Acetylides
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 g/mol | C10H16O5 | 5 G
Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid. It is used in bioconjugation and medicinal chemistry applications such as click chemistry and PROTAC or ADC linker construction.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
- Three-unit PEG spacer improves solubility and flexibility
- Carboxylic acid functionality enables standard coupling chemistries
- High purity (99.14%) and liquid form, colorless to light yellow
- Available in multiple sizes, including a 5 g package; recommended storage: -20°C for long-term stability
![Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204167.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG
Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) group and a disulfide bond, terminating in a carboxylic acid. It is intended for click-chemistry-enabled bioconjugation and as a reducible linker in antibody-drug conjugate synthesis.
- Cleavable disulfide linkage for reductive release.
- Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition.
- Carboxylic acid terminus for amide coupling or further functionalization.
- Purity typically ≥95%.
- Available in multiple sizes, including 100 mg.
- Stable when stored under recommended temperatures.
eMolecules 2-Bromo-5-(trifluoromethoxy)phenylisocyanate | Apollo Scientific |282.016 | C8H3BrF3NO2 | 95.000 | FC(F)(F)Oc1ccc(Br)c(c1)N=C=O | 25g | 562453349
2-Bromo-5-(trifluoromethoxy)phenylisocyanate | Apollo Scientific |282.016 | C8H3BrF3NO2 | 95.000 | FC(F)(F)Oc1ccc(Br)c(c1)N=C=O | 25g | 562453349
Medchemexpress LLC Propargyl-PEG6-NHS ester | 2093153-99-0 | 98.0% | 445.46 g/mol | C20H31NO10 | 250 MG
Propargyl-PEG6-NHS ester is an alkyne-functionalized polyethylene glycol (PEG6) N-hydroxysuccinimide (NHS) ester used for bioconjugation and linker synthesis. It reacts with primary amines to form stable amide bonds and provides an alkyne handle suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
- Amine-reactive NHS ester for stable amide bond formation.
- Alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Peg6 spacer to improve solubility and reduce steric hindrance.
- High purity suitable for synthetic bioconjugation workflows.
- Available in small pack sizes for laboratory-scale synthesis.
Medchemexpress LLC E -Pent-2-enal 5g
(E)-Pent-2-enal has a pungent fruity odor This compound is commonly used in the flavor and fragrance industry because of its strong aroma often described as fresh and green Furthermore (E)-Pent-2-enal can be used as an intermediate in the synthesis of various organic compounds including pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in many commercial products including perfumes air fresheners and cleaners
Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | MFCD29042377 | 95.0% | 471.38 | C19H35BrO8 | 250 MG
Propargyl-PEG8-bromide is a bifunctional PEG-based reagent containing a terminal alkyne and a bromide leaving group, used as a non-cleavable linker in antibody-drug conjugate (ADC) and PROTAC synthesis and as a reagent for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a PEG8 spacer to increase solubility and flexibility.
- Contains a bromide leaving group for nucleophilic substitution reactions.
- Functions as a non-cleavable linker suitable for ADC and PROTAC assembly.
- Molecular weight approximately 471.4 and formula C19H35BrO8.
- Typically supplied in mg-scale quantities for research use.
Medchemexpress LLC Propargyl-PEG1-SS-PEG1-t-butyl ester | 1807518-78-0 | MFCD28505559 | >98.0% | 320.47 g/mol | C14H24O4S2 | 10 MG
Propargyl-PEG1-SS-PEG1-t-butyl ester is a cleavable PEG-based linker containing terminal propargyl (alkyne) groups and a disulfide bond. It is used in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and as a click-chemistry handle for azide-alkyne cycloaddition.
- Cleavable disulfide linkage allows intracellular reduction and payload release.
- Terminal propargyl groups enable copper-catalyzed and strain-promoted click reactions.
- High purity (>98.0%) suitable for synthetic chemistry applications.
- Molecular weight 320.47 g/mol and formula C14H24O4S2.
- Available in small research quantities (5 mg, 10 mg, 25 mg) for lab-scale synthesis.
Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | 98.7% | 224.28 g/mol | C11H12O3S | 10 G
An alkyne-bearing p-toluenesulfonate ester used as a click-chemistry reagent and cleavable linker for antibody-drug conjugate synthesis; it undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Reacts in copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Molecular formula C11H12O3S; molecular weight 224.28 g/mol.
- CAS number 23418-85-1.
- Purity typically 98.7%.
- Appearance colorless to light yellow liquid.
- Available in 1 g, 5 g, 10 g, and 50 g package sizes.
Medchemexpress LLC VH032-PEG3-acetylene | 2098799-80-3 | 98.1% | 25 MG
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. This compound is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a VH032 based VHL ligand
- Utilizes a linker employed in PROTAC technology
- Functions as a click chemistry reagent
- Contains an alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG8-NHS ester | 2182601-74-5 | MFCD31536764 | >95.0% | 533.57 g/mol | C24H39NO12 | 250 MG
Propargyl-PEG8-NHS ester is an amine-reactive polyethylene glycol (PEG) linker bearing a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) activated ester. It is used for bioconjugation, click chemistry, and as a linker in ADC/PROTAC synthesis, providing improved solubility and site-selective attachment.
- Amine-reactive NHS ester for efficient conjugation to primary amines.
- Terminal propargyl alkyne enables copper-catalyzed or strain-promoted click reactions.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity typically ≥95% for reliable biochemical use.
- Molecular weight approximately 533.57 g/mol, suitable for linker applications.
- Available as a 250 MG solid for laboratory-scale synthesis.
Medchemexpress LLC VQW-765 (AQW-051) | 669770-29-0 | 99.58% | 294.39 | 5 MG
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist. It demonstrates a pKD value of 7.56 to recombinantly expressed human α7-nAChR and exhibits anxiolytic-like effects in vivo. This compound can be used for research into anxiety disorder and acute performance anxiety.
- Selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist
- Demonstrates potent agonist activity to calcium transients
- Enhances cognitive effect and learning/memory performance
- Shows anxiolytic-like effects in vivo
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
eMolecules 1703955-84-3 | 5-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific267.180 | C10H9F4NO3 | 95.000 | NC(Cc1cc(F)ccc1OC(F)(F)F)C(O)=O | 1g | 562457991
5-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | 1703955-84-3267.180 | C10H9F4NO3 | 95.000 | NC(Cc1cc(F)ccc1OC(F)(F)F)C(O)=O | 1g | 562457991