Dimethyl Sulfoxide
Sigma Aldrich Phenyl vinyl sulfoxide
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PROTIDE PHARMACEUTICAL STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
VWR INTERNATIONAL LLC Dimethyl sulfoxide | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Dimethyl sulfoxide | Purity: ≥99.9% | Ultra Pure Grade | MW: 78.14 g/mol | 67-68-5 | MFCD00002089 | 5 x 10mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide Hybri-Max, 99.7, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, ≥99.7%, Molecular Weight 78.13, Hybri-Max™, sterile-filtered, BioReagent, Synonym: DMSO
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 5x10mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, BioPerformance Certified, suitable for hybridoma, Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets USP and EP testing requirements.
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 5X10ML
NC3592570 DIMETHYL SULFOXIDE 5X10ML
Apexbio Technology LLC Santacruzamate A (CAY10683) 1477949-42-0 10mM (in 1mL DMSO)
Santacruzamate A (CAY10683 CAS 1477949-42-0) is a selective histone deacetylase (HDAC) inhibitor originally identified in the marine cyanobacterium cf Symploca sp Its mechanism of action involves targeting HDAC enzymes particularly demonstrating high selectivity towards HDAC2 (IC 0 112 nM) when compared with HDAC6 (IC 433 nM) and minimal potency against HDAC4 (IC 1 M) In cellular assays Santacruzamate A reduces growth of tumor cell lines such as HCT-116 colon cancer cells (GI 28 M) and HuT-78 cutaneous T-cell lymphoma cells (GI 1 3 M) It is valuable in epigenetics and oncology research for selectively modulating HDAC2 activity
Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 10mM (in 1mL DMSO)
Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Apexbio Technology LLC TG003 300801-52-9 10mM (in 1mL DMSO)
TG003 (CAS 300801-52-9) is a selective inhibitor targeting the Cdc2-like kinase (Clk) family and casein kinase 1 (CK1) Specifically it demonstrates notable potency against mClk1 mClk2 and mClk4 with IC50 values of approximately 20 nM 200 nM and 15 nM respectively TG003 competitively binds with ATP at Clk1 modulating Clk-mediated phosphorylation of serine/arginine-rich (SR) proteins involved in alternative mRNA splicing Studies using HeLa cellular extracts and animal models have shown that TG003 alters splice site selection and pre-mRNA processing suggesting potential utility for investigating RNA splicing regulatory mechanisms
Apexbio Technology LLC CB-5083 1542705-92-9 10mM (in 1mL DMSO)
CB-5083 (CAS 1542705-92-9) is an orally bioavailable small-molecule inhibitor targeting the AAA ATPase p97 (also termed valosin-containing protein VCP) P97 functions in diverse cellular processes related to protein homeostasis including membrane fusion intracellular trafficking and degradation pathways CB-5083 selectively inhibits the second ATPase domain of p97 (IC50 15 4 nM) promoting cytoplasmic protein degradation and triggering apoptosis in cultured cancer cell lines such as A549 and HCT116 In vivo orally administered CB-5083 demonstrates significant reduction of tumor growth in xenograft models The compound is being investigated clinically for treatment of solid tumors and multiple myeloma