Hydrobromides
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 25 MG
Halofuginone hydrobromide, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor. It specifically inhibits type-I collagen synthesis and helps reduce osteoarthritis by inhibiting TGF-β activity. It also acts as a potent pulmonary vasodilator by activating Kv channels and blocking various Ca2+ channels. This compound exhibits a range of beneficial effects.
- Competitively inhibits prolyl-tRNA synthetase
- Inhibits type-I collagen synthesis
- Attenuates osteoarthritis by inhibiting TGF-β activity
- Potent pulmonary vasodilator
- Activates Kv channels and blocks Ca2+ channels
- Exhibits anti-malaria effects
- Provides anti-inflammatory effects
- Shows anti-cancer activity
- Offers anti-fibrosis effects
- Decreases NRF2 protein levels in tumors
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 1 ML
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10, which inhibits NAT10 activity and slows DNA replication.
- Suppresses the growth of prostate cancer cells.
- Inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft models.
- Enhances the healthspan in a Hutchinson-Gilford progeria syndrome (HGPS) mouse model.
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 99.97% | 349.29 | 25 MG
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM. It is considered a lead compound for the treatment of cancer and neurodegenerative diseases.
- Potent p53 inhibitor
- Considered a lead compound for cancer and neurodegenerative disease therapy
- Pifithrin-α quickly converts to pifithrin-β in culture medium
- Pretreatments can exert neuroprotective effects after 24 hours
TARGETMOL CHEMICALS INC Clobenpropit dihydrobromide
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07) Purity 99.48%
Apexbio Technology LLC Scopolamine hydrobromide 114-49-8 500mg
Scopolamine hydrobromide (114-49-8) is a small-molecule antagonist targeting muscarinic acetylcholine receptors and serotonin 5-HT3 receptors It is designed to reversibly block these receptors thereby modulating cholinergic and serotonergic signaling pathways Scopolamine hydrobromide exerts its biological activity primarily through reversible antagonism of muscarinic receptors and inhibition of serotonin 5-HT3 receptor responses In receptor binding studies Scopolamine hydrobromide demonstrates antagonistic activity with reported IC50 values generally ranging from nanomolar to micromolar concentrations depending on the receptor subtype and experimental conditions Based on these pharmacological properties Scopolamine hydrobromide holds research potential in studies of neurotransmission cholinergic signaling gastrointestinal motility assays cognitive impairment models and emesis reflex investigations