Hydrobromides
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 50 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It works by inhibiting NAT10 activity, which in turn slows down DNA replication and suppresses the growth of prostate cancer cells. This compound has been shown to inhibit the growth of both prostate cancer and hepatocellular carcinoma in xenograft models. Additionally, it enhances the healthspan in a mouse model of Hutchinson-Gilford progeria syndrome (HGPS).
- Orally active and selective inhibitor.
- Inhibits NAT10 activity.
- Slows DNA replication.
- Suppresses growth of prostate cancer cells.
- Inhibits growth of hepatocellular carcinoma in xenograft models.
- Enhances healthspan in a mouse model of HGPS.
Selleck Chemical LLC Arecoline HBr S2614-1g
Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 100 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It inhibits NAT10 activity, slows DNA replication, and suppresses the growth of prostate cancer cells. It has been shown to inhibit the growth of prostate cancer and hepatocellular carcinoma in xenograft models. Additionally, Remodelin hydrobromide enhances the healthspan in the Hutchinson-Gilford progeria syndrome (HGPS) mouse model.
- Inhibits NAT10 activity and cell proliferation in prostate cancer cells.
- Slows DNA replication.
- Suppresses the growth of prostate cancer cells.
- Inhibits the growth of hepatocellular carcinoma in xenograft models.
- Enhances healthspan in the HGPS mouse model.
- Decreases nuclear shape defects and increases genomic stability in fibroblasts.
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 100.0% | 349.29 | 50 MG
Pifithrin-β hydrobromide, also known as PFT β hydrobromide, is a potent p53 inhibitor with an IC50 of 23 μM. It is related to Pifithrin-α, a lead compound for cancer and neurodegenerative disease therapy, which rapidly converts to Pifithrin-β, its N-acetyl derivative. Pretreatment with 1 and 10 μM pifithrin-β has shown neuroprotective effects.
- Potent p53 inhibitor
- Exerts neuroprotective effects
- Used in cancer and neurodegenerative disease research
Medchemexpress LLC CPTH6 hydrobromide 1mg | 2321332-57-2 | 1 MG
CPTH6 hydrobromide is a thiazole-derived small molecule that modulates histone acetyltransferase activity and induces apoptotic and autophagic features in leukemia cell lines. It is provided as the hydrobromide salt for use in biochemical and cell-based cancer research applications.
- Thiazole-derived HAT inhibitor that reduces histone acetylation.
- Promotes apoptotic program and increases autophagic features in leukemia cells.
- Provided as a solid hydrobromide salt for improved handling and stability.
- Suitable for biochemical assays and cell-based studies of acetylation-dependent processes.
- Supplied in small research quantities for screening and mechanistic experiments.
Medchemexpress LLC BC-11 hydrobromide | 443776-49-6 | 99.0% | 290.97 | 50 MG
BC-11 hydrobromide is a selective TMPRSS2 inhibitor, which is a crucial host cellular factor for viral entry and SARS-CoV-2 pathogenesis. It also acts as a selective urokinase (uPA) inhibitor with an IC50 of 8.2 μM. This compound exhibits cytotoxicity towards triple-negative MDA-MB231 breast cancer cells, making it relevant for research on viral infections and cancer.
- A selective TMPRSS2 inhibitor.
- A selective urokinase inhibitor.
- Cytotoxic to triple-negative MDA-MB231 breast cancer cells.
- Used in research on viral infections and cancer.
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
eMolecules ChemScene N-Boc-4-bromopiperidine 25g 536904869 CS-W001478 180695-79-8 MFCD04115039 264.163 C10H18BrNO2
ChemScene N-Boc-4-bromopiperidine 25g 536904869 CS-W001478 180695-79-8 MFCD04115039 264.163 C10H18BrNO2
Medchemexpress LLC SCH-202676 (hydrobromide) | 265980-25-4 | 96.8% | 348.26 | 25 MG
SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). It exhibits antiviral activity, inhibiting 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM.
- Allosteric modulator of G protein-coupled receptors (GPCRs)
- Allosteric modulator of adenosine receptor (AR)
- Antiviral activity
- Inhibits 3CLpro in a time-dependent manner
TARGETMOL CHEMICALS INC PIFITHRIN-BETA HYDROBROM 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pifithrin-(beta) hydrobromide (Cyclic PFT-(alpha)) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 uM). purity: 99%
Medchemexpress LLC Oxidopamine (hydrobromide) | 636-00-0 | 99.4% | 200 MG
Oxidopamine (hydrobromide) | 636-00-0 | 99.4% | 200 MG