Tetrahydrofuran
Medchemexpress LLC Erk1/2 inhibitor 2 (ASTX-029) | 2095719-92-7 | >98.0% | 584.04 g/mol | C29H31ClFN5O5 | 25MG
ASTX029 is a dual-mechanism extracellular signal-regulated kinase (ERK) 1/2 inhibitor developed as a clinical candidate. It inhibits ERK catalytic activity and ERK phosphorylation, with reported ERK2 IC50 ≈ 2.7 nM, and has demonstrated antineoplastic activity in preclinical models and early clinical evaluation. Supplied as a crystalline solid for research use, typical vendor-reported purity is ≥98% (CAS 2095719-92-7).
- Potent dual-mechanism ERK inhibitor with low-nanomolar potency.
- Inhibits both catalytic activity and phosphorylation of ERK.
- Demonstrated antineoplastic activity in preclinical and early clinical studies.
- Supplied as a crystalline solid suitable for in vitro and in vivo formulation.
- Typical purity ≥98% by vendor testing.
- CAS number 2095719-92-7 and molecular weight ≈584.04 g/mol.
- For research use only; not for human therapeutic use.
Medchemexpress LLC 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethan-1-one | 1693766-04-9 | 99.5% | 323.39 g·mol⁻¹ | C20H21NO3 | 25 MG
GSK8573 is a small-molecule research reagent used as a structurally related inactive control for acetyl-lysine competitive bromodomain inhibitors. It exhibits measurable binding to BRD9 (Kd ≈ 1.04 μM) and is supplied with characterization data and storage recommendations for reliable use in biochemical and cell-based assays.
- High purity, supporting reproducible experimental results (reported ≈99.5%).
- Validated as an inactive control for bromodomain inhibitor studies.
- Measurable BRD9 binding, useful for target engagement comparisons.
- Available in multiple pack sizes to suit assay throughput needs.
- Detailed solubility and storage guidance for sample preparation and stability.
Medchemexpress LLC Naz2329 | 2809469-05-2 | 99.0% | 501.56 g·mol⁻¹ | C21H18F3NO4S3 | 50 MG
NAZ2329 is a small-molecule research inhibitor that allosterically and preferentially inhibits receptor-type protein tyrosine phosphatases PTPRZ and PTPRG. It is supplied as a solid for laboratory research and is characterized by high purity and established solubility in DMSO.
- Allosterically inhibits PTPRZ and PTPRG (reported IC50: PTPRZ 7.5 μM, PTPRG 4.8 μM).
- Cas number 2809469-05-2.
- Purity 99.02%.
- Molecular formula C21H18F3NO4S3.
- Molecular weight 501.56 g·mol⁻¹.
- Appearance solid, white to off-white.
- Soluble in DMSO (~100 mg/mL).
- Pack size 50 mg.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years).
Medchemexpress LLC Ralaniten triacetate | 1637573-04-6 | 98.8% | 521.00 g/mol | C27H33ClO8 | 10MG
Ralaniten triacetate is an orally active prodrug that targets the androgen receptor N-terminal domain (AR-NTD) and is provided for non-clinical research into AR-driven prostate cancer mechanisms. Manufacturer data include analytical and handling information to support experimental use.
- Prodrug of ralaniten that targets the androgen receptor N-terminal domain.
- Orally active in preclinical studies.
- High purity suitable for research applications.
- Molecular weight 521.00 g/mol; formula C27H33ClO8.
- Appearance: liquid, colorless to light yellow.
- Storage conditions provided for pure form and for solutions.
- For research use only; not for human or veterinary use.
![Medchemexpress LLC N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide | 368449-04-1 | 98.6% | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232288.png-250.jpg)
Medchemexpress LLC N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide | 368449-04-1 | 98.6% | 25MG
N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide | 368449-04-1 | 98.6% | 25MG
Medchemexpress LLC D-α-tocopherylquinone | 7559-04-8 | MFCD00135657 | 98.9% | 446.71 | C29H50O3 | 10 MG
- Oxidation product of α-tocopherol with quinone structure.
- Exhibits antioxidant and anticoagulant activity.
- Reduces oxidative damage from oxidized lipids.
- Interacts with glutathione-S-transferase (GST).
- Used in reactive oxygen species (ROS) and lipid peroxidation research.
- Molecular formula C29H50O3; MW 446.71 Da.
Medchemexpress LLC Cur61414 | 334998-36-6 | 99.0% | 550.69 | 50 MG
CUR61414 is a novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor with an IC50 of 100-200 nM. It is a small-molecule aminoproline class compound that selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Novel, potent, and cell-permeable Hedgehog signaling pathway inhibitor.
- Selectively binds to smoothened (Smo).
- Induces apoptosis in cancer cells without affecting neighboring non-tumor cells.
- Able to arrest proliferation of basal cells within BCC-like lesions and induce apoptosis, leading to complete regression of lesions.
- Causes regression of BCC-like lesions in mice exposed to UV light irradiation, with no overt toxicity observed in surrounding skin.
