Hydrobromides
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
Apexbio Technology LLC 6-Hydroxydopamine hydrobromide(Synonyms: Oxidopamine hydrobromide, 6-OHDA hydrobromide, 6-Hydroxydopamine HBr), 50mg, CAS: 636-00-0.
6-Hydroxydopamine hydrobromide (CAS 636-00-0) commonly referred to as 6-OHDA hydrobromide is a catecholamine-derived neurotoxin frequently used in neuroscience research to induce selective dopaminergic neuronal degeneration Upon administration it generates intracellular reactive oxygen species (ROS) activating apoptotic pathways via caspase-3 -8 and -9 as demonstrated in PC12 cell studies In rodent models targeted injection into substantia nigra striatum or medial forebrain bundle leads to loss of tyrosine hydroxylase-positive neurons and resultant locomotor dysfunction resembling symptoms observed in Parkinson s disease Consequently it serves as a valuable tool for elucidating dopaminergic dysfunction mechanisms and evaluating therapeutic candidates
Medchemexpress LLC (RS)-AMPA hydrobromide | 171259-81-7 | 99.5% | 267.08 g/mol | C7H11BrN2O4 | 10 MG
(RS)-AMPA hydrobromide is the hydrobromide salt of (RS)-AMPA, a glutamate analogue and selective agonist of AMPA-type glutamate receptors. Supplied as a white to off-white solid for research use in neuroscience and pharmacology studies where a water-soluble AMPA receptor agonist is required.
- Selective AMPA receptor agonist.
- CAS number 171259-81-7.
- Molecular weight 267.08 g/mol.
- Purity 99.5%.
- White to off-white solid.
- Solubility: DMSO 50 mg/mL; H2O 5 mg/mL (may require ultrasonic).
- Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 5mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Apexbio Technology LLC SR 95531 hydrobromide 104104-50-9 5mg
SR 95531 hydrobromide (CAS 104104-50-9) also known as Gabazine is a selective competitive antagonist of the GABAA receptor By binding to the GABA recognition site on the receptor it blocks the activation induced by -aminobutyric acid (GABA) Experimental studies report an inhibitory concentration (IC50) of approximately 0 2 M for GABAA receptor-mediated responses Widely utilized in neuroscience research Gabazine is applied to investigate the physiological and pathological roles of GABAA receptor-mediated synaptic transmission neural network modulation and neurotransmitter regulation
Apexbio Technology LLC Arecoline hydrobromide 300-08-3 10mM (in 1mL DMSO)
Arecoline hydrobromide (CAS 300-08-3) is a nicotinic alkaloid that acts as a partial agonist at muscarinic acetylcholine receptors M1 M4 In electrophysiological studies it significantly inhibits the hERG potassium channel current with an IC50 of 9 55 mol/L The compound s inhibitory effect on IhERG displays concentration time and voltage dependency with blockade intensity influenced by stimulation frequency Subcutaneous administration in mice yields an LD50 of 100 mg/kg Arecoline hydrobromide is utilized in research on cardiac electrophysiology and muscarinic receptor pharmacology particularly for investigating frequency- and state-dependent modulation of cardiac ion channels
TARGETMOL CHEMICALS INC Arecoline 500MG
Also available in 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can induce oxidative stress and can be used to study Alzheimer's disease and Alzheimer's disease. Purity 99.28%