Hydrochlorides
Apexbio Technology LLC RS 127445 199864-87-4 10mM (in 1mL DMSO)
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity
Apexbio Technology LLC RS 127445 199864-87-4 10mg
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity
Apexbio Technology LLC RS 127445 199864-87-4 5mg
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity
Apexbio Technology LLC RS 127445 HCl 199864-87-4 5mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Apexbio Technology LLC RS 127445 HCl 199864-87-4 50mg
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes