Dimethyl Sulfoxide
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 10mM (in 1mL DMSO)
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation
Apexbio Technology LLC Ferrostatin-1 (Fer-1) 347174-05-4 10mM (in 1mL DMSO)
Ferrostatin-1 (Fer-1) is a selective inhibitor of ferroptosis a regulated form of iron-dependent oxidative cell death characterized by lipid peroxidation It functions primarily by reducing lipid reactive oxygen species (ROS) thus inhibiting membrane lipid peroxidation and preventing ferroptosis induction triggered by compounds such as erastin In experimental contexts Fer-1 is employed to investigate ferroptotic pathways in different disease models including cancer biology neurodegeneration and ischemic injury Ferrostatin-1 demonstrates an IC50 value of approximately 60 nM in inhibiting ferroptosis induced by erastin in cellular assays rendering it suitable for mechanistic studies and therapeutic research involving modulation of iron-dependent oxidative damage pathways