Dimethyl Sulfoxide
Apexbio Technology LLC Sorafenib(Synonyms: Nexavar, BAY 43-9006, BAY-43-9006, BAY439006, Sorafenib Tosylate, BAY-545-9085), 10mM (in 1mL DMSO), CAS: 284461-73-0.
Sorafenib (CAS 284461-73-0) is an orally bioavailable small molecule inhibitor targeting multiple kinases including Raf kinase as well as receptor tyrosine kinases such as VEGFR2 PDGFR FLT3 Ret and c-Kit By inhibiting Raf signaling pathways sorafenib suppresses tumor cell proliferation induces apoptosis and disrupts tumor angiogenesis In vitro studies demonstrate that sorafenib effectively inhibits Raf-mediated signaling cascades and blocks the proliferation of tumor cells Sorafenib serves as an important research tool in the study of cancer biology particularly in investigating antiangiogenic and antiproliferative mechanisms in various tumor models
Apexbio Technology LLC AM095 1345614-59-6 10mM (in 1mL DMSO)
AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
Apexbio Technology LLC Mocetinostat (MGCD0103, MG0103) 726169-73-9 10mM (in 1mL DMSO)
Mocetinostat (MGCD0103 MG0103 CAS 726169-73-9) is an isotype-selective inhibitor of human histone deacetylases (HDACs) It selectively targets class I HDAC enzymes (HDAC1 HDAC2 HDAC3) and class IV HDAC11 without affecting class II HDACs Mocetinostat inhibits these isoforms with IC50 values of 0 15 mol/L (HDAC1) 0 29 mol/L (HDAC2) 1 66 mol/L (HDAC3) and 0 59 mol/L (HDAC11) resulting in histone hyperacetylation cell cycle arrest and apoptosis in various cancer cell lines It serves as a research tool for studying epigenetic regulation and as a candidate compound for anticancer drug development
Apexbio Technology LLC A-674563 552325-73-2 10mM (in 1mL DMSO)
A-674563 (CAS 552325-73-2) is a potent inhibitor of the serine/threonine kinase Akt1 (protein kinase B) with an IC50 of 14 nM It also demonstrates inhibitory activity against PKA and CDK2 with IC50 values of 16 nM and 46 nM respectively Akt regulates diverse cellular processes including proliferation apoptosis metabolism transcription and migration In cellular assays A-674563 suppresses proliferation in MiaPaCa-2 cells (EC50 0 4 M) reduces phosphorylation of GSK3 and MDM2 and induces G2-phase cell-cycle arrest and apoptosis in STS cells In mouse xenograft studies this inhibitor delays tumor growth and enhances paclitaxel efficacy illustrating its utility in oncology research