Hydrochlorides
Medchemexpress LLC RS-102221 hydrochloride | 187397-18-8 | 98.0% | 649.08 g/mol | C27H32ClF3N4O7S | 25 MG
RS-102221 hydrochloride is the hydrochloride salt of a selective 5-HT2C receptor antagonist commonly used in neuroscience research. It demonstrates high affinity for 5-HT2C receptors and is supplied in both solid and solution forms for in vitro and in vivo studies, with specified purity and storage recommendations.
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 g/mol | C11H17ClN2O3 | 1 ML
Nifenalol hydrochloride is a β-adrenergic receptor antagonist used in cardiovascular and cardiac electrophysiology research. The product is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and is accompanied by standard documentation for handling and quality verification.
- β-adrenergic receptor antagonist for cardiac research.
- High purity suitable for research applications.
- Supplied as a 10 mM solution in DMSO, 1 mL volume.
- White to off-white solid appearance when provided as a solid.
- Includes data sheet, COA, and SDS for safety and compliance.
- Storage recommendations provided for solid and solution forms.
Medchemexpress LLC Tak-960 dihydrochloride | 2320307-83-1 | C27H36Cl2F3N7O3 | 10 MM 1 ML
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 nM and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and demonstrates significant efficacy against various tumor xenografts.
- Acts as a selective inhibitor of polo-like kinase 1 (PLK1)
- Shows inhibitory activities against PLK2 and PLK3
- Causes accumulation of G2-M cells
- Leads to aberrant polo mitosis morphology
- Increases phosphorylation of histone H3 (pHH3)
- Induces G2/M cell cycle arrest in HeLa cells without significant cytotoxicity
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against multiple tumor xenografts
Medchemexpress LLC UAMC-3203 hydrochloride | 2271358-65-5 | 98.1% | 508.12 | 50 MG
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. It is for research use only and not sold to patients. No toxicity was observed in mice after repeated intraperitoneal injections (20 μmol/kg daily, over 4 weeks).
- Potent and selective Ferroptosis inhibitor.
- IC50 of 12 nM for Ferroptosis.
- Inhibits erastin-induced ferroptosis in human IMR32 cells with an IC50 of 10 nM.
- No observed toxicity in mice at 20 μmol/kg over 4 weeks.
eMolecules 2318-25-4 | Ethyl 3-ethoxy-3-iminopropionate hydrochloride | Combi-Blocks | MFCD00051405 | 195.640 | C7H14ClNO3 | 97.000 | Cl.CCOC(=N)CC(=O)OCC | 5g | 205404678
Ethyl 3-ethoxy-3-iminopropionate hydrochloride | Combi-Blocks | 2318-25-4 | MFCD00051405 | 195.640 | C7H14ClNO3 | 97.000 | Cl.CCOC(=N)CC(=O)OCC | 5g | 205404678
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 50 MG
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. It is intended for research use only and not sold to patients. This compound is a white to off-white solid with 99.99% purity.
- Potent and selective P2X7 receptor antagonist
- pIC50 of 6.9
- For research use only
- High purity (99.99%)
- White to off-white solid
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death in the hippocampus
- Prevents depletion of striatal DA stores
- Reduces nociceptive behaviour scores
Medchemexpress LLC Erlotinib hydrochloride | 183319-69-9 | 99.7% | 25 MG
Erlotinib hydrochloride analytical standard, the hydrochloride salt of erlotinib, provided as a high-purity solid for use as a reference material in biochemical and analytical assays.
- Analytical standard for erlotinib hydrochloride.
- Purity 99.73% (analytical).
- Molecular weight 429.90 g/mol.
- Chemical formula C22H24ClN3O4.
- Appearance: white to off-white solid.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg; 200 mg and 500 mg available by quote.
- Store under conditions specified on the certificate of analysis.
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 50 MG
RS-127445 hydrochloride is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. It is intended for research use only.
