Hydrobromides
TARGETMOL CHEMICALS INC TAZEMETOSTAT HYDROBROMID 100MG
Also available in 2 mg 5 mg 10 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50 392 nM). purity: 99%
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | MFCD00946455 | 100.0% | 495.59 g/mol | C16H18Br2ClN3O3 | 10 MG
Halofuginone hydrobromide is the hydrobromide salt of halofuginone, a febrifugine-derived small molecule that competitively inhibits prolyl-tRNA synthetase and is supplied for research applications studying fibrosis, inflammation, malaria, and cancer. It is provided as a white to off-white solid with high purity and defined storage and solvent recommendations.
- Hydrobromide salt for improved handling and solubility.
- Competitive prolyl-tRNA synthetase inhibitor used in mechanistic research.
- High purity suitable for research applications.
- White to off-white solid, soluble in DMSO (≈50 mg/mL) and water (≈2.6 mg/mL).
- Store sealed and away from moisture; in solution keep at -80°C for long-term stability.
- Applicable for preclinical studies of fibrosis, inflammation, malaria, and cancer pathways.
TARGETMOL CHEMICALS INC PIFITHRIN-BETA HYDROBROM 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pifithrin-(beta) hydrobromide (Cyclic PFT-(alpha)) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 uM). purity: 99%
Medchemexpress LLC Nan-190 hydrobromide | 115338-32-4 | 99.1% | 474.39 | 200 MG
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist that selectively targets the 5-HT1A receptor. This compound is intended for research use only. In vivo studies demonstrate its ability to reverse the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats.
- Selective antagonist of 5-HT1A receptor
- Antagonist of 5-HT1 receptor
- Suitable for research applications
Medchemexpress LLC Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 1 G
Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 1 G
Medchemexpress LLC CCT031374 hydrobromide | 1219184-91-4 | 98.1% | 434.33 | 100 MG
CCT 031374 hydrobromide is a potent inhibitor of β-catenin/transcription factor (TCF) complex signaling. It inhibits TCF-dependent transcription of genes in the Wnt signaling pathway and exhibits antitumor activity.
- Potent inhibitor of β-catenin/transcription factor (TCF) complex signaling.
- Inhibits TCF-dependent transcription of genes of Wnt signaling pathway.
- Has antitumor activity.
- For research use only.
Medchemexpress LLC BC-11 hydrobromide | 443776-49-6 | 99.0% | 290.97 | 50 MG
BC-11 hydrobromide is a selective TMPRSS2 inhibitor, which is a crucial host cellular factor for viral entry and SARS-CoV-2 pathogenesis. It also acts as a selective urokinase (uPA) inhibitor with an IC50 of 8.2 μM. This compound exhibits cytotoxicity towards triple-negative MDA-MB231 breast cancer cells, making it relevant for research on viral infections and cancer.
- A selective TMPRSS2 inhibitor.
- A selective urokinase inhibitor.
- Cytotoxic to triple-negative MDA-MB231 breast cancer cells.
- Used in research on viral infections and cancer.
Medchemexpress LLC Carbamimidothioic acid, C,C'-(1,4-phenylenedi-2,1-ethanediyl) ester, hydrobromide (1:2) | 157254-60-9 | 98.0% | C12H20Br2N4S2 | 10MG
1,4-PBIT (dihydrobromide) is the dihydrobromide salt of the small-molecule 1,4-PBIT, supplied for research use. The compound is documented by manufacturer COA and SDS, and is provided as a white to off-white solid with molecular formula C12H20Br2N4S2, molecular weight 444.25, and reported purity 98.0%.
- 98.0% purity as reported on the certificate of analysis
- White to off-white solid form for solid-handling workflows
- Molecular formula C12H20Br2N4S2 and molecular weight 444.25
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month), sealed
- Used as a nitric oxide synthase inhibitor in research applications
Medchemexpress LLC Burixafor (hydrobromide) | 1191450-19-7 | 98.0% | 769.01 | 1 ML
Burixafor hydrobromide is a potent CXCR4 antagonist that inhibits the binding of CXCL12 to CXCR4 and blocks downstream signaling. It mobilizes CD34+ hematopoietic stem/progenitor cells from bone marrow to peripheral blood. This compound is used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4.
- Inhibits binding of CXCL12 to CXCR4.
- Mobilizes CD34+ hematopoietic stem/progenitor cells.
- Useful for research on autologous hematopoietic stem cell transplantation.
Medchemexpress LLC SCH-202676 hydrobromide | 265980-25-4 | 96.81% | 348.26 | 1 MG
SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). It exhibits antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM.
- Allosteric modulator of G protein-coupled receptors (GPCRs)
- Allosteric modulator of adenosine receptor (AR)
- Antiviral activity
- Inhibits 3CLpro in a time-dependent manner
- IC50 value of 0.655 μM against 3CLpro
Medchemexpress LLC Arecoline | 63-75-2 | MFCD00005704 | 1 ML
Arecoline is a naturally occurring psychoactive alkaloid that is brain-penetrant and orally active. It acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors. This compound has been observed to exhibit stimulation, alertness, anxiolysis, and anti-parasitic effects, though it can also induce oxidative stress.
- Purity: 99.84%
- Molecular weight: 155.19
- Formula: C8H13NO2
- Appearance: liquid
- Color: light yellow to brown
- Structure classification: alkaloids, piperidine alkaloids
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Induces stimulation, alertness, anxiolysis, and anti-parasitic effects
- Can alleviate anxiety and depression in CFA-induced mice