Acetylides
eMolecules Ambeed / 4-Bromobutyryl chloride / 1g / 570996278 / A708194 / / 927-58-2 / MFCD00000753 / 185.450 / C4H6BrClO
Ambeed / 4-Bromobutyryl chloride / 1g / 570996278 / A708194 / / 927-58-2 / MFCD00000753 / 185.450 / C4H6BrClO
Sigma Aldrich Fine Chemicals Biosciences Cyclopropylacetylene Neat, 97% | 6746-94-7 | MFCD02181090 | 25G
Cyclopropylacetylene Neat, 97% | Purity: 97% | Mol Wt: 66.1 | 6746-94-7 | MFCD02181090 | 25G
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 60 mL Glass (Septum)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 38.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 100 MG
Propargyl-PEG8-OH is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent contains an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 100 MG
Propargyl-PEG8-Boc is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This click chemistry reagent features an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing Azide groups. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Reacts with azide-containing molecules
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 5 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Molecular weight: 408.48
- Formula: C19H36O9
- Relevant for cancer and cancer targeted therapy
eMolecules 4-Chloro-3-(trifluoromethoxy)phenol | 886500-85-2 | MFCD06660247 | 1g
Apollo Scientific | 4-Chloro-3-(trifluoromethoxy)phenol | 1g | 562453315 | PC302060 | 98.000 | 886500-85-2 | MFCD06660247 | 212.550 | C7H4ClF3O2
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Medchemexpress LLC Propargyl-PEG7-acid | 2093154-00-6 | ≥98.0% | 1 G
Propargyl-PEG7-acid is a PEG-based PROTAC linker and a cleavable ADC linker, making it valuable for synthesizing PROTACs and antibody-drug conjugates. It also functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Used in the synthesis of PROTACs
- Cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Functions as a click chemistry reagent
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 1 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | 5 G
Propargyl-PEG6-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing Azide groups.
- Peg-based protac linker for protac synthesis.
- Cleavable adc linker for antibody-drug conjugate synthesis.
- Click chemistry reagent containing an alkyne group.
- Enables copper-catalyzed azide-alkyne cycloaddition (cuaac) with azide groups.
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 1 G
Propargyl-PEG8-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This compound is instrumental in developing PROTACs, which are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Interacts with Azide groups
- Facilitates selective degradation of target proteins
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 10 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and analogue PROTAC 3, which causes BTK degradation. Propargyl-PEG4-acid is also a click chemistry reagent, featuring an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in synthesis of BTK-IAP PROTACs
- PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells
- Click chemistry reagent with Alkyne group
- Can undergo CuAAc with Azide groups
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 50 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups
Medchemexpress LLC Propargyl-PEG1-NHS ester | 1174157-65-3 | 98.9% | 225.20 g/mol | C10H11NO5 | 1 G
Propargyl-PEG1-NHS ester is a small polyethylene glycol (PEG1) linker bearing an N-hydroxysuccinimide (NHS) ester and a terminal propargyl (alkyne) group. It is designed to derivatize primary amines via NHS chemistry and to introduce an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions, enabling bioconjugation and linker construction.
- Reactive NHS ester for conjugation to primary amines.
- Terminal alkyne (propargyl) enables CuAAC click chemistry.
- Small PEG1 spacer reduces steric hindrance and improves solubility.
- Typical assay purity reported around 98.9%.
- Stable when stored at -20°C in pure form for extended periods.
Medchemexpress LLC Bis-PEG1-C-PEG1-CH2COOH | 2358775-67-2 | MFCD22381072 | 95.0% | 350.40 | C16H30O8 | 5 MG
Bis-PEG1-C-PEG1-CH2COOH is a PEG-based bifunctional linker bearing a terminal carboxylic acid; it serves as a building block for the synthesis of PROTACs and other conjugates. The material is supplied as an off-white to yellow oil, and is typically offered at research-grade purity for small-scale synthetic work.
- PEG-based bifunctional linker for PROTAC and conjugate synthesis.
- Terminal carboxylic acid enables standard amide or ester coupling reactions.
- Low molecular weight building block (MW 350.4) for modular design.
- Supplied as an off-white to yellow oil suitable for solution-phase synthesis.
- High purity appropriate for research applications (95.0%).
- Available in small pack sizes for screening and library synthesis.