Hydrochlorides
Sigma Aldrich Fine Chemicals Biosciences o-Phenylenediamine dihydrochloride tablet, 4 mg substrate per tablet | 615-28-1 | MFCD00012966 | 50TAB
o-Phenylenediamine dihydrochloride tablet, 4 mg substrate per tablet | Mol Wt: 181.06 | 615-28-1 | MFCD00012966 | 50TAB
Med Vet International Terbinafine Tablets (Lamisil), 250mg, 100ct
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Terbinafine is a generic version of Lamisil. It is an antifungal medication used to fight infections caused by fungus.
Medchemexpress LLC 5,7-dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride | 1123491-15-5 | MFCD02262123 | 99.1% | 339.22 g/mol | C16H16Cl2N2O2 | 5 MG
DMPQ dihydrochloride is the dihydrochloride salt of 5,7-dimethoxy-3-(4-pyridinyl)quinoline. It is a small-molecule inhibitor that selectively targets human platelet-derived growth factor receptor β (PDGFRβ) with reported biochemical potency, and is supplied as a light yellow to yellow solid for research use in biochemical and cell-based assays.
- Potent PDGFRβ inhibition with reported IC50 of 80 nM.
- High reported purity suitable for biochemical assays.
- Solid form, convenient for weighing and formulation.
- Available in multiple small pack sizes for research applications.
Medchemexpress LLC Azd-7762 hydrochloride | 1246094-78-9 | 99.58% | 398.88 | 25 MG
AZD-7762 hydrochloride is a potent ATP-competitive checkpoint kinase (Chk) inhibitor with an IC50 of 5 nM for Chk1. It inhibits Chk1 and Chk2, abrogates DNA damage-induced S and G2 checkpoints, enhances the efficacy of NSC 613327 and SKF 104864A, and modulates downstream checkpoint pathway proteins. It potentiates antitumor activity and induces lymphoma cell death in combination with CX-5461.
- Potent ATP-competitive checkpoint kinase (Chk) inhibitor.
- IC50 of 5 nM for Chk1.
- Equally potent inhibitor of Chk1 and Chk2 in vitro.
- Abrogates DNA damage-induced S and G2 checkpoints.
- Enhances the efficacy of NSC 613327 and SKF 104864A.
- Modulates downstream checkpoint pathway proteins.
- Binds to the ATP-binding site of Chk1.
- Potentiates antitumor activity in xenograft studies.
- Induces lymphoma cell death in combination with CX-5461.
Medchemexpress LLC Tp0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 50 MG
TP0427736 hydrochloride is the hydrochloride salt of a potent ALK5 (TGF-β type I receptor) kinase inhibitor for in vitro and preclinical research. It inhibits ALK5 with low-nanomolar potency and reduces Smad2/3 phosphorylation in cellular assays.
- Potent ALK5 inhibitor (ALK5 IC50 2.72 nM).
- Selective over ALK3 (ALK3 IC50 836 nM).
- Reduces Smad2/3 phosphorylation in A549 cells induced by TGF-β1 (8.68 nM).
- Molecular weight 334.85.
- Chemical formula C14H11ClN4S2.
- Purity 99.22%.
- Solid supplied as a 50 mg vial for laboratory research.
Medchemexpress LLC Zm323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 25 MG
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. This anilinoquinazoline potently inhibits VEGFR2 (KDR) tyrosine kinase activity, showing excellent selectivity over other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation and VEGFR2 tyrosine phosphorylation.
- Potent and selective VEGFR2 inhibitor (IC50 < 2 nM)
- Inhibits VEGFR2 (KDR) tyrosine kinase activity
- Excellent selectivity over other receptor tyrosine kinases
- Inhibits VEGF-A-induced endothelial cell proliferation (IC50 = 8 nM)
- Inhibits VEGFR2 tyrosine phosphorylation
- Blocks activation of VEGFR-2, while sparing VEGFR-1, EGFR, PDGFR, and HGF receptor
- For research use only
Medchemexpress LLC Erlotinib hydrochloride | 183319-69-9 | 99.9% | 10 MG
Erlotinib hydrochloride is the hydrochloride salt of erlotinib, an EGFR tyrosine kinase inhibitor used in research to study oncology, signal transduction, and inhibitor profiling. Supplied as a high-purity solid suitable for in vitro assays and formulation development.
- High purity suitable for biochemical and cell-based assays.
- Molecular weight 429.90 g/mol; formula C22H24ClN3O4.
- Soluble in DMSO (~3.33 mg/mL); in vivo formulation guidance provided by manufacturer.
- Available in small-mass packages for assay development, including 10 mg size.
- Acts as an EGFR tyrosine kinase inhibitor (IC50 ≈ 2 nM) for target validation studies.
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MM 1 ML
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. It does not induce intracellular calcium mobilization. Studies show it dose-dependently decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI), also blocking Phencyclidine (PCP)-induced deficits.
- GHSR-1a antagonist (IC50 of 32±3 nM)
- No intracellular calcium mobilization
- Dissociation constant (Kb) of 19±6 nM
- Decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI)
- Blocks PCP-induced PPI deficits
- Relevant for neurological disease and endocrinology research
- Store at 4°C (sealed, away from moisture) or in solvent at -80°C (6 months) / -20°C (1 month)
Medchemexpress LLC Naloxone (hydrochloride) | 357-08-4 | 100.0% | 363.84 | 500 MG
Naloxone hydrochloride is an antagonist of the Opioid receptor. It alleviates opioid-overdose-induced respiratory depression and may cause pulmonary edema and cardiac arrhythmias. It is for research use only and not sold to patients.
- Functions as an antagonist of the Opioid receptor.
- Helps to counteract respiratory depression caused by opioid overdose.
- Intended for research purposes.
Medchemexpress LLC 3-Pyridylacetic acid hydrochloride | 6419-36-9 | 173.60 | 10 G
3-Pyridineacetic acid hydrochloride is a high homolog of nicotinic acid and a decomposition product of nicotine (and other tobacco alkaloids). It can be used to synthesize anti-inflammatory agents or as a precursor for herbicides.
- High homolog of nicotinic acid
- Decomposition product of nicotine
- Precursor for herbicides
- Can be used to synthesize anti-inflammatory agents
- White to off-white solid appearance