Dimethyl Sulfoxide
Apexbio Technology LLC Vidarabine 5536-17-4 10mM (in 1mL DMSO)
Vidarabine is an antiviral nucleoside analog widely studied for inhibiting replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV) Structurally vidarabine is an adenine arabinoside analog that interferes with viral DNA synthesis via competitive inhibition of viral DNA polymerase resulting in chain termination In vitro studies demonstrate antiviral activity against HSV type 1 and type 2 with IC50 values typically ranging approximately from 0 1 to 1 0 M depending on experimental conditions and viral strains Vidarabine is commonly used in biomedical laboratories for investigating viral replication mechanisms screening for antiviral candidates and elucidating nucleoside analog resistance patterns
Apexbio Technology LLC Apatinib 10mM (in 1mL DMSO)
B2303 is a synthetic small molecule designed for biomedical research acting primarily as an inhibitor targeting specific intracellular signaling pathways involved in cell proliferation and survival It modulates intracellular signaling cascades implicated in pathological conditions such as inflammation cancer progression and aberrant cell growth B2303 serves as a molecular probe suitable for investigating intracellular processes and as a tool for dissecting signal transduction mechanisms enabling researchers to explore therapeutic targets for various diseases
Apexbio Technology LLC Tetracaine HCl 136-47-0 10mM (in 1mL DMSO)
Tetracaine hydrochloride (CAS 136-47-0) is a small molecule local anesthetic commonly used in biomedical research It acts through allosteric modulation of ion channel function specifically inhibiting calcium channels and effectively suppressing voltage-dependent calcium release from the sarcoplasmic reticulum Due to its ability to regulate calcium channel activity tetracaine HCl serves as an important investigative tool in studies exploring calcium signaling pathways muscle physiology and neuronal excitability
Apexbio Technology LLC A-674563 552325-73-2 10mM (in 1mL DMSO)
A-674563 (CAS 552325-73-2) is a potent inhibitor of the serine/threonine kinase Akt1 (protein kinase B) with an IC50 of 14 nM It also demonstrates inhibitory activity against PKA and CDK2 with IC50 values of 16 nM and 46 nM respectively Akt regulates diverse cellular processes including proliferation apoptosis metabolism transcription and migration In cellular assays A-674563 suppresses proliferation in MiaPaCa-2 cells (EC50 0 4 M) reduces phosphorylation of GSK3 and MDM2 and induces G2-phase cell-cycle arrest and apoptosis in STS cells In mouse xenograft studies this inhibitor delays tumor growth and enhances paclitaxel efficacy illustrating its utility in oncology research
Apexbio Technology LLC Ticagrelor 274693-27-5 10mM (in 1mL DMSO)
Ticagrelor (CAS 274693-27-5) is an orally active reversible antagonist targeting the platelet P2Y12 receptor By competitively binding to P2Y12 ticagrelor inhibits ADP-mediated platelet aggregation resulting in dose-dependent suppression of platelet activation and thrombosis in vitro Unlike other P2Y12 inhibitors requiring metabolic activation ticagrelor acts without metabolic transformation though it is primarily metabolized by CYP3A4 and CYP2C19 enzymes This compound is frequently employed in biomedical research exploring platelet function thrombosis mechanisms and drug-drug interactions involving cytochrome P450 enzymes
Apexbio Technology LLC Gliclazide 21187-98-4 10mM (in 1mL DMSO)
Gliclazide (CAS 21187-98-4) is an oral hypoglycemic agent classified structurally as a sulfonylurea derivative It exerts its biological effects primarily by targeting pancreatic beta-cell sulfonylurea receptors (SUR1) stimulating insulin secretion through the closure of ATP-dependent potassium channels This channel inhibition induces cellular depolarization facilitating calcium influx and subsequent insulin exocytosis In a research context gliclazide is utilized extensively as a pharmacological tool to study pancreatic beta-cell function insulin secretion dynamics and diabetic pathophysiology
Apexbio Technology LLC Tretinoin (Aberela) 302-79-4 10mM (in 1mL DMSO)
Tretinoin (Aberela) is a pharmacologically active derivative of vitamin A (retinoic acid) widely utilized in biomedical research primarily for its therapeutic effects against acne vulgaris and keratosis follicularis At the cellular level tretinoin increases intracellular reduced glutathione levels and enhances catalase enzyme activity thus helping ameliorate oxidative stress caused by hydrogen peroxide in renal mesangial cell models It modulates inflammatory responses by suppressing expression of TNF- 1 and osteopontin proteins in renal tissue of aged rat models and regulates immunity in murine models by inhibition of lymphocyte proliferation and IL-17 secretion coupled with enhanced IL-10 production Additionally topical application in acne treatment research investigates its anti-inflammatory properties in combination formulations
