Dimethyl Sulfoxide
Medchemexpress LLC 10 MM 1 ML IN DMSO READY 1MM
10 mM * 1 mL in DMSO ready for reconstitution, 1Mm, 2883540-92-7
Medchemexpress LLC Afatinib 10Mm 1Ml/Dmso Reconst | HY-10261-10MM 1ML RECONS
Afatinib 10Mm 1Ml/Dmso Reconst
Apexbio Technology LLC Bikinin(Synonyms: Bikinin, GSK3 Inhibitor VII, Glycogen Synthase Kinase-3 Inhibitor VII, GSK-3 Inhibitor VII), 10mM (in 1mL DMSO), CAS: 188011-69-0.
Bikinin (CAS 188011-69-0) is a small molecule inhibitor targeting glycogen synthase kinase 3 (GSK3)-like kinases particularly BIN2 thereby activating brassinosteroid (BR) signaling pathways downstream of the BRI1 receptor BR signaling regulates plant developmental processes including stem elongation vascular cell differentiation leaf expansion and stress responses Treatment with Bikinin can phenotypically rescue BR-insensitive mutants in Arabidopsis by restoring BR-dependent gene expression Additionally Bikinin usage promotes xylem cell differentiation in Nicotiana benthamiana leaf disk culture suggesting utility across different biological models
Apexbio Technology LLC Erlotinib Hydrochloride 183319-69-9 10mM (in 1mL DMSO)
Erlotinib hydrochloride (CAS 183319-69-9) is a small molecule inhibitor targeting the epidermal growth factor receptor (EGFR/HER-1) specifically blocking its tyrosine kinase activity By competitively inhibiting EGFR phosphorylation (IC50 2 nM) Erlotinib hydrochloride disrupts downstream signaling pathways involved in tumor cell proliferation apoptosis resistance migration and angiogenesis In vitro studies indicate this inhibitor induces G0/G1 cell cycle arrest and promotes apoptosis in cancer cell lines such as pancreatic (Bxpc-3 PANC-1) and hepatocellular carcinoma cells Erlotinib hydrochloride is widely studied in oncology research particularly in non-small cell lung cancer (NSCLC) and pancreatic cancer models
Apexbio Technology LLC Carbadox 6804-07-5 10mM (in 1mL DMSO)
Carbadox is an antibiotic compound employed in bacterial infection research primarily targeting pathogenic organisms associated with gastrointestinal infections in swine including swine dysentery Its antibacterial mechanism involves inhibition of bacterial DNA synthesis and disruption of nucleic acid metabolism thereby interfering with pathogen replication Carbadox is frequently utilized in microbiology studies investigating therapeutic interventions against enteric bacterial pathogens under controlled laboratory conditions In vitro studies report Carbadox demonstrating bacteriostatic activity with IC50 values typically ranging between 0 5 2 g/mL for common susceptible bacterial strains serving as a reference substance in microbial sensitivity assays
Apexbio Technology LLC MHY1485 326914-06-1 10mM (in 1mL DMSO)
MHY1485 (CAS 326914-06-1) is a potent activator of mammalian target of rapamycin (mTOR) a serine/threonine kinase critical for cellular growth metabolism and survival pathways By activating mTOR signaling MHY1485 inhibits autophagy initiation and disrupts the fusion step between autophagosomes and lysosomes resulting in accumulation of autophagic marker LC3-II and enlarged autophagic structures In cultured rat Ac2F hepatic cells MHY1485 suppresses basal and starvation-induced autophagic flux Additionally MHY1485 treatment promotes ovarian follicular development and increases explant growth in mouse ovarian culture models providing a useful tool in biomedical research of mTOR signaling and reproductive biology
Apexbio Technology LLC RO4929097(Synonyms: RO-4929097, RO 4929097, Gamma-Secretase Inhibitor RO4929097, RO4929097 γ-secretase inhibitor), 10mM (in 1mL DMSO), CAS: 847925-91-1.
RO4929097 (CAS 847925-91-1) is a potent selective small-molecule inhibitor of -secretase an essential protease in the Notch signaling pathway It inhibits -secretase with high specificity (IC50 4 nM EC50 5 nM) showing minimal inhibitory activity against closely related proteases and over 100-fold selectivity versus a broad spectrum of other proteases By preventing Notch receptor cleavage and subsequent signaling activation RO4929097 suppresses proliferation and tumorigenesis across various tumor models including melanoma breast colorectal pancreatic and lung cancers Clinical studies have assessed RO4929097 alone or combined with other anticancer agents for advanced solid tumors
Apexbio Technology LLC SCH772984 HCl 942183-80-4 (free base) 10mM (in 1mL DMSO)
SCH772984 HCl is a selective inhibitor targeting extracellular signal-regulated kinases 1 and 2 (ERK1/2) members of the mitogen-activated protein kinase (MAPK) pathway ERK activation is commonly implicated in cancer proliferation particularly in tumors harboring BRAF or RAS mutations SCH772984 HCl binds specifically to ERK1/2 blocking their kinase activity and downstream substrate phosphorylation In cell-based experiments it inhibits phosphorylation of ERK substrates such as p90 ribosomal S6 kinase (RSK) and decreases phosphorylation of ERK1/2 activation-loop residues In vivo SCH772984 HCl reduces tumor growth in xenograft mouse models bearing human melanoma cells with BRAF V600E mutation This compound is widely used in cancer research to study ERK-mediated signaling pathways and models exhibiting resistance to BRAF and MEK inhibitor therapies
Apexbio Technology LLC Tianeptine sodium(Synonyms: Stablon, Coaxil, Tatinol, Tianeurax, Salymbra, Tianeptine Sodium Salt), 10mM (in 1mL DMSO), CAS: 30123-17-2.
