Unclassified Organic Compounds
Biotium BAPTA, tetracesium salt
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium. Biotium offers several BAPTA chelators with calcium dissociation constants covering the biologically significant range from 10-7 to 10-2 M. Properties: Kd (no Mg2 ): 0.59 uM, Kd (1 mM Mg2 ): 0.70 uM; White solid soluble in water; Store at 4°C; C23H24Cs4N2O10; MW: 1004; [480436-84-8]
Biotium BAPTA, tetrapotassium salt
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium. Biotium offers several BAPTA chelators with calcium dissociation constants covering the biologically significant range from 10-7 to 10-2 M. Features: Kd (no Mg2 ): 0.59 uM, Kd (1 mM Mg2 ): 0.70 uM; White solid soluble in water; Store at 4°C; C23H24K4N2O10; MW: 656.85; [73630-08-7]
Enzo Life Sciences Phorbol 12-myristate 13-acetate, (1mg), CAS Number: 16561-29-8
PKC activator. PKC activator (10-100 ng/ml). Most commonly used phorbol ester. Causes an extremely wide range of effects in cells and tissues. Very potent mouse skin tumor promoter. Inhibits apoptosis induced by Fas, but induces apoptosis in HL-60 promyelocytic leukemia cells. Formula: C36H56O8. MW: 616.8. CAS Number: 16561-29-8. Purity: ≥99% (HPLC, TLC). Appearance: Colorless amorphous film or foam. Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers. Use/Stability: Dissolve in an organic solvent prior to dilution into aqueous buffers. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous buffer. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Long Term Storage: -20°C
AdipoGen L-Glutathione oxidized
Chemical. CAS 27025-41-8. Formula C20H32N6O12S2. MW 612.63. Glutathione can occur in reduced GSH, oxidized GSSG, or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. Glutathione, Oxidized GSSG is the oxidized version of the naturally occurring and very important antioxidant glutathione GSH. In vivo GSSG is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, therefore beeing an important bioindicator of cellular health. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.
AdipoGen L-Glutathione oxidized
Chemical. CAS 27025-41-8. Formula C20H32N6O12S2. MW 612.63. Glutathione can occur in reduced GSH, oxidized GSSG, or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. Glutathione, Oxidized GSSG is the oxidized version of the naturally occurring and very important antioxidant glutathione GSH. In vivo GSSG is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, therefore beeing an important bioindicator of cellular health. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.
Medchemexpress LLC Maleimido-mono-amide-DOTA | 1006711-90-5 | MFCD32708535 | 99.6% | 526.54 | C22H34N6O9 | 100 MG
Maleimide-DOTA is a non-cleavable antibody-drug conjugate (ADC) linker that combines a maleimide reactive group for thiol conjugation with a DOTA chelator for metal coordination and radiolabeling. It is supplied as a powder for research use and shows high solubility in common solvents and buffered formulations.
- Non-cleavable ADC linker suitable for antibody-drug conjugation
- Maleimide group enables thiol-specific conjugation
- DOTA chelator supports metal chelation and radiolabeling
- High solubility in DMSO and water; ultrasonic may be required
- Compatible with common in vivo vehicle systems at lower concentrations
- Store powder sealed at -20°C; in solution store at -80°C up to 6 months
AdipoGen L-Glutathione oxidized
Chemical. CAS 27025-41-8. Formula C20H32N6O12S2. MW 612.63. Glutathione can occur in reduced GSH, oxidized GSSG, or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. Glutathione, Oxidized GSSG is the oxidized version of the naturally occurring and very important antioxidant glutathione GSH. In vivo GSSG is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, therefore beeing an important bioindicator of cellular health. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.
Bioworld Focus™ DTT, 2M, 3483-12-3, 5 vials
For those who prefer DTT as a reducing agent, we offer ultra-pure proteomic grade DTT for protein reduction. FOCUS™ DTT is supplied as 5 vials containing dry powder to maintain the activity of the reducing agent. Add 1ml aliquot of water to give a 2M concentration, which is then added to your buffer solution to maintain protein reduction potential. Synonym: 1,4-Dithio-DL-threitol. Molecular Weight : 154.25, Molecular Formula : C4H10O2S2, Purity : >98%, Solubility : Freely soluble in water, ethanol, acetone, ether, chloroform, and ethyl acetate. Appearance Form : Solid, Appearance Color : White to Off-White, Melting Point : 41 - 44°C, Boiling Point : 125°C, Density : 1.04 g/mL at 20°C.
Mitegen Polyethyleneglycol 4000, 50% w/v, 100 mL, Single Stock Solution for Crystallization Optimization
This Polyethyleneglycol 4000 (PEG 4000) is supplied as a high-quality 50% w/v single stock solution in a convenient 100 mL bottle, specifically designed for optimizing protein crystallization conditions. As a widely utilized precipitant in crystallization screens, including various JBScreen formulations, PEG 4000 offers a versatile tool for fine-tuning experimental parameters. It allows researchers to move beyond initial screening results by precisely adjusting concentrations of precipitants, buffers, and salts. This precision is vital for improving crystal quality and reproducibility, essential for subsequent X-ray diffraction analysis and accurate structural determination. Its ready-to-use stock solution format streamlines experimental setup, enhancing efficiency in laboratories focused on structural biology and protein science. This reagent is indispensable for refining optimal conditions and achieving high-resolution structural data.