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitable for HPLC, >=99.7% | 67-68-5 | MFCD00002089 | 4X2L
Dimethyl sulfoxide suitable for HPLC, >=99.7% | Purity: >=99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4X2L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5 | MFCD00002089 | 5vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 5vl
Apexbio Technology LLC ABT-737 852808-04-9 10mM (in 1mL DMSO)
ABT-737 (CAS 852808-04-9) is a small molecule inhibitor targeting the BCL-2 protein family exhibiting high binding affinity toward the anti-apoptotic proteins BCL-2 BCL-X L and BCL-w ABT-737 disrupts BCL-2/BAX protein interactions leading to apoptosis primarily via the BAK-mediated intrinsic pathway independent of BIM In preclinical studies ABT-737 demonstrated single-agent antitumor activity in lymphoma multiple myeloma and small-cell lung cancer models Additionally research indicates activity against acute myeloid leukemia (AML) cells progenitor cells and leukemia stem cells while sparing normal hematopoietic populations highlighting its potential for therapeutic research in hematologic malignancies
Apexbio Technology LLC Lafutidine 118288-08-7 10mM (in 1mL DMSO)
Lafutidine (CAS 118288-08-7) is a histamine H2 receptor antagonist that functions by inhibiting histamine-induced gastric acid secretion Through selective blockade of H2 receptors on gastric parietal cells it reduces basal and stimulated levels of gastric acid production Lafutidine is utilized in biomedical research exploring gastric physiology receptor signaling pathways and gastrointestinal pharmacology particularly in contexts related to acid-related disorders
Apexbio Technology LLC Olaparib (AZD2281, Ku-0059436) 763113-22-0 10mM (in 1mL DMSO)
Olaparib (AZD2281 Ku-0059436 CAS 763113-22-0) is a selective inhibitor of poly(ADP-ribose) polymerase-1 and -2 (PARP-1/2) By targeting PARP enzymes involved in DNA repair Olaparib specifically inhibits the proliferation of BRCA-deficient tumor cell lines and enhances radiosensitivity in experimental tumor models In xenograft mouse models of non-small cell lung carcinoma (NSCLC) Olaparib has been shown to elevate radiation sensitivity and improve tumor perfusion The compound is widely utilized in studies focused on DNA damage responses tumor radiosensitization and targeted therapy strategies for BRCA-associated cancers
Apexbio Technology LLC BMN 673 1207456-01-6 10mM (in 1mL DMSO)
BMN 673 (CAS 1207456-01-6) is a small-molecule inhibitor selectively targeting poly(ADP-ribose) polymerase isoforms PARP1 and PARP2 enzymes crucial for DNA repair pathways BMN 673 demonstrates potent inhibition with reported Ki values of 1 2 nM and 0 9 nM against PARP1 and PARP2 respectively and minimal off-target interactions across diverse receptors ion channels and enzymes In preclinical studies BMN 673 displayed substantial antitumor activity in tumor cells and xenograft models exhibiting homologous recombination repair deficits with enhanced efficacy noted in combination with DNA-damaging agents Currently BMN 673 is under clinical investigation in advanced solid tumors and hematological malignancies
Apexbio Technology LLC Aloperine 56293-29-9 10mM (in 1mL DMSO)
Aloperine is a naturally derived alkaloid known for its biological properties including anti-inflammatory antiviral antibacterial and antitumor activities Mechanistic studies suggest that aloperine exerts anti-inflammatory effects through inhibition of inflammatory mediators and inflammatory signaling pathways such as nuclear factor-kappa B (NF- B) and mitogen-activated protein kinase (MAPK) pathways In vitro assays demonstrate antiviral potential related to inhibition of specific viral replication stages Additionally its antitumor properties have been identified in multiple cancer cell lines where aloperine can induce apoptosis inhibit proliferation and migration and modulate cell cycle progression Aloperine typically exhibits IC50 values ranging from low micromolar to sub-micromolar concentrations depending on cell lines and experimental settings It serves as a research tool compound in immunological oncological and infectious disease studies
Apexbio Technology LLC Bindarit 130641-38-2 10mM (in 1mL DMSO)
Bindarit (CAS 130641-38-2) also known as AF-2838 is a synthetic small-molecule inhibitor targeting the CC chemokines MCP-1 (CCL2) MCP-2 (CCL8) and MCP-3 (CCL7) By suppressing the transcription and production of MCP proteins Bindarit reduces monocyte chemoattraction and inflammation In vitro data indicate that Bindarit inhibits LPS-induced MCP-1 synthesis in monocytes with an IC50 around 172 M and selectively decreases MCP expression without impacting unrelated cytokines such as IL-6 or IL-8 Animal studies demonstrate its potential to reduce inflammatory cell infiltration vascular smooth muscle cell proliferation and neointimal hyperplasia in rodent injury models highlighting its value for inflammation and cardiovascular disease research