Acetylides

Aobchem AOBCHEM

5001045709 2-METHYL-4-PHENYL-3-BUTYN-2-OL

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Aobchem AOBCHEM

5001060519 3-BUTYN-1-OL 1-METHANESULFONA

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eMolecules​ 886465-16-3 | 2-CHLORO-5-(TRIFLUOROMETHOXY)BENZIMIDAZOLE | AstaTech | MFCD11111667 | 236.580 | C8H4ClF3N2O | 95.000 | FC(F)(F)Oc1ccc2[nH]c(Cl)nc2c1 | 1g | 533784314

2-CHLORO-5-(TRIFLUOROMETHOXY)BENZIMIDAZOLE | AstaTech | 886465-16-3 | MFCD11111667 | 236.580 | C8H4ClF3N2O | 95.000 | FC(F)(F)Oc1ccc2[nH]c(Cl)nc2c1 | 1g | 533784314

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Medchemexpress LLC Propargyl-PEG1-SS-PEG1-t-butyl ester | 1807518-78-0 | MFCD28505559 | >98.0% | 320.47 g/mol | C14H24O4S2 | 10 MG

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Propargyl-PEG1-SS-PEG1-t-butyl ester is a cleavable PEG-based linker containing terminal propargyl (alkyne) groups and a disulfide bond. It is used in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and as a click-chemistry handle for azide-alkyne cycloaddition.

• Cleavable disulfide linkage allows intracellular reduction and payload release.
• Terminal propargyl groups enable copper-catalyzed and strain-promoted click reactions.
• High purity (>98.0%) suitable for synthetic chemistry applications.
• Molecular weight 320.47 g/mol and formula C14H24O4S2.
• Available in small research quantities (5 mg, 10 mg, 25 mg) for lab-scale synthesis.

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eMolecules​ 106-96-7 | Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 250g | 716994726

Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical | 106-96-7211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 250g | 716994726

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eMolecules​ 106-96-7 | Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 1g | 537712114

Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical | 106-96-7211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 1g | 537712114

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eMolecules​ 106-96-7 | Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 25g | 537712116

Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical | 106-96-7211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 25g | 537712116

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Medchemexpress LLC Boc-Propargylamine | 92136-39-5 | 99.78% | C8H13NO2 | 100 G

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N-Boc-Propargylamine is a biochemical reagent and organic compound for life science research. It serves as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

• Prepares triazolobenzylidene-thiazolopyrimidines, which act as CDC25 phosphatase inhibitors.
• Synthesizes beta-glucan polysaccharide analogs.
• Involved in the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine to create 4,5-dissubstituted cyclopentenones.

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eMolecules​ 2197502-05-7 | 3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride | Combi-Blocks, Inc. | MFCD30489933 | 149.620 | C6H12ClNO | 97.000 | Cl.COC12CC(N)(C1)C2 | 5g | 818524322

3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride | Combi-Blocks, Inc. | 2197502-05-7 | MFCD30489933 | 149.620 | C6H12ClNO | 97.000 | Cl.COC12CC(N)(C1)C2 | 5g | 818524322

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STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 200 mg | CAS 171486-61-6 | MDL MFCD28976150

2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 200 mg. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 200 mg
- Net Weight: 0.2 g
- Gross Weight: 6.9 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C

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Medchemexpress LLC Propargyl-PEG4-amine 5g | 1013921-36-2 | 5 G

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Propargyl-PEG4-amine is an alkyne-terminated PEG4 linker with a primary amine, used in PROTAC linker assembly, click chemistry, and bioconjugation workflows. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amide bond formation for attaching payloads or linkers.

• Contains terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Primary amine enables amide coupling to activated carboxylic acids or NHS esters.
• Peg4 spacer provides flexibility and improved solubility in aqueous systems.
• Molecular weight 231.29 g/mol and formula C11H21NO4.
• High purity suitable for chemical biology and linker synthesis applications.

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Medchemexpress LLC Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-methanesulfonate | 943726-01-0 | 95.0% | 1 G

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Propargyl-PEG2-MS is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand with a target protein ligand via a linker.

• PEG-based PROTAC linker
• Functions as a click chemistry reagent
• Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Used in the synthesis of PROTACs
• Exploits the intracellular ubiquitin-proteasome system
• Selectively degrades target proteins
• Appears as a colorless to light yellow liquid

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Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1428629-71-3 | 97.0% | 313.30 g/mol | C14H19NO7 | 250 MG

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Propargyl-PEG3-NHS ester is an amine-reactive N-hydroxysuccinimide (NHS) ester with a terminal propargyl alkyne and a three-unit PEG spacer. It is designed for bioconjugation and linker chemistry, enabling amide bond formation with primary amines and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide partners.

• Amine-reactive NHS ester for stable amide bond formation.
• Terminal alkyne enables CuAAC click chemistry.
• Three-unit PEG spacer provides flexibility and solubility.
• Suitable for PROTAC and antibody-drug conjugate linker synthesis.
• High purity (97.0% by NMR) and molecular weight 313.30 g/mol.

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Medchemexpress LLC Propargyl-PEG3-CH2COOH | 1694731-93-5 | 98.0% | 25 MG

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Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker
• Click chemistry reagent with an alkyne group
• Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Used in the synthesis of PROTACs
• Exploits the ubiquitin-proteasome system to selectively degrade target proteins

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Medchemexpress LLC Bis-PEG1-C-PEG1-CH2COOH | 2358775-67-2 | 95.0% | 25 MG

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Bis-PEG1-C-PEG1-CH2COOH, also known as PROTAC Linker 26, is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are compounds designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, via a linker.

• PEG-based PROTAC linker
• Useful in the synthesis of PROTACs
• Facilitates selective degradation of target proteins
• Purity of 95.0%
• Molecular weight of 350.40
• Chemical formula C16H30O8
• Appears as an off-white to yellow oil
• Soluble in DMSO up to 100 mg/mL
• Recommended storage at -20°C for pure form

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