Dimethyl Sulfoxide
Apexbio Technology LLC Baicalein 491-67-8 10mM (in 1mL DMSO)
Baicalein is a natural flavonoid compound extracted from the medicinal herb Scutellaria baicalensis known to function as an inhibitor of lipoxygenase enzymes It selectively inhibits the 12-lipoxygenase (12-LOX) mediated metabolic pathway involved in arachidonic acid metabolism subsequently modulating inflammatory responses and cell proliferation signaling Baicalein demonstrates bioactivity as reflected by reported IC50 values typically ranging from 0 6 M to 2 5 M against purified human platelet 12-LOX enzyme It is utilized in biomedical research primarily to study inflammation pathways tumor cell proliferation processes and mechanisms underlying apoptosis induction
Apexbio Technology LLC ANA 12 219766-25-3 10mM (in 1mL DMSO)
ANA 12 (CAS 219766-25-3) is a potent and selective antagonist of tropomyosin receptor kinase B (TrkB) the receptor for neurotrophins BDNF and NT-4/5 It binds non-competitively to extracellular sites on TrkB exhibiting IC50 values of 45 6 nM (high-affinity site) and 41 1 M (low-affinity site) ANA 12 inhibits BDNF-induced TrkB activation effectively blocking downstream signaling pathways including PLC- PI3K and MAPK In mouse models ANA 12 administration reduces endogenous brain TrkB activity and demonstrates antidepressant and anxiolytic properties supporting its use for researching psychiatric disorders and neuronal signaling
Apexbio Technology LLC MRT67307 HCl 2095432-39-4 10mM (in 1mL DMSO)
MRT67307 HCl (CAS 2095432-39-4) is a small-molecule inhibitor targeting several kinases including TBK1 IKK MARK1-4 NUAK1 ULK1/2 and salt-inducible kinases (SIK1-3) It inhibits TBK1 and IKK to block phosphorylation of IRF3 reducing interferon- synthesis without affecting NF- B activation Additionally MRT67307-mediated SIK inhibition promotes regulatory macrophage differentiation leading to elevated anti-inflammatory cytokines (e g IL-10 IL-1ra) and decreased pro-inflammatory cytokines (IL-6 IL-12 TNF) It is utilized to investigate innate immunity macrophage polarization autophagy and inflammation pathways
Apexbio Technology LLC Zebularine 3690-10-6 10mM (in 1mL DMSO)
Zebularine (CAS number 3690-10-6) is a chemically stable cytidine analog containing a 2-(1H)-pyrimidinone ring structure It acts primarily through inhibition of DNA methylation by forming covalent complexes with DNA methyltransferases Zebularine treatment leads to demethylation and reactivation of hypermethylation-mediated silenced genes exemplified by the p16 gene Additionally induced myogenic differentiation has been observed upon zebularine administration in 10T1/2 cells Zebularine displays minimal cytotoxicity in certain cell models such as T24 cells and retains stability in aqueous solutions across a broad pH range (up to pH 12) These properties make zebularine relevant for studies in epigenetic regulation and cellular differentiation
Apexbio Technology LLC Q-VD(OMe)-OPh 10mM (in 1mL DMSO)
Q-VD(OMe)-OPh is a pan-caspase inhibitor structurally identified as quinolyl-valyl-O-methylaspartyl-[2 6-difluorophenoxy]-methyl ketone As a broad-spectrum inhibitor Q-VD(OMe)-OPh reversibly targets multiple caspases involved in apoptotic signaling including initiator caspases (such as caspases 8 9 10 and 12) and executioner caspases (such as caspase 3) thereby blocking intrinsic extrinsic and endoplasmic reticulum-mediated apoptotic pathways In recombinant enzyme assays this inhibitor displays nanomolar-range IC values against caspases 1 3 8 and 9 Due to minimal cytotoxicity at tested concentrations Q-VD(OMe)-OPh serves as a tool compound in apoptosis-related biomedical research applied broadly for dissecting caspase-dependent apoptotic mechanisms and evaluating cytoprotective strategies