- Selective 5-HT2B receptor antagonist
- High-affinity binding
- Orally bioavailable
- Demonstrates 1000-fold selectivity
- Suitable for research applications
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 5 MG
This compound is a selective, high-affinity, and orally bioavailable antagonist of the 5-HT2B receptor, exhibiting a pKi of 9.5. It demonstrates significantly higher selectivity (1000-fold) for this receptor compared to numerous other receptor and ion channel binding sites.
- High affinity for the target receptor.
- Orally bioavailable.
- Shows high selectivity, reducing off-target effects.
- Effective in inhibiting serotonin-induced intracellular calcium increases.
- Proven antagonist activity in cellular assays.
Accela Chembio Inc 2-(methylsulfonyl)ethylamine Hydrochloride | 5g | 104458-24-4 | MFCD03840162 | 97+% | Shelf Life: 900 Days | Moisture Sensitive
2-(methylsulfonyl)ethylamine Hydrochloride | 5g | 104458-24-4 | MFCD03840162 | 97+% | Shelf Life: 900 Days | Moisture Sensitive
Medchemexpress LLC Zm323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 25 MG
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. This anilinoquinazoline potently inhibits VEGFR2 (KDR) tyrosine kinase activity, showing excellent selectivity over other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation and VEGFR2 tyrosine phosphorylation.
- Potent and selective VEGFR2 inhibitor (IC50 < 2 nM)
- Inhibits VEGFR2 (KDR) tyrosine kinase activity
- Excellent selectivity over other receptor tyrosine kinases
- Inhibits VEGF-A-induced endothelial cell proliferation (IC50 = 8 nM)
- Inhibits VEGFR2 tyrosine phosphorylation
- Blocks activation of VEGFR-2, while sparing VEGFR-1, EGFR, PDGFR, and HGF receptor
- For research use only
Medchemexpress LLC 1-(4-methoxybenzyl)-5-trifluoromethoxyisatin | 1160247-92-6 | 99.9% | 25 MG
VU 0238429 is a research-grade positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5). In vitro it shows an EC50 of 1.16 μM and >30-fold selectivity versus M1 and M3, with no potentiation of M2 or M4. Supplied as a high-purity solid or as DMSO solutions, it is intended for laboratory research use.
- Positive allosteric modulator of mAChR5.
- In vitro potency EC50 1.16 μM.
- Greater than 30-fold selectivity versus M1 and M3.
- High purity (≈99.9%).
- Available as solid or 10 mM solution in DMSO.
- Recommended storage: powder -20°C; in solvent -80°C for long-term.
Medchemexpress LLC IACS-9571 hydrochloride | 2319611-93-1 | 98.3% | 679.22 | C32H43ClN4O8S | 50 MG
IACS-9571 hydrochloride is the hydrochloride salt form of a potent, selective inhibitor of the epigenetic readers TRIM24 and BRPF1. It is supplied as a solid for research use and offers improved aqueous solubility and stability versus the free base.
- Potent, selective inhibitor of TRIM24 and BRPF1 (IC50 8 nM; Kd 31 nM and 14 nM).
- High purity suitable for research (98.3%).
- Molecular weight 679.22; formula C32H43ClN4O8S.
- Solid, light brown to brown appearance; sealed storage recommended.
- Supplied with product data sheet and SDS for handling and storage.
eMolecules 1390654-84-8 | 2-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | AstaTech | MFCD00179635 | 273.012 | C7H15Br2N | 95.000 | Br.CN1CCCCC1CBr | 1g | 449792075
2-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | AstaTech | 1390654-84-8 | MFCD00179635 | 273.012 | C7H15Br2N | 95.000 | Br.CN1CCCCC1CBr | 1g | 449792075
eMolecules 3283-05-4 | AstaTech | NNNN-TETRAKIS(4-NITROPHENYL)-14-PHENYLENEDIAMINE | 1g | 448281454 | T72300 | 98 | MFCD23135517 | 592.524 | C30H20N6O8
Medchem Express | Alarelin (Acetate) | 10mg | 446268350 | HY-17405 | 79561-22-1 | MFCD30207842 | 1287.444 | C60H86N16O16
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