Medchemexpress LLC Kinase, Natto fermentation | 133876-92-3 | 27728 Da | 50 MG
Kinase, Natto fermentation is a potent fibrinolytic enzyme that can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. It can be used for the research of cardiovascular diseases.
- Breaks down blood clots
- Molecular weight: 27728 Da
- Relatively stable in neutral or alkaline environment (pH 7.0-12.0)
- Sensitive to high temperature, with better stability below 37°C
- Retains 95% activity after 5 freeze-thaw cycles
- Exhibits fibrinolytic activity and dissolves blood clots in vivo
Medchemexpress LLC (R)-Tetrahydrofuran-2-carboxylic acid | 87392-05-0 | 116.12 | 25 G
(R)-Tetrahydrofuran-2-carboxylic acid is a chiral building block used for Faropenem. Faropenem is a clinically effective non-natural β-lactam antibiotic.
- Serves as a chiral building block for the synthesis of Faropenem.
- The product has a purity of 99.93%.
- Its appearance is described as a liquid with a density of 1.209 g/cm³, ranging from colorless to light yellow.
- Intended for research use only.
Medchemexpress LLC Pelcitoclax (APG-1252) | 1619923-36-2 | 99.7% | 1281.85 g·mol⁻¹ | C57H66ClF4N6O11PS4 | 5 MG
Pelcitoclax is a small-molecule dual inhibitor of Bcl-2 and Bcl-xL used in oncology research. It induces apoptosis and has demonstrated antitumor activity in preclinical models, and is supplied with characterized molecular properties and high analytical purity for research applications.
- Dual Bcl-2 and Bcl-xL inhibition mechanism
- Promotes apoptosis in tumor cells
- Demonstrated antitumor activity in preclinical studies
- High analytical purity for consistent results
- Available as solid and ready-to-use DMSO solution formats
Medchemexpress LLC p-Ethynylphenylalanine hydrochloride | 188640-63-3 | 99.23% | 225.67 | 50 MG
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible, and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, selective, reversible, and competitive inhibitor of tryptophan hydroxylase (TPH).
- Click chemistry reagent.
- Contains an Alkyne group for CuAAc reactions.
- Selectively and reversibly inhibits the biosynthesis of serotonin.
- Decreases 5-HT and 5-HIAA levels in the rat midbrain (at 30 mg/kg; i.p.).
- Does not inhibit aromatic amino acid decarboxylase.
![Medchemexpress LLC Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy- | 41307-63-5 | 99.9% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231270.png-250.jpg)
Medchemexpress LLC Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy- | 41307-63-5 | 99.9% | 25 MG
Resorcinolnaphthalein is a small-molecule research reagent (C24H14O5) used as an ACE2 enhancer in biochemical assays. It is supplied as a high-purity solid suitable for in vitro research.
- Functions as an ACE2 enhancer with reported EC50 of 19.5 μM.
- High purity as measured by LCMS (99.9%).
- Provided as a light yellow to orange solid; available in solid quantities and as a 10 mM solution in DMSO.
- Molecular weight 382.4 g/mol; formula C24H14O5.
- Intended for research use only and not for human use.
Medchemexpress LLC Mpt0b392 | 1346169-92-3 | 99.6% | 404.44 g/mol | C19H20N2O6S | 10 MG
MPT0B392 is a research-grade microtubule-depolymerizing agent for preclinical studies of tubulin dynamics and cancer drug resistance. It is an orally active quinoline derivative that inhibits tubulin polymerization, activates c-Jun N-terminal kinase (JNK), induces mitotic arrest, and promotes apoptosis. Supplied as a solid or as a 10 mM solution in DMSO for in vitro and in vivo research use.
- Novel microtubule-depolymerizing mechanism supporting tubulin studies.
- Induces JNK activation and mitotic arrest for apoptosis research.
- Available as solid or 10 mM solution in DMSO for flexible dosing.
- High listed purity (99.63%) suitable for biochemical assays.
- Documented molecular weight and formula to aid experimental planning.
Medchemexpress LLC DS08210767 | 2376334-75-5 | 99.4% | 513.67 | C31H39N5O2 | 25MG
DS08210767 is a small-molecule antagonist of the parathyroid hormone receptor 1 (PTHR1) for research use. It is reported to be orally bioavailable and shows an in vitro IC50 of 90 nM against PTHR1. The compound is supplied as a light yellow to yellow solid with high reported purity and is intended for biochemical and cellular studies; follow manufacturer storage recommendations.
![eMolecules AstaTech / 25-BIS(BROMOMETHYL)TEREPHTHALONITRILE / 0.1g / 696742362 / D81099 / 95.000 / 64746-04-9 / [null] / 313.980 / C10H6Br2N2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465106.JPG-250.jpg)
eMolecules AstaTech / 25-BIS(BROMOMETHYL)TEREPHTHALONITRILE / 0.1g / 696742362 / D81099 / 95.000 / 64746-04-9 / [null] / 313.980 / C10H6Br2N2
AstaTech / 25-BIS(BROMOMETHYL)TEREPHTHALONITRILE / 0.1g / 696742362 / D81099 / 95.000 / 64746-04-9 / [null] / 313.980 / C10H6Br2N2