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Menthol (CAS 1490-04-6) is a widely used small molecule modulator of the TRPM8 ion channel which is implicated in cold sensation By activating TRPM8 menthol induces a cooling response in sensory neurons It also inhibits neuronal calcium channel currents contributing to its analgesic and anti-irritant properties In animal studies menthol has been shown to reduce aversive responses to oral nicotine administration in mice Due to these pharmacological actions menthol serves as a reference standard in biomedical research focused on pain perception sensory modulation and mechanisms of addiction
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Alantolactone a naturally occurring eudesmane-type sesquiterpene lactone (SL) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction
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