Acetylides

Chemscene ChemScene | Boc-Propargylamine | 25G | CS-M0556 | 0.98 | 92136-39-5| MFCD07367245 | 155.19

ChemScene | Boc-Propargylamine | 25G | CS-M0556 | 0.98 | 92136-39-5| MFCD07367245 | 155.19

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Medchemexpress LLC 4-pentynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 132178-37-1 | 99.8% | 195.17 g/mol | C9H9NO4 | 250 MG

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Propargyl-C1-NHS ester is an N-hydroxysuccinimide (NHS) ester bearing a propargyl (alkyne) handle used as a non-cleavable linker and click-chemistry reagent for antibody-drug conjugation and general bioconjugation. It couples to primary amines via NHS-ester chemistry and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners.

• Alkyne-functional NHS ester for click chemistry
• Suitable for antibody-drug conjugation and bioconjugation workflows
• Reacts with primary amines via NHS ester coupling
• Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
• High purity and available in multiple pack sizes, including 250 mg
• Soluble in DMSO; store sealed, away from moisture and light

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Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 500 MG

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Propargyl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.

• PEG-based PROTAC linker
• Can be used in the synthesis of BTK-IAP PROTACs
• Click chemistry reagent
• Contains an alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups

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Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 250 MG

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Propargyl-PEG2-amine is a PEG-based propargyl-functionalized amine used as a short spacer linker for bioconjugation. It provides a terminal alkyne for click chemistry and a primary amine for conjugation, making it suitable for linker synthesis and medicinal chemistry research.

• Short PEG2 spacer with terminal alkyne for click chemistry.
• Primary amine for facile conjugation to activated esters and similar chemistries.
• High purity suitable for research-grade applications.
• Compact 250 MG packaging for laboratory-scale experiments.
• Soluble in common organic solvents used in synthesis and bioconjugation.

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Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) hex-5-ynoate | 906564-59-8 | MFCD28898858 | 97.0% | 209.20 g/mol | C10H11NO4 | 50 MG

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Propargyl-C2-NHS ester is an alkyne-containing N-hydroxysuccinimide (NHS) ester used for bioconjugation. It serves as a non-cleavable linker and a click-chemistry reagent enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-bearing molecules.

• Contains a propargyl (alkyne) group for CuAAC reactions.
• Designed for antibody conjugation and general bioconjugation.
• Molecular formula C10H11NO4; molecular weight 209.20 g/mol.
• High purity: 97.0%.
• Stored at -20°C in pure form; available in small pack sizes for research use.

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Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | 471.38 | C19H35BrO8 | 100 MG

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Propargyl-PEG8-bromide is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal bromide. It is used for bioconjugation and linker synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and functioning as a non-cleavable ADC and PROTAC linker.

• Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
• Provides an eight-unit polyethylene glycol spacer for flexibility and solubility.
• Has a terminal bromide for nucleophilic substitution or further functionalization.
• Suitable for ADC and PROTAC linker synthesis and click chemistry applications.
• Available in small-scale laboratory quantities for research use.

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Medchemexpress LLC Propargyl-PEG2-bromi 250mg

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Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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eMolecules​ 1066-54-2 | TRIMETHYLSILYLACETYLENE | AstaTech | MFCD00008569 | 98.220 | C5H10Si | 97.000 | C[Si](C)(C)C#C | 25g | 387752353

TRIMETHYLSILYLACETYLENE | AstaTech | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 97.000 | C[Si](C)(C)C#C | 25g | 387752353

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Medchemexpress LLC Propargyl-PEG4-Br | 1308299-09-3 | 5 G

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Propargyl-PEG4-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

• Functions as a PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Acts as a non-cleavable ADC linker
• Utilized in the synthesis of antibody-drug conjugates (ADCs)
• Serves as a click chemistry reagent
• Contains an Alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 99.6% | 143.18 g/mol | C7H13NO2 | 5 G

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Propargyl-PEG2-amine is a short polyethylene glycol (PEG2) linker with a terminal propargyl (alkyne) group and a primary amine, used to introduce alkyne handles for click chemistry and bioconjugation.

• Short PEG2 spacer with terminal alkyne and primary amine.
• Suitable for click chemistry (CuAAC) and other bioconjugation reactions.
• Molecular weight 143.18 g/mol; formula C7H13NO2.
• Offered as a 5 g powder; store at 4°C, protect from light, under nitrogen.
• CAS number 944561-44-8 for unambiguous identification.

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eMolecules​ 86256-63-5 | 3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643

3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | 86256-63-5 | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643

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Medchemexpress LLC Propargyl-PEG1-NHS ester | 1174157-65-3 | 99.7% | 225.20 g/mol | C10H11NO5 | 5 G

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Propargyl-PEG1-NHS ester is a short PEG linker bearing a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester for selective amine conjugation. It is used in click chemistry and bioconjugation workflows, including antibody-drug conjugate synthesis.

• Provides a short, flexible PEG spacer to reduce steric hindrance
• Contains an NHS ester for efficient amine coupling
• Has a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
• High purity suitable for research applications
• Soluble in DMSO and stable when stored at low temperatures

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STA Pharmaceutical 2'-propargyl G(iBu) amidite | 5 g | CAS 171486-61-6 | MDL MFCD28976150

2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 250 mL Glass (28-400)
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 174.7 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C

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eMolecules​ 881402-25-1 | 2-Fluoro-3-(trifluoromethoxy)benzeneboronic acid | Apollo Scientific | MFCD11045053 | 223.920 | C7H5BF4O3 | 95.000 | OB(O)c1cccc(OC(F)(F)F)c1F | 1g | 562441206

2-Fluoro-3-(trifluoromethoxy)benzeneboronic acid | Apollo Scientific | 881402-25-1 | MFCD11045053 | 223.920 | C7H5BF4O3 | 95.000 | OB(O)c1cccc(OC(F)(F)F)c1F | 1g | 562441206

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eMolecules​ 2007921-20-0 | 3-AMINOBICYCLO[1.1.1]PENTAN-1-OL HCL | AstaTech | MFCD28501812 | 135.590 | C5H10ClNO | 95.000 | Cl.NC12CC(O)(C1)C2 | 0.1g | 323615419

3-AMINOBICYCLO[1.1.1]PENTAN-1-OL HCL | AstaTech | 2007921-20-0 | MFCD28501812 | 135.590 | C5H10ClNO | 95.000 | Cl.NC12CC(O)(C1)C2 | 0.1g | 323615419

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