Acetylides

eMolecules​ 7758-99-8 | Copper(II) sulfate pentahydrate | Chem-Impex | MFCD00149681 | 249.680 | CuH10O9S | 99.000 | O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O | 2.5kg | 322127335

Copper(II) sulfate pentahydrate | Chem-Impex | 7758-99-8 | MFCD00149681 | 249.680 | CuH10O9S | 99.000 | O.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O | 2.5kg | 322127335

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Chemscene ChemScene | Boc-Propargylamine | 25G | CS-M0556 | 0.98 | 92136-39-5| MFCD07367245 | 155.19

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ChemScene | Boc-Propargylamine | 25G | CS-M0556 | 0.98 | 92136-39-5| MFCD07367245 | 155.19

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Medchemexpress LLC 4-pentynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 132178-37-1 | 99.8% | 195.17 g/mol | C9H9NO4 | 250 MG

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Propargyl-C1-NHS ester is an N-hydroxysuccinimide (NHS) ester bearing a propargyl (alkyne) handle used as a non-cleavable linker and click-chemistry reagent for antibody-drug conjugation and general bioconjugation. It couples to primary amines via NHS-ester chemistry and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners.

• Alkyne-functional NHS ester for click chemistry
• Suitable for antibody-drug conjugation and bioconjugation workflows
• Reacts with primary amines via NHS ester coupling
• Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
• High purity and available in multiple pack sizes, including 250 mg
• Soluble in DMSO; store sealed, away from moisture and light

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Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 500 MG

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Propargyl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.

• PEG-based PROTAC linker
• Can be used in the synthesis of BTK-IAP PROTACs
• Click chemistry reagent
• Contains an alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups

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Apexbio Technology LLC O-propargyl-puromycin (OPP)(Synonyms: OP-puromycin, Propargyl-puromycin, Puromycin alkyne, Alkyne-puromycin), 1mg, CAS: 1416561-90-4.

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O-propargyl-puromycin (OPP CAS 1416561-90-4) is an alkyne-functionalized derivative of puromycin commonly utilized to detect and quantify newly synthesized proteins It incorporates into nascent polypeptides by acting as a translation terminator covalently attaching to their C-terminal ends Subsequent detection occurs through azide-alkyne cycloaddition under copper(I) catalysis facilitating visualization or isolation of actively produced proteins In cellular and animal models OPP labeling enables measurement of global protein synthesis rates and assessment of responses to various stimuli or stress conditions contributing significantly to proteomics and cell biology research

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eMolecules​ 927-74-2 | 3-Butyn-1-ol | Oakwood Chemicals | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 5g | 480108297

3-Butyn-1-ol | Oakwood Chemicals | 927-74-2 | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 5g | 480108297

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eMolecules​ 927-74-2 | 3-Butyn-1-ol | Oakwood Chemicals | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 500g | 480108300

3-Butyn-1-ol | Oakwood Chemicals | 927-74-2 | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 500g | 480108300

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Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 250 MG

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Propargyl-PEG2-amine is a PEG-based propargyl-functionalized amine used as a short spacer linker for bioconjugation. It provides a terminal alkyne for click chemistry and a primary amine for conjugation, making it suitable for linker synthesis and medicinal chemistry research.

• Short PEG2 spacer with terminal alkyne for click chemistry.
• Primary amine for facile conjugation to activated esters and similar chemistries.
• High purity suitable for research-grade applications.
• Compact 250 MG packaging for laboratory-scale experiments.
• Soluble in common organic solvents used in synthesis and bioconjugation.

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Sigma Aldrich Fine Chemicals Biosciences Tetrahydro-2-(2-propynyloxy)-2H-pyran 98% | 6089-04-9 | MFCD00006604 | 100G

Tetrahydro-2-(2-propynyloxy)-2H-pyran 98% | Purity: 98% | Mol Wt: 140.18 | 6089-04-9 | MFCD00006604 | 100G

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Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 99.6% | 143.18 g/mol | C7H13NO2 | 5 G

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Propargyl-PEG2-amine is a short polyethylene glycol (PEG2) linker with a terminal propargyl (alkyne) group and a primary amine, used to introduce alkyne handles for click chemistry and bioconjugation.

• Short PEG2 spacer with terminal alkyne and primary amine.
• Suitable for click chemistry (CuAAC) and other bioconjugation reactions.
• Molecular weight 143.18 g/mol; formula C7H13NO2.
• Offered as a 5 g powder; store at 4°C, protect from light, under nitrogen.
• CAS number 944561-44-8 for unambiguous identification.

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eMolecules​ 86256-63-5 | 3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643

3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | 86256-63-5 | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643

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Medchemexpress LLC E -Pent-2-enal 10g

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(E)-Pent-2-enal has a pungent fruity odor This compound is commonly used in the flavor and fragrance industry because of its strong aroma often described as fresh and green Furthermore (E)-Pent-2-enal can be used as an intermediate in the synthesis of various organic compounds including pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in many commercial products including perfumes air fresheners and cleaners

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eMolecules​ 2007921-20-0 | 3-AMINOBICYCLO[1.1.1]PENTAN-1-OL HCL | AstaTech | MFCD28501812 | 135.590 | C5H10ClNO | 95.000 | Cl.NC12CC(O)(C1)C2 | 0.1g | 323615419

3-AMINOBICYCLO[1.1.1]PENTAN-1-OL HCL | AstaTech | 2007921-20-0 | MFCD28501812 | 135.590 | C5H10ClNO | 95.000 | Cl.NC12CC(O)(C1)C2 | 0.1g | 323615419

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Medchemexpress LLC 2-[2-(2-propynyloxy)ethoxy]ethanamine | 944561-44-8 | MFCD19160595 | 98.9% | 143.18 g/mol | C7H13NO2 | 25 G

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Propargyl-PEG2-amine is a propargyl-terminated polyethylene glycol (PEG2) amine linker used for bioconjugation and synthetic chemistry. It is commonly used as a non-cleavable ADC linker, as a PEG-based PROTAC linker, and as a terminal alkyne reagent for copper-catalyzed azide-alkyne cycloaddition (click chemistry).

• Non-cleavable ADC linker for antibody-drug conjugate synthesis.
• Suitable as a PEG-based PROTAC linker.
• Terminal alkyne enables CuAAC click reactions with azides.
• Primary amine allows amide coupling and NHS-ester chemistry.
• Molecular formula C7H13NO2 and molecular weight 143.18 g/mol.
• High reported purity (manufacturer batch example ~98.9%), batch-dependent.
• Available in multiple pack sizes, including 25 G and larger quantities.

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Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG

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This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.

• Application: Can be employed in the synthesis of PROTACs.
• Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.

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