Tianeptine sodium (CAS 30123-17-2) is a small molecule known to selectively facilitate serotonin (5-HT) uptake in both in vitro and in vivo experimental models It exhibits minimal affinity toward various neurotransmitter receptors including serotonin and dopamine receptors (IC 10 M) and does not affect the uptake mechanisms of noradrenaline or dopamine Due to its distinct serotonergic modulation tianeptine sodium is extensively used in neuroscience research particularly in studies investigating the molecular basis and therapeutic potential of antidepressants
Apexbio Technology LLC VER 155008 1134156-31-2 10mM (in 1mL DMSO)
VER 155008 (CAS 1134156-31-2) is a small molecule inhibitor targeting members of the heat shock protein 70 (Hsp70) chaperone family It primarily inhibits Hsp70 by binding within its ATPase domain and suppressing its intrinsic ATPase activity thereby reducing chaperone-mediated cell survival functions VER 155008 demonstrates potent inhibition of Hsp70 (IC50 0 5 M) and exhibits moderate inhibitory action against related chaperones Hsc70 and glucose-regulated protein Grp78 In cancer cell models this compound diminishes cell proliferation and promotes apoptosis suggesting utility as a research tool in studying chaperone-dependent tumor cell survival pathways
Apexbio Technology LLC Penciclovir 39809-25-1 10mM (in 1mL DMSO)
Penciclovir is a selective inhibitor of herpes simplex virus 1 (HSV-1) DNA synthesis Structurally derived from guanine penciclovir undergoes phosphorylation within virus-infected cells forming penciclovir triphosphate the active antiviral metabolite Penciclovir triphosphate specifically targets viral DNA polymerase blocking HSV-1 DNA replication In vitro experiments using MRC-5 cells demonstrate inhibition of HSV-1 replication at an IC50 of 0 16 M without interfering with host cellular DNA synthesis This mechanism of action renders penciclovir suitable for antiviral research targeting HSV-1 replication as well as drug-resistance and mechanism-of-action studies involving HSV-2 and varicella-zoster virus (VZV)
Apexbio Technology LLC Pepstatin A 26305-03-3 10mM (in 1mL DMSO)
Pepstatin A is a pentapeptide functioning as an inhibitor targeting aspartic proteases including pepsin renin HIV protease and cathepsin D It inhibits human renin and HIV protease with IC50 values of approximately 15 M and 2 M respectively and shows inhibitory activity toward pepsin and cathepsin D at IC50 values below 5 M and 40 M Mechanistically Pepstatin A acts through binding to the catalytic site of aspartic proteases restricting proteolytic activity In biomedical research it is utilized to study viral protein processing osteoclast differentiation mediated by cathepsins and as a standard tool in enzyme inhibition assays examining aspartic protease function
Apexbio Technology LLC A939572 1032229-33-6 10mM (in 1mL DMSO)
A939572 (CAS 1032229-33-6) is an orally bioavailable small-molecule inhibitor targeting stearoyl-CoA desaturase 1 (SCD1) an enzyme that catalyzes the formation of monounsaturated fatty acids involved in lipid metabolism and body weight regulation A939572 selectively inhibits human and mouse SCD1 with IC50 values of 37 nM and 4 nM respectively exhibiting no inhibitory effect on associated cofactors cytochrome b5 or cytochrome b5 reductase By specifically interacting with SCD1 A939572 serves as a pharmacological tool in metabolic research particularly in studies focused on obesity and diabetes
Apexbio Technology LLC Simvastatin (Zocor) 79902-63-9 10mM (in 1mL DMSO)
Simvastatin (CAS 79902-63-9) marketed as Zocor is a synthetic lactone derived from fermented Aspergillus terreus metabolites Following oral administration the inactive lactone is hydrolyzed into an active -hydroxy acid metabolite which specifically inhibits HMG-CoA reductase the rate-limiting enzyme in cholesterol biosynthesis Simvastatin demonstrates antiproliferative effects in hepatocellular carcinoma cells (HepG2 Huh7) inducing apoptosis cell cycle arrest at G0/G1 reducing expression of cyclins (D1 E) and cyclin-dependent kinases (CDK1 2 4) while elevating CDK inhibitors p19 and p27 It is therefore utilized extensively for research in cancer biology cardiovascular pathology and lipid metabolism disorders