Dimethyl Sulfoxide
PROTIDE PHARMACEUTICAL STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
STEMSOL 99.9% DMSO USP VIAL GLASS 50ML
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydro1L
Dimethyl Sulfoxide is an apolar protic solvent that is generally used as a reaction medium and reagent in organic reactions.
Cayman Chemical PerphenazIn SulfoxIde 10mg
A synthetic GHRH peptide induces growth hormone release similarly to GHRH in vitro and in vivo
Cayman Chemical QuetIapIn SulfoxIde 10mg
A lipase inhibitor inhibits 12 lipases including FAAH FASN and ABHD4 in mouse T cell hybridoma lysates at 2 UM inhibits depalmitoylation of H-Ras in HEK293 cells
Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis
Apexbio Technology LLC Forskolin 66575-29-9 10mM (in 1mL DMSO)
Forskolin (CAS 66575-29-9) is a diterpenoid isolated from the plant Coleus forskohlii known to directly activate adenylate cyclase type I thereby elevating cellular cyclic AMP (cAMP) concentrations It exhibits an IC50 of approximately 41 nM against adenylate cyclase By increasing intracellular cAMP forskolin modulates signaling pathways involved in inflammation and oxidative stress reducing macrophage activation and subsequent production of thromboxane B2 and superoxide Forskolin has been explored in various experimental models and clinical contexts including cardiovascular disorders diabetes mellitus and asthma research
Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
Apexbio Technology LLC AST-1306 897383-62-9 10mM (in 1mL DMSO)
AST-1306 (CAS 897383-62-9) is an inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptor tyrosine kinases In biochemical assays AST-1306 inhibits EGFR and HER2 kinase activity with IC50 values of 0 5 nM and 3 nM respectively It also demonstrates inhibitory activity against EGFR mutations such as T790M/L858R reducing receptor phosphorylation and downstream signaling in both cell-free and cellular systems In various animal tumor models including ErbB2-overexpressing and SK-OV-3 xenografts AST-1306 suppresses tumor growth and signaling pathways supporting its use in EGFR- and HER2-related oncology research
Apexbio Technology LLC ZM 447439 331771-20-1 10mM (in 1mL DMSO)
ZM 447439 (CAS 331771-20-1) is a selective inhibitor of Aurora kinases a subgroup within the serine/threonine kinase family involved in chromosome segregation during cell division It inhibits recombinant Aurora A and Aurora B kinases with IC50 values of approximately 110 nM and 130 nM respectively consequently reducing phosphorylation of histone H3 at serine 10 ZM 447439 demonstrates limited inhibitory activity towards other kinases with IC50 values above 10 M for CDK1/2/4 IKK1/2 PLK1 CHK1 cFLT2 KDR2 FAK and Zap-70 In biological research ZM 447439 is commonly employed to study mitotic regulation chromosomal alignment and apoptosis signaling pathways
Apexbio Technology LLC Lonafarnib 193275-84-2 10mM (in 1mL DMSO)
Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
Apexbio Technology LLC Nilotinib(AMN-107) 641571-10-0 10mM (in 1mL DMSO)
Nilotinib (AMN-107 CAS 641571-10-0) is an orally bioavailable selective inhibitor targeting the BCR-ABL tyrosine kinase Derived structurally from imatinib nilotinib inhibits both wild-type (WT p210) and mutant forms (E281K E292K F317L M351T F486S) of BCR-ABL reducing their autophosphorylation activity with IC50 values ranging from 20 to 42 nM It also exhibits substantial inhibitory activity against activated KIT mutants (e g V560del K642E) and various KIT double mutations and effectively suppresses PDGFR and PDGFR kinases Nilotinib is utilized extensively in research related to chronic myeloid leukemia and gastrointestinal stromal tumors involving kinase-driven pathologies
Apexbio Technology LLC INK 128 (MLN0128) 1224844-38-5 10mM (in 1mL DMSO)
INK 128 (MLN0128 CAS 1224844-38-5) is a selective inhibitor of the mammalian target of rapamycin (mTOR) a conserved serine/threonine kinase integral to the PI3K/AKT/mTOR signaling pathway This compound inhibits both mTOR complexes (mTORC1 and mTORC2) demonstrating an IC50 of approximately 1 nM In preclinical studies utilizing human pancreatic and HER2-positive breast cancer cell lines INK 128 significantly reduced cellular proliferation and viability via concentration- and time-dependent suppression of mTOR activity Moreover it exhibited notable tumor suppression in breast cancer xenograft models enhancing efficacy when combined with agents such as sorafenib sunitinib paclitaxel or lapatinib highlighting its potential value for oncology research and therapeutic development
Apexbio Technology LLC Flutamide 13311-84-7 10mM (in 1mL DMSO)
Flutamide is a synthetic nonsteroidal antiandrogen agent commonly employed in biomedical research and clinical oncology Its pharmacological activity is mediated through competitive antagonism at the androgen receptor (AR) whereby its active metabolite interacts specifically with AR exhibiting a receptor binding affinity at a K sub i /sub value around 55 nM By interfering with androgen signaling pathways flutamide inhibits AR-mediated transcriptional activity resulting in reduced cellular proliferation particularly in androgen-dependent tissues In research contexts this compound is frequently utilized to investigate AR-mediated cell biology androgen-dependent tumor development and as a pharmacological tool in model systems studying prostate cancer biology and therapeutic resistance mechanisms