200 nM ( )-baclofen induces skeletal muscle relaxation and reduces spasticity by activating GABAB-mediated signaling pathways In cellular studies ( )-baclofen inhibits the proliferation of human hepatocellular carcinoma (HCC) cells in a dose-dependent manner induces G0/G1 cell cycle arrest and modulates intracellular cAMP and p21WAF1 expression In vivo it suppresses tumor growth in HCC xenograft models without evident toxicity ( )-Baclofen is thus valuable for investigating GABAB-mediated mechanisms in cancer and neuropharmacology