Hydrochlorides
Medchemexpress LLC CGP 54626 hydrochloride | 149184-21-4 | 99.8% | 444.76 g/mol | C18H29Cl3NO3P | 1 MG
CGP 54626 hydrochloride is a selective GABAB receptor antagonist for research use. It is supplied as a white to off-white solid with high purity and defined molecular properties, and is commonly used in receptor-binding and functional assays to study GABAB-mediated signaling.
- Selective GABAB receptor antagonist (IC50 ≈ 4 nM).
- High purity (≈99.8%).
- White to off-white solid appearance.
- Recommended storage: protected from light at -20°C; in solution -80°C for long term.
- Suitable for in vitro binding and functional assays.
- For research use only; not for human or veterinary use.
Apexbio Technology LLC Duloxetine HCl 136434-34-9 100mg
Duloxetine hydrochloride (CAS 136434-34-9) is a small molecule compound classified as a selective inhibitor of serotonin and norepinephrine reuptake By blocking the reabsorption of these neurotransmitters at the synaptic cleft duloxetine modulates serotonergic and noradrenergic signaling within the central nervous system This pharmacological action has rendered it a valuable tool in research models investigating neurochemical pathways involved in mood regulation pain perception and stress response Duloxetine HCl is commonly utilized in studies of depression anxiety and chronic pain to elucidate monoaminergic mechanisms and to evaluate therapeutic strategies targeting neurotransmitter reuptake
eMolecules 2-Pyridylacetic acid, HCl | 16179-97-8 | 5G | Purity: 95%
Combi-Blocks | 2-Pyridylacetic acid, HCl | 5G | 16179-97-8 | MFCD00012812
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Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 5 MG
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. It is intended for research use only and not for patient administration.
- Potent and selective P2X7 receptor antagonist
- High purity of 99.99%
- Appearance as a solid, white to off-white
- For research use only
Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 50 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes.
- Positive and highly selective mGlu5R allosteric modulator
- EC50 of 33 nM for mGlu5R
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Appearance: solid, white to off-white
- Solubility in DMSO: ≥ 50 mg/mL (163.76 mM)
Medchemexpress LLC Duloxetine metabolite Para-Naphthol Duloxetine | 949095-98-1 | 297.41 | 250 MG
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).
- Synonym: Para-naphthol duloxetine
- CAS number: 949095-98-1
- Molecular weight: 297.41
- Molecular formula: C18H19NOS
- Appearance: Solid
- Color: White to off-white
- Storage for powder: -20°C for 3 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 25 MG
EG01377 dihydrochloride is a potent, bioavailable, and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It exhibits antiangiogenic, antimigratory, and antitumor effects by inhibiting vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Inhibits VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Reduces HUVEC cell migration and delays VEGF-induced wound closure.
- Reduces network area, length, branching points, and VEGF-induced angiogenesis.
- Combines with VEGFA to reduce A375P (malignant melanoma) spheroid outgrowth.
- Blocks TGFβ production by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs).
- Exhibits a half-life of 4.29 h in mice, supporting once-daily dosing.
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 50 MG
RS-127445 is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites, making it suitable for research applications.
- High affinity for the 5-HT2B receptor (pKi = 9.5)
- 1000-fold selectivity for 5-HT2B receptor
- Orally bioavailable
- Appearance: solid, white to off-white
- Purity: 99.95%
- Store at 4°C, sealed, away from moisture; In solvent: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC SB-224289 hydrochloride | 180084-26-8 | 99.0% | 557.08 g/mol | C32H33ClN4O3 | 5 MG
A selective 5-HT1B receptor antagonist used in pharmacological research to study serotonin receptor function and behavioral effects. The hydrochloride salt is supplied as a white to off-white solid with high purity and documented solubility and storage conditions for in vitro and in vivo applications.
- Selective 5-HT1B receptor antagonist with reported anxiolytic effects.
- High affinity for 5-HT1B receptors (pKi ≈ 8).
- More than 80-fold selectivity over related receptors, improving assay specificity.
- Suitable for in vitro and in vivo studies, with recommended formulation guidance.
- High purity (99.0%), minimizing confounding impurities.
- Soluble in DMSO and formulated for several in vivo vehicles.
- Stable when stored under recommended conditions for long-term use.
Medchemexpress LLC BRL 52537 hydrochloride | 112282-24-3 | MFCD00672679 | 98.1% | 391.76 g/mol | C18H25Cl3N2O | 100 MG
BRL 52537 hydrochloride is a selective kappa-opioid receptor agonist research compound used to study opioid receptor pharmacology and neuroprotection. It reduces ischemia-evoked nitric oxide production and has demonstrated neuroprotective and antinociceptive effects in preclinical models, making it useful for both in vitro and in vivo neuroscience research.
- Selective kappa-opioid receptor agonist with high affinity.
- Reduces ischemia-evoked nitric oxide production in models.
- Demonstrated neuroprotective and antinociceptive effects.
- Suitable for in vitro and in vivo pharmacology studies.
- High reported purity for research applications.
![Medchemexpress LLC N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride | 1779796-27-8 | ≥98.0% | 421.91 g/mol | C22H28ClNO5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213907.png-250.jpg)
Medchemexpress LLC N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride | 1779796-27-8 | ≥98.0% | 421.91 g/mol | C22H28ClNO5 | 10 MG
LY2365109 hydrochloride is a selective small-molecule inhibitor of the glycine transporter 1 (GlyT1). It blocks glycine uptake in hGlyT1-expressing cells with an IC50 of 15.8 nM and is supplied as the hydrochloride salt for research use in neurochemical and pharmacological studies.
- Selective GlyT1 inhibition (IC50 15.8 nM)
- Hydrochloride salt, solid form
- High purity ≥98% (HPLC)
- Molecular weight 421.91 g/mol
- CAS 1779796-27-8
- Suitable for neurochemical and pharmacological research applications
Medchemexpress LLC K-604 dihydrochloride | 217094-32-1 | 99.4% | 575.64 g·mol⁻1 | C23H32Cl2N6OS3 | 1 ML
K-604 dihydrochloride is a potent, selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor used in biochemical and cellular research to study cholesterol esterification and related pathways. It is supplied as a 10 mM solution in DMSO or as a solid for preparation of assay stocks and controls.
- Potent, selective ACAT-1 inhibition with low micromolar IC50.
- Suitable for biochemical and cellular assays.
- Available as a 10 mM solution in DMSO and in solid pack sizes.
- High purity for research applications.
- Includes CAS, molecular formula, and molecular weight for identification.