Hydrochlorides
Medchemexpress LLC SB-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g/mol | C18H23ClIN3O3S | 25 MG
SB-258585 hydrochloride is a research-grade small molecule that binds with high affinity to the 5-HT6 (serotonin 6) receptor and is commonly used in receptor labeling and pharmacological studies.
- High affinity for the 5-HT6 receptor.
- Useful for labeling recombinant and native 5-HT6 receptors.
- High reported purity (about 99.7%).
- Provided as the hydrochloride salt for improved stability.
- Available in small research pack sizes, suitable for laboratory assays.
Apexbio Technology LLC VU 0361737 1161205-04-4 10mg
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease
Medchemexpress LLC LY2389575 hydrochloride | 885104-09-6 | MFCD09745778 | 99.9% | 438.58 g/mol | C15H16BrCl3N4 | 10 MG
LY2389575 hydrochloride is the hydrochloride salt of a selective, noncompetitive negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3), provided as a high-purity research reagent for preclinical studies, including investigation of amyloid beta-related mechanisms and Alzheimer's disease models.
- Selective, noncompetitive mGlu3 negative allosteric modulator.
- High purity (99.9%).
- Molecular formula C15H16BrCl3N4 and molecular weight 438.58 g/mol.
- Available in small research quantities, including 10 mg packaging.
- Stable as powder at -20°C (3 years) or 4°C (2 years); limited stability in solvent.
- For research use only; not for human or clinical use.
Medchemexpress LLC Duloxetine metabolite Para-Naphthol Duloxetine | 949095-98-1 | >98% | 297.41 | 10 MG
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).
- Solid appearance
- White to off-white color
- Ships at room temperature in continental US
- Powder stable for 3 years at -20°C
- In solvent stable for 6 months at -80°C, 1 month at -20°C
- Targeted as a drug metabolite
- Pathway is metabolic enzyme/protease
Medchemexpress LLC Urapidil hydrochloride | 64887-14-5 | 99.86% | 25 MG
Urapidil hydrochloride is an orally active and blood-brain barrier permeable α1-adrenoceptor antagonist and 5-HT1A receptor agonist. It has a pIC50 of 6.13 against α1-adrenoceptor and 4.38 against α2-adrenoceptor, exhibiting an antihypertensive effect.
- Orally active and blood-brain barrier permeable
- Acts as an α1-adrenoceptor antagonist and 5-HT1A receptor agonist
- Exhibits antihypertensive effect
- Research grade material with 99.86% purity
- Supplied as a white to off-white solid
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 1 ML
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
Medchemexpress LLC Procaine hydrochloride | 51-05-8 | 97.9% | 25 G
Procaine hydrochloride is a DNA-demethylating agent with multiple targets, characterized by a slow onset and short duration of action. It exhibits growth-inhibitory effects in human cancer cells by inducing mitotic arrest. Additionally, it functions as an excitant of limbic system cells and modifies synaptic transmission in certain amygdala output pathways. It can competitively inhibit the 5-HT3 receptor-mediated inward current in whole-cell patch clamp recordings with a KD of 1.7 microM.
- Inhibits 5-HT3 receptor-mediated inward current (KD of 1.7 microM).
- Reduces 5-methylcytosine DNA content by 40% and demethylates hypermethylated CpG islands.
- Exhibits growth-inhibitory effects in cancer cells by causing mitotic arrest.
- Excites limbic system cells and alters synaptic transmission in amygdala output pathways.
Medchemexpress LLC Benzenesulfonamide, 4-(aminomethyl)-, hydrochloride (1:1) | 138-37-4 | 99.97% | 1 ML
Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. It is active against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, by inhibiting nucleotide synthesis.
- Effective sulfonamide-type antimicrobial agent
- Used for burn wounds
- Active against Gram-positive and Gram-negative organisms
- Inhibits nucleotide synthesis
- For research use only
Medchemexpress LLC Lobeline hydrochloride | 134-63-4 | 99.97% | 250 MG
Lobeline hydrochloride is a brain-penetrant nicotinic receptor agonist that increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles and altering presynaptic DA storage. It is effective in smoking cessation.
- Acts as a brain-penetrant nicotinic receptor agonist
- Increases dopamine release by inhibiting dopamine uptake
- Alters presynaptic dopamine storage
- Effective in smoking cessation
- Appears as a white to off-white solid
- Purity is 99.97%
Medchemexpress LLC Eniporide hydrochlor 25mg | 211813-86-4 | 25MG
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na /H exchange inhibitor
